2021
DOI: 10.1021/acsomega.1c00790
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Bacillus subtilis in PVA Microparticles for Treating Open Wounds

Abstract: Open wound dressings should provide a moist environment, protect the wound from bacterial contamination, and shield it from further damage. These requirements, however, are hard to accomplish since such wounds are colonized by pathogenic bacteria, including resistant species such as methicillin-resistant Staphylococcus aureus (MRSA). A new approach for treating open wounds that is based on sticky and dissolvable polyvinyl alcohol (PVA) microparticles containing live Bacillus subtilis (B. subtilis) is described… Show more

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Cited by 9 publications
(5 citation statements)
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“…The differences between the tested compositions were also discernible in terms of actual appearance (Figure 4B). The observed toxicity of polymer solutions at high concentrations is attributed to the low availability of water to cells due to the high viscosity of the polymers in DMEM solution [19]. Notably, the concentrations assessed here are an order of magnitude higher than the relevant clinical concentration.…”
Section: Cell Toxicitymentioning
confidence: 79%
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“…The differences between the tested compositions were also discernible in terms of actual appearance (Figure 4B). The observed toxicity of polymer solutions at high concentrations is attributed to the low availability of water to cells due to the high viscosity of the polymers in DMEM solution [19]. Notably, the concentrations assessed here are an order of magnitude higher than the relevant clinical concentration.…”
Section: Cell Toxicitymentioning
confidence: 79%
“…Since dissolvable MNs can painlessly bypass the skin's epidermis, dissolve at the treated area, and release drugs directly to the inner skin layers [13][14][15], they are often used as common drug delivery systems [16]. Polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) have been chosen as the matrix thanks to their water soluble and hygroscopic nature, making them ideal for a wide range of skin care and cosmetic products in which it is crucial to maintain moisture [17][18][19]. Both PVA and PVP are considered ideal for fabricating fibers, films, and MNs due to their semi-crystalline structure and excellent physical properties [20][21][22].…”
Section: Introductionmentioning
confidence: 99%
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“…It is worth noting that bacteria of the genus Bacillus have never been used in topical preparation for wound healing in animals in general [9,27]. Only one study reported the use of Bacillus subtilis to treat open wounds in vivo in mice as a model [28]. Several examples of formulation for human applications were reported where species of Bacillus with other species helped to treat skin microbiota dysbiosis and wound healing.…”
Section: Discussionmentioning
confidence: 99%
“…Спреї з Bacillus spp. продемонстрували високу ефективність в експерименті та клініці за рахунок зниження інфікування пато-генною мікрофлорою (включно з мультирезистентними штамами) та позитивного впливу на процеси епітелізації [22,[30][31][32].…”
Section: ванкоміцинunclassified