Camellia sinensis Prevents Perinatal Nicotine‐Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns

Abstract

Nicotine exposure during pregnancy induces oxidative stress and leads to behavioral alterations in early childhood and young adulthood. The current study aimed to investigate the possible protective effects of green tea (Camellia sinensis) against perinatal nicotine-induced behavioral alterations and oxidative stress in mice newborns. Pregnant mice received 50 mg/kg C. sinensis on gestational day 1 (PD1) to postnatal day 15 (D15) and were subcutaneously injected with 0.25 mg/kg nicotine from PD12 to D15. Nicotine-exposed newborns showed significant delay in eye opening and hair appearance and declined body weight at birth and at D21. Nicotine induced neuromotor alterations in both male and female newborns evidenced by the suppressed righting, rotating, and cliff avoidance reflexes. Nicotine-exposed newborns exhibited declined memory, learning, and equilibrium capabilities, as well as marked anxiety behavior. C. sinensis significantly improved the physical development, neuromotor maturation, and behavioral performance in nicotine-exposed male and female newborns. In addition, C. sinensis prevented nicotine-induced tissue injury and lipid peroxidation and enhanced antioxidant defenses in the cerebellum and medulla oblongata of male and female newborns. In conclusion, this study shows that C. sinensis confers protective effects against perinatal nicotine-induced neurobehavioral alterations, tissue injury, and oxidative stress in mice newborns.

Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring

“…The impact of TZ on the nervous system was further investigated via assessment of the fear and anxiety reflex and locomotor activity. Recently, we reported the correlation between oxidative stress triggered by perinatal exposure to different agents and neurobehavioral alterations in mice newborns [27,28]. Here, the newborns exposed to TZ needed a shorter time to explore the open arm of the maze, whereas the time taken in the closed arm was longer than that of the control mice, demonstrating anxiety and fear.…”

African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats

“…For example, the beneficial role of citrus fruit-derived flavonoid (diosmin) in ameliorating and preventing methotrexate-induced oxidative and inflammatory markers, suggesting the promising protective role of diosmin against methotrexate-induced toxicities in patients with cancer and autoimmune diseases have been reported [ 105 ]. Similarly, the protective effects of green tea ( Camellia sinensis ) on nicotine exposure-induced oxidative damage in mice leading to behavioral alterations including physical development, neuromotor maturation, and behavioral performance in newborn male and female mice have been demonstrated [ 106 ]. In another study, the cardioprotective role of the flavonoid and phenolic contents of Murraya koenigii (L.) Spreng.…”

Deleterious effects of perinatal exposure to potassium bromate on the development of offspring of Swiss mice

“…This damage could be a direct result of KBrO 3 -induced oxidative stress and depleted GSH content. A direct relationship between oxidative stress and behavioral changes has been documented in different studies (Ajarem et al, 2017; da-Rosa et al, 2012; Tasset et al, 2008). Oxidative stress may induce neurodegeneration in the CNS and consequently provoke abnormal behavioral changes in adult rodents (Ajarem et al, 2017; Selvakumar et al, 2013).…”

“…A direct relationship between oxidative stress and behavioral changes has been documented in different studies (Ajarem et al, 2017; da-Rosa et al, 2012; Tasset et al, 2008). Oxidative stress may induce neurodegeneration in the CNS and consequently provoke abnormal behavioral changes in adult rodents (Ajarem et al, 2017; Selvakumar et al, 2013). Accordingly, bromate has been reported to induce pathological changes in different brain regions of adult mice and subsequently induce behavioral alterations (Ajarem et al, 2016).…”