<i>Angiostrongylus cantonensis</i> (Nematoda: Metastrongylidae) in the Ryukyu Islands Tree Rat (<i>Diplothrix legata</i>)

Okano, Tsukasa; Haga, Akihiro; Mizuno, Eriko; Onuma, Manabu; Nakaya, Yumiko; Nakagawa, Takashi

doi:10.7589/2013-03-050

Cited by 14 publications

(10 citation statements)

References 5 publications

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“…The adventitia of infected and uninfected arteries was infiltrated primarily by plasma cells. Okano et al. (2014) reported A. cantonensis in Ryukyu Islands tree rats, Diplothrix legata , noted that pathological observations were similar to those reported by Mackerras and Sandars (1955) for A. mackerrasae and suggested that they might be lethal in this rat species.…”

Section: Impacts On Hosts – Pathology and Pathogenesissupporting

confidence: 68%

Species of Angiostrongylus (Nematoda: Metastrongyloidea) in wildlife: A review

Spratt

2015

International Journal for Parasitology: Parasites and Wildlife

119

179

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HighlightsTwenty-one species of Angiostrongylus are recognised from wildlife around the world.Details of hosts, life cycles, pathogenesis, geographical range are known for nine.Six species are spreading into new regions locally or globally.Two species, A. cantonensis and A. costaricensis, are zoonotic.A. mackerrasae, A. malaysiensis and A. siamensis are potentially zoonotic.Debilitating disease occurs in avian and mammalian wildlife and humans in Australia.

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Section: Impacts On Hosts – Pathology and Pathogenesissupporting

confidence: 68%

Species of Angiostrongylus (Nematoda: Metastrongyloidea) in wildlife: A review

Spratt

2015

International Journal for Parasitology: Parasites and Wildlife

119

179

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“…Non- Rattus rats such as the bandicoot rat ( Bandicota indica ) and the white-toothed rat ( Berylmys berdmorei ), are also definitive hosts of A. cantonensis (Pipitgool et al 1997; Deng et al 2012; Yong and Eamsobhana, 2013). The finding of adult A. cantonensis in the Ryukyu Islands tree rat ( Diplothrix legata ) (Okano et al 2014) also implicates this species as a definitive host, though this requires further investigation. Experimental infections in Mongolian gerbils ( Meriones unguiculatus ) confirmed they are highly susceptible to angiostrongyliasis yet behave as poor definitive hosts; worms developed to sexual maturity in gerbils though very few L 1 larvae were shed in their feces (Wei et al 2014).…”

Section: Life Cycle and Transmissionmentioning

confidence: 99%

“…Angiostrongylus cantonensis has also been detected in Japan, parts of Southern USA, the Caribbean Islands [though it was absent in rats from Barbados (Levett et al 2004)], Tenerife, Brazil, Papua New Guinea, French Polynesia, Fiji, the Philippines, Indonesia, Sri Lanka, India, South Africa and Egypt (Tables 1 and 2, Fig. 5) (Alicata, 1965 b ; Kliks and Palumbo, 1992; Uga et al 1996; Asato et al 2004; Batmanian and O'Neill, 2004; Lindo et al 2004; Abo-Madyan et al 2005; Owen, 2005; Waugh et al 2005; Caldeira et al 2007; Chikweto et al 2009; Dorta-Contreras et al 2009; Archer et al 2011; Constantino-Santos et al 2014; Oehler et al 2014; Okano et al 2014; Lammers et al 2015; Stockdale-Walden et al 2015).…”

Section: Epidemiology and Global Distributionmentioning

confidence: 99%

Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen

et al. 2016

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Angiostrongylus cantonensis is a metastrongyloid nematode found widely in the Asia-Pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis. Rattus rats are definitive hosts of A. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs. Humans are dead-end hosts that usually become infected upon ingestion of infected molluscs. A presumptive diagnosis is often made based on clinical features, a history of mollusc consumption, eosinophilic pleocytosis in cerebral spinal fluid, and advanced imaging such as computed tomography. Serological tests are available for angiostrongyliasis, though many tests are still under development. While there is no treatment consensus, therapy often includes a combination of anthelmintics and corticosteroids. Angiostrongyliasis is relatively rare, but is often associated with morbidity and sometimes mortality. Recent reports suggest the parasites' range is increasing, leading to fatalities in regions previously considered Angiostrongylus-free, and sometimes, delayed diagnosis in newly invaded regions. Increased awareness of angiostrongyliasis would facilitate rapid diagnosis and improved clinical outcomes. This paper summarizes knowledge on the parasites' life cycle, clinical aspects and epidemiology. The molecular biology of Angiostrongylus spp. is also discussed. Attention is paid to the significance of angiostrongyliasis in Australia, given the recent severe cases reported from the Sydney region.

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“…For example, ribosomal DNA sequences were used to assess metastrongylid nematode relationships (Carreno & Nadler, 2003) or to help survey larvae from mollusk intermediate hosts (Fontanilla & Wade, 2008; Qvarnstrom, Sullivan, Bishop, Hollingsworth, & da Silva, 2007; Qvarnstrom et al., 2010), and ~360‐bp region of the cytochrome c oxidase 1 ( CO 1) gene was used to assess relationships to other species of Angiostrongylus (Eamsobhana et al., 2010). To date, molecular systematic/phylogeographic studies on A. cantonensis have mainly used two mitochondrial (mtDNA) markers, CO 1 and cytochrome b ( CYTB ), where the focus has largely been descriptive in terms of reporting local patterns of haplotype variants (Aghazadeh et al., 2015; Dalton, Fenton, Cleveland, Elsmo, & Yabsley, 2017; Dusitsittipon, Criscione, Morand, Komalamisra, & Thaenkham, 2017; Dusitsittipon, Thaenkham, Watthanakulpanich, Adisakwattana, & Komalamisra, 2015; Eamsobhana, Song, et al., 2017; Eamsobhana, Yong, et al., 2017; Lv et al., 2012; Monte et al., 2012; Moreira et al., 2013; Nakaya et al., 2013; Okano et al., 2014; Rodpai et al., 2016; Simoes et al., 2011; Tokiwa et al., 2012, 2013; Vitta et al., 2016; Yong, Eamsobhana, Song, Prasartvit, & Lim, 2015; Yong, Song, Eamsobhana, Goh, & Lim, 2015; Yong, Song, Eamsobhana, & Lim, 2016). …”

Section: Introductionmentioning

confidence: 99%

Hurdles in the evolutionary epidemiology of Angiostrongylus cantonensis: Pseudogenes, incongruence between taxonomy and DNA sequence variants, and cryptic lineages

Dusitsittipon

Criscione

Morand

et al. 2018

Evolutionary Applications

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Angiostrongylus cantonensis, the rat lungworm, is a zoonotic pathogen that is one of the leading causes of eosinophilic meningitis worldwide. This parasite is regarded as an emerging pathogen with a global range expansion out of southeastern Asia post‐WWII. To date, molecular systematic/phylogeographic studies on A. cantonensis have mainly used two mitochondrial (mtDNA) markers, cytochrome c oxidase 1 (CO1) and cytochrome b (CYTB), where the focus has largely been descriptive in terms of reporting local patterns of haplotype variants. In order to look for more global evolutionary patterns, we herein provide a collective phylogenetic assessment using the six available whole mtDNA genome samples that have been tagged as A. cantonensis, A. malaysiensis, or A. mackerrasae along with all other GenBank CO1 and CYTB partial sequences that carry these species identifiers. The results reveal three important complications that researchers will need to be aware of, or will need to resolve, prior to conducting future molecular evolutionary studies on A. cantonensis. These three problems are (i) incongruence between taxonomic identifications and mtDNA variants (haplotypes or whole mtDNA genome samples), (ii) the presence of a CYTB mtDNA pseudogene, and (iii) the need to verify A. mackerrasae as a species along with other possible cryptic lineages, of which there is suggestive evidence (i.e., A. cantonensis could be a species complex). We provided a discussion of how these complications are hurdles to our understanding of the global epidemiology of angiostrongyliasis. We call for future studies to be more explicit in morphological traits used for identifications (e.g., provide measurements). Moreover, it will be necessary to repeat prior morphological and life‐history studies while simultaneously using sequence data in order to assess possible associations between critical epidemiological data (e.g., biogeography, virulence/pathology, host species use) and specific lineages.

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Angiostrongylus cantonensis (Nematoda: Metastrongylidae) in the Ryukyu Islands Tree Rat (Diplothrix legata)

Cited by 14 publications

References 5 publications

Species of Angiostrongylus (Nematoda: Metastrongyloidea) in wildlife: A review

Species of Angiostrongylus (Nematoda: Metastrongyloidea) in wildlife: A review

Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen

Hurdles in the evolutionary epidemiology of Angiostrongylus cantonensis: Pseudogenes, incongruence between taxonomy and DNA sequence variants, and cryptic lineages

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