Ariadne merione ecdysone receptor (AmEcR) protein: An in silico approach for comparison of agonist and antagonist compounds

Sundaravadivelan, C.; Easwaran, Murugesh; Preethy, Mathew; Prabu, Sivaprasath

doi:10.1016/j.ejbas.2017.10.002

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…However, their potential to control mosquito larvae is largely unknown (Morou et al, 2013). These products act via binding to the ecdysone receptor causing precocious lethal molting (Tohidi-Esfahani et al, 2011;Sundaravadivelan et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Activity of a selective insecticide (methoxyfenozide) against two mosquito species (Culex pipiensandCuliseta longiareolata): toxicological, biometrical and biochemical study

2018

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Methoxyfenozide is an insect growth disruptor belonging to the class of nonsteroidal ecdysone agonists. In the present study, methoxyfenozide (23% emulsifiable concentrate) is evaluated against newly molted fourth‐instar larvae of Culex pipiens L. and Culiseta longiareolata Macquart (Diptera: Culicidae), aiming to investigate its possible effects on growth and development. Larvae are exposed for 24 h under standard laboratory conditions in accordance with World Health Organization recommendations. The product is found to exhibit insecticidal activity against the two tested mosquito species with a concentration–response relationship. Moreover, based on the lethal concentrations determined, methoxyfenozide is slightly more toxic against C. pipiens than C. longiareolata. Furthermore, fourth‐instar larva of the two mosquito species are treated using two lethal concentrations (LC50 and LC90) of methoxyfenozide, and then individual survivals (larvae, pupae and adults) from larval treatment are subjected to a biometrical and biochemical study. The compound is found to interfere with growth by reducing the larval and pupal development duration. Moreover, the body volume and the main biochemical contents (proteins, carbohydrates and lipids) from different stages are affected. The overall results suggest that the ecdysone agonist under investigation interferes with the development process and has potential for mosquito control.

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Section: Discussionmentioning

confidence: 99%

Activity of a selective insecticide (methoxyfenozide) against two mosquito species (Culex pipiensandCuliseta longiareolata): toxicological, biometrical and biochemical study

2018

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Molecular characterization and volatile binding properties of pheromone binding proteins and general odorant binding proteins in Conogethes pinicolalis (Lepidoptera: Crambidae)

Jing

Zhang

Prabu

et al. 2020

International Journal of Biological Macromolecules

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Using Open Source Tools for Analysis of the Mutation Rate of African Cassava Mosaic Virus

et al. 2018

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Popular tools used in studies in life sciences are often costly. This often pauses challenges to researchers in spite of the fact that research continues to be a key to the successful systematic development of new knowledge and a fundamental aspect to the usefulness of all higher education. Particularly, higher education also aims to advance, create and disseminate knowledge through research. Such critical studies like mutation studies therefore require affordable and fast results yielding software. In such research, open source software tools become handy in place of expensive proprietary tools. In order to provide alternative software tools for research, we decided to use a case study of the mutation of the African Cassava Mosaic Virus (ACMV) done by researchers in Zambia. The study of ACMV mutation is hampered by fragmented and non-user-friendly tools, which are currently available. A number of the tools used also depend on network connection, especially the Internet, to access and analyze data. To help alleviate this problem this research proposes the use of open source libraries in biopython to generate cost efficient and user-friendly solutions. Additionally, we propose the use of an open standard using XML as a standard protocol to share data between applications or stages in genomic data analysis of the ACMV. In our strife to provide open source solutions we analysed various tools and noted that biopython is quite popular. During our study of biopython our initial results show that it’s possible to use free tools to analyze data in the life sciences and consequently reduce the time and cost required to analyze ACMV. Based on this case study we propose the adoption of such open source libraries in order to make research much more affordable for scientists in the life sciences for researches that operate within a constrained budget.

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Ariadne merione ecdysone receptor (AmEcR) protein: An in silico approach for comparison of agonist and antagonist compounds

Cited by 3 publications

References 27 publications

Activity of a selective insecticide (methoxyfenozide) against two mosquito species (Culex pipiensandCuliseta longiareolata): toxicological, biometrical and biochemical study

Activity of a selective insecticide (methoxyfenozide) against two mosquito species (Culex pipiensandCuliseta longiareolata): toxicological, biometrical and biochemical study

Molecular characterization and volatile binding properties of pheromone binding proteins and general odorant binding proteins in Conogethes pinicolalis (Lepidoptera: Crambidae)

Using Open Source Tools for Analysis of the Mutation Rate of African Cassava Mosaic Virus

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