<i>Campylobacter jejuni—</i>An Emerging Foodborne Pathogen

Altekruse, Sean F.; Stern, Norman J.; Fields, Patricia I.; Swerdlow, David L.

doi:10.3201/eid0501.990104

Cited by 777 publications

(553 citation statements)

References 60 publications

Supporting

Mentioning

520

Contrasting

Unclassified

Order By: Relevance

“…and pathogenic E. coli residing in the gut micro-flora of animals (Altekruse et al, 1999;Engberg et al, 2006;McDermott, 2006). Salmonella has main reservoirs in cattle, pig, chicken and turkey, Campylobacter spp.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Impact of antimicrobial usage on the transmission dynamics of antimicrobial resistant bacteria among pigs

Abatih

Alban

Ersbøll

et al. 2009

Journal of Theoretical Biology

View full text Add to dashboard Cite

There is increasing evidence showing that antimicrobial consumption provides a powerful selective force that promotes the emergence of resistance in pathogenic, commensal as well as zoonotic bacteria in animals. The main aim of this study was to develop a modeling framework that can be used to assess the impact of antimicrobial usage in pigs on the emergence and transmission of resistant bacteria within a finisher pig farm. The transmission dynamics of drug-sensitive and drug-resistant bacteria among pigs in the herd were characterized by studying the local and global stability properties of steady state solutions of the system. Numerical simulations demonstrating the influence of factors such as initial prevalence of infection, presence of pre-existing antimicrobial resistant mutants, and frequency of treatment on Preprint submitted to 22 September 2008 A c c e p t e d m a n u s c r i p tpredicted prevalence were performed. Sensitivity analysis revealed that two parameters had a huge influence on the predicted proportion of pigs carrying resistant bacteria: a) the transmission coefficient between uninfected pigs and those infected with drug-resistant bacteria during treatment (β 2 ) and after after treatment stops (β 3 ), and b) the spontaneous clear-out rate of drug-resistant bacteria during treatment (γ 2 ) and immediately after treatment stops (γ 3 ). Control measures should therefore be geared towards reducing the magnitudes of β 2 and β 3 or increasing those of γ 2 and γ 3 .

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

Impact of antimicrobial usage on the transmission dynamics of antimicrobial resistant bacteria among pigs

Abatih

Alban

Ersbøll

et al. 2009

Journal of Theoretical Biology

View full text Add to dashboard Cite

show abstract

“…The human pathogen Campylobacter jejuni is one of the most important causes of bacterial gastroenteritis worldwide (Altekruse et al, 1999). The natural habitat of C. jejuni is the intestine of warm-blooded animals and a wide variety of watery environmental sources (Diergaardt et al, 2004;Rosef et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Functional analysis of a Campylobacter jejuni alkaline phosphatase secreted via the Tat export machinery

et al. 2008

View full text Add to dashboard Cite

“…There are approximately 2.1 to 2.4 million cases of human campylobacteriosis each year in the United States, and C. jejuni causes 46% of all laboratoryconfirmed cases of bacterial gastroenteritis. C. jejuni infections are followed in prevalence by Salmonella (28%), Shigella (17%), and Escherichia coli O157 (5%) infections (1). Because of the high rate of diarrheal illness caused worldwide by foodborne bacteria and the severity of the infections, both in human suffering and economic loss, it is important to develop means to control the transmission of the bacteria from food, particularly poultry, to humans.…”

mentioning

confidence: 99%

Stable Concentrated Emulsions of the 1-Monoglyceride of Capric Acid (Monocaprin) with Microbicidal Activities against the Food-Borne Bacteria Campylobacter jejuni , Salmonella spp., and Escherichia coli

Thormar

Hilmarsson

Bergsson

2006

Appl Environ Microbiol

111

View full text Add to dashboard Cite

Of 11 fatty acids and monoglycerides tested against Campylobacter jejuni, the 1-monoglyceride of capric acid (monocaprin) was the most active in killing the bacterium. Various monocaprin-in-water emulsions were prepared which were stable after storage at room temperature for many months and which retained their microbicidal activity. A procedure was developed to manufacture up to 500 ml of 200 mM preconcentrated emulsions of monocaprin in tap water. The concentrates were clear and remained stable for at least 12 months. They were active against C. jejuni upon 160-to 200-fold dilution in tap water and caused a >6-to 7-log 10 reduction in viable bacterial count in 1 min at room temperature. The addition of 0.8% Tween 40 to the concentrates as an emulsifying agent did not change the microbicidal activity. Emulsions of monocaprin killed a variety of Campylobacter isolates from humans and poultry and also killed strains of Campylobacter coli and Campylobacter lari, indicating a broad anticampylobacter activity. Emulsions of 1.25 mM monocaprin in citrate-lactate buffer at pH 4 to 5 caused a >6-to 7-log 10 reduction in viable bacterial counts of Salmonella spp. and Escherichia coli in 10 min. C. jejuni was also more susceptible to monocaprin emulsions at low pH. The addition of 5 and 10 mM monocaprin emulsions to Campylobacter-spiked chicken feed significantly reduced the bacterial contamination. These results are discussed in view of the possible utilization of monocaprin emulsions in controlling the spread of food-borne bacteria from poultry to humans.

show abstract

Campylobacter jejuni—An Emerging Foodborne Pathogen

Cited by 777 publications

References 60 publications

Impact of antimicrobial usage on the transmission dynamics of antimicrobial resistant bacteria among pigs

Impact of antimicrobial usage on the transmission dynamics of antimicrobial resistant bacteria among pigs

Functional analysis of a Campylobacter jejuni alkaline phosphatase secreted via the Tat export machinery

Stable Concentrated Emulsions of the 1-Monoglyceride of Capric Acid (Monocaprin) with Microbicidal Activities against the Food-Borne Bacteria Campylobacter jejuni , Salmonella spp., and Escherichia coli

Contact Info

Product

Resources

About