<i>Bacopa monnieri</i>Phytochemicals Mediated Synthesis of Platinum Nanoparticles and Its Neurorescue Effect on 1-Methyl 4-Phenyl 1,2,3,6 Tetrahydropyridine-Induced Experimental Parkinsonism in Zebrafish

Nellore, Jayshree; Pauline, Cynthia; Amarnath, Kanchana

doi:10.1155/2013/972391

Cited by 71 publications

(34 citation statements)

References 40 publications

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“…For instance, the herbal extracts, generally used for green synthesis of nanoparticles, contain phenols, sugars and acids which act as reducing as well as stabilizing agents. Such phytochemicals in combination with cis-platin synergise apoptosis in breast cancer and cervical cancer [52, 72, 84]. A combination of platinum nanoparticles with ion irradiation has been found to enhance the efficiency of cancer therapy [85].…”

Section: Reviewmentioning

confidence: 99%

Green Synthesis, Characterization and Uses of Palladium/Platinum Nanoparticles

2016

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Biogenic synthesis of palladium (Pd) and platinum (Pt) nanoparticles from plants and microbes has captured the attention of many researchers because it is economical, sustainable and eco-friendly. Plant and their parts are known to have various kinds of primary and secondary metabolites which reduce the metal salts to metal nanoparticles. Shape, size and stability of Pd and Pt nanoparticles are influenced by pH, temperature, incubation time and concentrations of plant extract and that of the metal salt. Pd and Pt nanoparticles are broadly used as catalyst, as drug, drug carrier and in cancer treatment. They have shown size- and shape-dependent specific and selective therapeutic properties. In this review, we have discussed the biogenic fabrication of Pd/Pt nanoparticles, their potential application as catalyst, medicine, biosensor, medical diagnostic and pharmaceuticals.

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Section: Reviewmentioning

confidence: 99%

Green Synthesis, Characterization and Uses of Palladium/Platinum Nanoparticles

2016

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“…Platinum-based NPs with attractive electrocatalytic properties [23,24] can function as catalysts and have therapeutic applications. They induce apoptosis by targeting specific signaling pathways [25], and they induce cytotoxicity in human colon carcinoma HT29 and Caco-2 cell lines, as well as the death of cervical cancer cells through mitotic G2 phase (G2/M) phase arrest [5,26]. Furthermore, PtNPs induce DNA damage in human cancerous and normal cells including colon cancer [27], monocytic [22], U2OS [18], cancer (LNCaP) [17], trophoblasts [28], and bronchial epithelial [29] cells.…”

Section: Introductionmentioning

confidence: 99%

Anisotropic Platinum Nanoparticle-Induced Cytotoxicity, Apoptosis, Inflammatory Response, and Transcriptomic and Molecular Pathways in Human Acute Monocytic Leukemia Cells

Gurunathan

Jeyaraj

et al. 2020

IJMS

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The thermoplasmonic properties of platinum nanoparticles (PtNPs) render them desirable for use in diagnosis, detection, therapy, and surgery. However, their toxicological effects and impact at the molecular level remain obscure. Nanotoxicology is mainly focused on the interactions of nanostructures with biological systems, particularly with an emphasis on elucidating the relationship between the physical and chemical properties such as size and shape. Therefore, we hypothesized whether these unique anisotropic nanoparticles could induce cytotoxicity similar to that of spherical nanoparticles and the mechanism involved. Thus, we synthesized unique and distinct anisotropic PtNPs using lycopene as a biological template and investigated their biological activities in model human acute monocytic leukemia (THP-1) macrophages. Exposure to PtNPs for 24 h dose-dependently decreased cell viability and proliferation. Levels of the cytotoxic markers lactate dehydrogenase and intracellular protease significantly and dose-dependently increased with PtNP concentration. Furthermore, cells incubated with PtNPs dose-dependently produced oxidative stress markers including reactive oxygen species (ROS), malondialdehyde, nitric oxide, and carbonylated protein. An imbalance in pro-oxidants and antioxidants was confirmed by significant decreases in reduced glutathione, thioredoxin, superoxide dismutase, and catalase levels against oxidative stress. The cell death mechanism was confirmed by mitochondrial dysfunction and decreased ATP levels, mitochondrial copy numbers, and PGC-1α expression. To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2. PtNPs could activate ERS and apoptosis mediated by mitochondria. A proinflammatory response to PtNPs was confirmed by significant upregulation of interleukin-1-beta (IL-1β), interferon γ (IFNγ), tumor necrosis factor alpha (TNFα), and interleukin (IL-6). Transcriptomic and molecular pathway analyses of THP-1 cells incubated with the half maximal inhibitory concentration (IC50) of PtNPs revealed the altered expression of genes involved in protein misfolding, mitochondrial function, protein synthesis, inflammatory responses, and transcription regulation. We applied transcriptomic analyses to investigate anisotropic PtNP-induced toxicity for further mechanistic studies. Isotropic nanoparticles are specifically used to inhibit non-specific cellular uptake, leading to enhanced in vivo bio-distribution and increased targeting capabilities due to the higher radius of curvature. These characteristics of anisotropic nanoparticles could enable the technology as an attractive platform for nanomedicine in biomedical applications.

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“…[22] Many preclinical studies . [24] Withania somnifera: Withania somnifera is a medicinal shrub geographically located in the Indian sub continent. It is a key ingredient in many ayurvedic and Siddha preparations.…”

Section: Curcuma Longamentioning

confidence: 99%