<i>Bacillus licheniformis</i> Isolated from Traditional Korean Food Resources Enhances the Longevity of <i>Caenorhabditis elegans</i> through Serotonin Signaling

Park, Mi Ri; Oh, Sangnam; Son, Seung Bae; Park, Dong-Jun; Oh, Sejong; Kim, Sae Hun; Jeong, Do Youn; Oh, Nam Su; Lee, Youngbok; Song, Min Ho; Kim, Young-Hoon

doi:10.1021/acs.jafc.5b03730

Cited by 42 publications

(20 citation statements)

References 35 publications

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“…Certain probiotic bacteria have been shown to increase the lifespan of C. elegans (Grompone et al, 2012; Park et al, 2015) but our isolate had the opposite effect on T. castaneum . Furthermore the fertility of the beetle was also reduced following treatment with the E. mundtii isolate.…”

Section: Discussionmentioning

confidence: 59%

Probiotic Enterococcus mundtii Isolate Protects the Model Insect Tribolium castaneum against Bacillus thuringiensis

2017

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Enterococcus mundtii strains isolated from the larval feces of the Mediterranean flour moth Ephestia kuehniella show antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria. The in vitro probiotic characterization of one isolate revealed a high auto-aggregation score, a hydrophilic cell surface, tolerance for low pH, no hemolytic activity, and susceptibility to all tested antibiotics. We used the red flour beetle Tribolium castaneum, an established model organism, for the in vivo characterization of one probiotic E. mundtii isolate from E. kuehniella larvae. Tribolium castaneum larvae were fed orally with the probiotic isolate or the corresponding supernatant and then infected with either the entomopathogen Bacillus thuringiensis or Pseudomonas entomophila. Larvae exposed to the isolate or the supernatant showed increased survival following infection with B. thuringiensis but not P. entomophila. Heat treatment or treatment with proteinase K reduced the probiotic effect of the supernatant. However, the increased resistance attracts a fitness penalty manifested as a shorter lifespan and reduced fertility. T. castaneum has, pending on further research, the potential as an alternative model for the pre-screening of probiotics.

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Section: Discussionmentioning

confidence: 59%

Probiotic Enterococcus mundtii Isolate Protects the Model Insect Tribolium castaneum against Bacillus thuringiensis

2017

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“…According to our hypothesis, Park et al (2014) observed that newly isolated strains of L. plantarum , which were more efficient in colonizing the nematode gut with respect to LGG, were able to extend the worm’s lifespan. However, this aspect is still controversial, since other authors reported a negative correlation between colonization capacity and lifespan extension (Brokate-Llanos et al, 2014; Park et al, 2015), or suggested that gut colonization does not directly influence the host defense response (Yun et al, 2014). It must be pointed out that in the case of E. coli as food source, the reduction of colonization capacity could lower bacterial pathogenicity resulting in an increased worm’s longevity (Brokate-Llanos et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…It must be pointed out that in the case of E. coli as food source, the reduction of colonization capacity could lower bacterial pathogenicity resulting in an increased worm’s longevity (Brokate-Llanos et al, 2014). Moreover, it has been observed that the effects of bacterial feeding on worm longevity are often strain-specific (Park et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in the recent past a growing body of literature demonstrated that the nematode can be successfully used to screen the probiotic features of several bacterial strains. Park et al (2015) analyzed potentially probiotic Bacillus licheniformis strains isolated from traditional Korean food sources in terms of protection against Staphylococcus aureus infection (Yun et al, 2014), as well as of ability to enhance longevity of nematodes. Recently, Lactobacillus gasseri SBT2055, which had been previously demonstrated to exert beneficial effects in mice and humans, in terms of improvement of the intestinal environment and prevention of infection by influenza A virus (Nakayama et al, 2014), showed a positive impact on longevity and/or aging in the nematode through the modulation of skn-1 gene (Nakagawa et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Combination of Metabolomic and Proteomic Analysis Revealed Different Features among Lactobacillus delbrueckii Subspecies bulgaricus and lactis Strains While In Vivo Testing in the Model Organism Caenorhabditis elegans Highlighted Probiotic Properties

et al. 2017

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Lactobacillus delbrueckii represents a technologically relevant member of lactic acid bacteria, since the two subspecies bulgaricus and lactis are widely associated with fermented dairy products. In the present work, we report the characterization of two commercial strains belonging to L. delbrueckii subspecies bulgaricus, lactis and a novel strain previously isolated from a traditional fermented fresh cheese. A phenomic approach was performed by combining metabolomic and proteomic analysis of the three strains, which were subsequently supplemented as food source to the model organism Caenorhabditis elegans, with the final aim to evaluate their possible probiotic effects. Restriction analysis of 16S ribosomal DNA revealed that the novel foodborne strain belonged to L. delbrueckii subspecies lactis. Proteomic and metabolomic approaches showed differences in folate, aminoacid and sugar metabolic pathways among the three strains. Moreover, evaluation of C. elegans lifespan, larval development, brood size, and bacterial colonization capacity demonstrated that L. delbrueckii subsp. bulgaricus diet exerted beneficial effects on nematodes. On the other hand, both L. delbrueckii subsp. lactis strains affected lifespan and larval development. We have characterized three strains belonging to L. delbrueckii subspecies bulgaricus and lactis highlighting their divergent origin. In particular, the two closely related isolates L. delbrueckii subspecies lactis display different galactose metabolic capabilities. Moreover, the L. delbrueckii subspecies bulgaricus strain demonstrated potential probiotic features. Combination of omic platforms coupled with in vivo screening in the simple model organism C. elegans is a powerful tool to characterize industrially relevant bacterial isolates.

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“…The experiments with mutant strains, ser-1, and ser-7 (serotonin receptor gene), tph-1 (tryptophan hydroxylase), mod-1 (serotoningated chloride channel), bas-1 (serotonin-and dopamine-synthetic aromatic amino acid decarboxylase), revealed that B. licheniformis has an impact on serotonin signaling system. The lifespan extension was mediated by the serotonin signaling [58].…”

Section: Anti-aging Property Of Probioticsmentioning

confidence: 99%

A Review on Anti-Aging Properties of Probiotics

2018

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Aging is the inevitable biological event associated with several physiological, behavioral, and lifestyle events, but people do not wish to become old. The market for anti-aging products is growing gradually, and customers are aware of active principles in the cosmetics. The probiotics are known for several health benefits; especially probiotics regulate the gut health and immune system. Recent studies emphasized the role of probiotics, and probiotic-containing fermented products in cosmetics, and aging. The whole mechanism of aging has not been elucidated yet, but modern aging theories are in two different categories such as programmed theory and damage theory. The aging mechanisms can be discussed in organismal, and cellular level. To some extent, organismal and premature aging is controlled by genetic makeup. Though genetic, and environmental factors impact healthy aging, diet and gut microbiota also play a significant role in senescence. Aging is greatly associated with a diversity of gut microbiota that is often related to the changes in the gastrointestinal tract, and dietary patterns, together with an associated decline in cognitive and immune function, eventually contributing to infirmity. Lactic acid bacteria are reported for the ability to extend the lifespan and/or healthspan. The current manuscript discussed the aging mechanisms, an association of microbiome and aging, and compiled the reported anti-aging properties of probiotics.

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Bacillus licheniformis Isolated from Traditional Korean Food Resources Enhances the Longevity of Caenorhabditis elegans through Serotonin Signaling

Cited by 42 publications

References 35 publications

Probiotic Enterococcus mundtii Isolate Protects the Model Insect Tribolium castaneum against Bacillus thuringiensis

Probiotic Enterococcus mundtii Isolate Protects the Model Insect Tribolium castaneum against Bacillus thuringiensis

Combination of Metabolomic and Proteomic Analysis Revealed Different Features among Lactobacillus delbrueckii Subspecies bulgaricus and lactis Strains While In Vivo Testing in the Model Organism Caenorhabditis elegans Highlighted Probiotic Properties

A Review on Anti-Aging Properties of Probiotics

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