<i>Burkholderia thailandensis</i> Isolated from the Environment, United States

Hall, Carina M.; Stone, Nathan E.; Martz, Madison; Hutton, Shelby M.; Santana-Propper, Ella; Versluis, Lora; Guidry, Kieston; Ortiz, Marielisa; Busch, Joseph D.; Maness, Trevor; Stewart, Jonathan; Sidwa, Tom; Gee, Jay E.; Elrod, Mindy G.; Petras, Julia K.; Ty, Maureen; Gulvik, Christopher A.; Weiner, Zachary P.; Salzer, Johanna S.; Hoffmaster, Alex R.; Rivera-Garcia, Sarai; Keim, Paul; Kieffer, Amanda; Sahl, Jason W.; Soltero, Fred; Wagner, David M.

doi:10.3201/eid2903.221245

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…12 ), suggesting that these overlapping bacteria were more reliable. It should be noted that studies have suggested that the characteristic bacteria we found, such as Burkholderia 27 and Ralstonia 28 , are easy to grow and have a high risk of waterborne genera and oral contaminants, although studies have also reported the presence of these bacteria in the oral cavity 29 , 30 . These disputes may be related to the molecular definition of the species, or to this particular population and their environment/habits, besides the possibility of contamination.…”

Section: Discussionmentioning

confidence: 72%

The recovery of the microbial community after plaque removal depends on periodontal health status

Li,

Yu,

Zhang

et al. 2023

npj Biofilms Microbiomes

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Plaque accumulation and microbial community changes are important causes of periodontal disease. Cleaned plaque microorganisms will reattach to form biofilms, but the recovery and outcome of plaque microbial communities in different periodontal health states remain unknown. In this study, we tracked the biofilm remodeling process in 206 dental plaque samples from 40 healthy periodontal, gingivitis and periodontitis volunteers at 6 time points before and after supragingival scaling. We found that microbial communities of different periodontal states changed asynchronously during the process, and the more severe the periodontal disease condition, the more lagged the recovery of plaque microorganisms to their original state after cleaning; this reflected a higher degree of plaque development in periodontitis samples. The plaque index and bleeding index were significantly correlated with plaque recovery, especially the recovery of bacteria such as Abiotrophia and Capnocytophaga. Meanwhile, we found that the microbial community structure of different periodontal health states was most similar at the Day 3 after plaque cleaning, and the communities gradually differentiated and developed in different directions. Abiotrophia and other bacteria might play an important role in determining the development trend of plaque biofilms. The discovery of specific time points and bacteria was of great value in clarifying the pathogenesis of periodontal disease and in seeking targets for prevention and treatment.

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Section: Discussionmentioning

confidence: 72%

The recovery of the microbial community after plaque removal depends on periodontal health status

Li,

Yu,

Zhang

et al. 2023

npj Biofilms Microbiomes

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“…In regions where the disease is/was not endemic, like the continental US, physicians are not familiar with disease symptomatology thus melioidosis may be given little consideration during initial diagnoses. Further, automated systems that perform bacterial identification may misidentify B. pseudomallei [14]. Therefore, accurate identification of melioidosis cases should be urged among healthcare providers, including the use of culture methods which are still considered the gold standard for the diagnosis of melioidosis which provides conclusive evidence for the presence of the pathogen.…”

Section: Disease Awareness and Diagnosismentioning

confidence: 99%

“…Further, automated systems that perform bacterial identification may misidentify B . pseudomallei [ 14 ]. Therefore, accurate identification of melioidosis cases should be urged among healthcare providers, including the use of culture methods which are still considered the gold standard for the diagnosis of melioidosis which provides conclusive evidence for the presence of the pathogen.…”

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confidence: 99%

The public health significance of finding autochthonous melioidosis cases in the continental United States

Torres

2023

PLoS Negl Trop Dis

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Recently, the pathogen that causes melioidosis, Burkholderia pseudomallei, was found in the Gulf Coast region of Mississippi, United States of America, associated with human cases and as bacteria in the soil of affected areas. Therefore, the Centers for Disease Control and Prevention has declared the pathogen as endemic in the continental United States for the first time. This viewpoint discusses some issues that the research, public health communities, and government agencies need to address.

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“…Burkholderia thailandensis, an opportunistic pathogen which only rarely causes human infections, is closely related to B. pseudomallei, and is similarly found in the environment. B. thailandensis has been isolated from water in Texas and Puerto Rico and from the soil in Mississippi, demonstrating an environment suitable for Burkholderia species colonization in parts of the Southern United States and in outlying territories (Hall et al, 2023). Interestingly, climate change appears to play a role in the increased range and magnitude of infections by these bacteria (Gassiep et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Detection of low-level animal-to-animal transmission in BALB/c mouse models of melioidosis

Klimko,

Barnes,

Rill

et al. 2023

Front. Bacteriol.

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Burkholderia pseudomallei, the causative agent of melioidosis, has two phases of infection. The acute phase occurs shortly after infection and is associated with bacterial sepsis, potentially leading to death, whilst the chronic phase occurs when infection persists for longer periods or is asymptomatic for months or years. BALB/c mice are more susceptible to melioidosis compared to C57BL/6 mice and are routinely models for the acute phase of infection. However, in some instances when medical countermeasures are being evaluated, mice continue to succumb to disease throughout the course of the experimental infection. Whilst B. pseudomallei is not known to be transmitted from mouse-to-mouse, we hypothesized that mice that have recovered from infection after medical countermeasure intervention may become reinfected from chronically infected mice. We tested this hypothesis by cohousing naïve mice with mice exposed to B. pseudomallei by the inhalational or intraperitoneal routes in either static or ventilated caging. Mice that were exposed to aerosolized B. pseudomallei transmitted the bacterium to approximately 4% of their naïve cagemates, whereas mice that were infected by the intraperitoneal route transmitted to approximately 8% of their naïve cagemates. Whilst the exact route of transmission remains to be determined, the results of this study showed that low levels of mouse-to-mouse transmission of B. pseudomallei are possible. We conclude that although the chance of reinfection is low amongst mice housed in the same cage, this possible scenario should be considered when interpreting data from the BALB/c mouse model of melioidosis in lengthy studies.

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Burkholderia thailandensis Isolated from the Environment, United States

Cited by 8 publications

References 14 publications

The recovery of the microbial community after plaque removal depends on periodontal health status

The recovery of the microbial community after plaque removal depends on periodontal health status

The public health significance of finding autochthonous melioidosis cases in the continental United States

Detection of low-level animal-to-animal transmission in BALB/c mouse models of melioidosis

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