anti‐Markovnikov Iodofluorination of Alkenes

Abstract

The fluorination of alkenes with electrophilic N−F type reagents usually occurs through a Markovnikov‐type addition, and the anti‐Markovnikov‐type addition may require the use of a transition metal catalyst or an expensive catalyst. Herein we describe a convenient anti‐Markovnikov iodofluorination of alkenes with Selectfluor/nBu4NI. A wide substrate scope and good functional group tolerance were observed. The process allows for the construction of various C−F bonds, especially tertiary C−F bonds. The remarkable features make this protocol attractive, including convenient operations, simple reaction conditions, and the installation of an iodine atom which provides possibilities for further transformations.