<i>Aspergillus nidulans</i> HOG pathway is activated only by two‐component signalling pathway in response to osmotic stress

Furukawa, Kentaro; Hoshi, Yukiko; Maeda, Tatsuya; Nakajima, Tasuku; Abe, Keietsu

doi:10.1111/j.1365-2958.2005.04605.x

Cited by 185 publications

(219 citation statements)

References 58 publications

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“…Although the role of Ssk1 in a two-component signaling system and a high-osmolarity glycerol pathway has been well characterized in yeast, only one functional analysis has been conducted on the Ssk1 homologue in filamentous fungi. In that report, an Aspergillus nidulans ssk1 (sskA) mutant showed an osmosensitive phenotype and a deficiency of HOG1 MAPK phosphorylation (Furukawa et al, 2005). The data from the study using C. heterostrophus suggested that the Ssk1-type response regulator plays roles in high-osmolarity adaptation and in the mode of action of the fungicides.…”

Section: Rr Involved In the Osmotic Signaling System And The Mode Of mentioning

confidence: 95%

Two-Component Signaling System in Filamentous Fungi and the Mode of Action of Dicarboximide and Phenylpyrrole Fungicides

Tanaka¹,

Izumitsu²

2010

Fungicides

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Section: Rr Involved In the Osmotic Signaling System And The Mode Of mentioning

confidence: 95%

Two-Component Signaling System in Filamentous Fungi and the Mode of Action of Dicarboximide and Phenylpyrrole Fungicides

Tanaka¹,

Izumitsu²

2010

Fungicides

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“…For instance, S. cerevisiae relays osmotic stress signals to the HOG1 MAPK pathway through the SLN1-YPD1-SSK1 phosphorelay system (Maeda et al, 1994;Posas et al, 1996), while the TcsA/TcsB/NikA sensor kinases transmit stress signals to the HogA/SakA MAPK cascade through YpdA and SskA in Aspergillus nidulans (Furukawa et al, 2005;Virginia et al, 2000). In Candida albicans, a similar system consists of the histidine kinases CaSln1, Chk1 and Nik1/Cos1 (Alex et al, 1998;Calera & Calderone, 1999a; Nagahashi et al, 1998), the phosphorelay protein CaYpd1 and two RRs (CaSsk1, CaSkn7) (Calera & Calderone, 1999b;Calera et al, 2000) (Figure 2B).…”

Section: Stress Responses Cause Widespread Changes In Transcriptionmentioning

confidence: 99%

Oxidative stress response pathways: Fission yeast as archetype

Papadakis¹,

Workman²

2015

Critical Reviews in Microbiology

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Schizosaccharomyces pombe is a popular model eukaryotic organism to study diverse aspects of mammalian biology, including responses to cellular stress triggered by redox imbalances within its compartments. The review considers the current knowledge on the signaling pathways that govern the transcriptional response of fission yeast cells to elevated levels of hydrogen peroxide. Particular attention is paid to the mechanisms that yeast cells employ to promote cell survival in conditions of intermediate and acute oxidative stress. The role of the Sty1/Spc1/Phh1 mitogen-activated protein kinase in regulating gene expression at multiple levels is discussed in detail.

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“…Furthermore, the Sho1 branch in many fungi does not seem to be connected to Pbs2 homologues nor involved in responding to osmotic stress. [23][24][25] …”

Section: Resultsmentioning

confidence: 99%

In vivo measurement of signaling cascade dynamics

McClean¹,

Hersen²,

Ramanathan³

2009

Cell Cycle

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Genetic and biochemical studies yield information about the component proteins and interactions involved in a cellular signaling pathway. However this parts inventory often does not immediately reveal the in vivo signal processing capabilities and function of the pathway. Signaling pathways are complex systems with dynamic behavior and a systems level approach is needed to understand the physiological roles they play within the cell. We recently used such an approach to measure the signal processing behavior of the budding yeast HOG MAP kinase pathway in response to precisely varied temporal stimuli controlled with a microfluidic device. Despite being a well-studied pathway with well-known components the signaling dynamics and biochemical parameters of this pathway were not known. Our approach allowed us to characterize the pathway's in vivo signal processing and put bounds on all of the in vivo reaction rates. The experimental and theoretical techniques used in our study are general and can be applied to understanding other signaling pathways in a range of biological systems.

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Aspergillus nidulans HOG pathway is activated only by two‐component signalling pathway in response to osmotic stress

Cited by 185 publications

References 58 publications

Two-Component Signaling System in Filamentous Fungi and the Mode of Action of Dicarboximide and Phenylpyrrole Fungicides

Two-Component Signaling System in Filamentous Fungi and the Mode of Action of Dicarboximide and Phenylpyrrole Fungicides

Oxidative stress response pathways: Fission yeast as archetype

In vivo measurement of signaling cascade dynamics

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