<i>Candida glabrata</i>: Emerging pathogen in neonatal sepsis

Baradkar, VP; Mathur, M; Kumar, S; Rathi, M

doi:10.4103/1755-6783.43070

Cited by 17 publications

(29 citation statements)

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“…This corroborates well with the results of other authors. [15161718] Striking feature of the present study was isolation of C. parapsilosis (25.0%) and C. tropicalis (21.97%) as the most common NAC species.…”

Section: Discussionmentioning

confidence: 63%

Emergence of non-albicans candida species in neonatal candidemia

et al. 2013

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Background:Candida species are one of the most common causes of blood stream infections among neonates and account for 9-13% of such infections. Although Candida albicans remains the most common fungal isolate from neonatal candidemia, longitudinal studies have detected a shift towards non-albicans Candida (NAC) species.Aim:To examine the prevalence and epidemiology of candidemia among infants admitted to our hospital.Materials and Methods:Blood samples were collected from 548 neonates and only those which yielded pure growth of Candida spp. were included in the study. The isolates were identified as per standard mycological techniques and antifungal susceptibility (AFS) was done by disc diffusion method.Results:Of the total 132 neonates included in the study, NAC species were responsible for 80.30% cases with C. parapsilosis (25.0%) and C. tropicalis (21.97%) as the most predominant species; whereas 19.70% of cases were caused by C. albicans. AFS results revealed that 65.91, 73.49, and 96.21% isolates were sensitive to fluconazole (FLK), itraconazole (ITR), and amphotericin B (AMB), respectively.Conclusion:Candidemia in neonates is an ominous prognostic sign and is an important entity in our hospital. Strict infection control strategies, appropriate preventive and therapeutic measures such as prophylactic antifungal use and a restrictive policy of antibiotic use should be implemented.

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Section: Discussionmentioning

confidence: 63%

Emergence of non-albicans candida species in neonatal candidemia

et al. 2013

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“…During the past decade colonization and candidaemia with non-albicans Candida species has risen dramatically with high rates of carriage in hospitalized infants including neonates admitted to NICU [2,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants

et al. 2011

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BackgroundThere is evidence that Candida colonization contributes to increasing invasion of candidiasis in hospitalized neonates. Few studies investigated the epidemiology and risk factors of Candida colonization among hospitalized and non-hospitalized infants. This prospective study investigated the major epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants.MethodsInfants aged one year or less who were examined at the pediatrics outpatient clinic or hospitalized at the Jordan University Hospital, Amman, Jordan, were included in this study. Culture swabs were collected from oral and rectal sites and inoculated on Sabouraud dextrose agar. All Candida isolates were confirmed by the Remel RapID yeast plus system, and further investigated for specific virulence factors and antifungal susceptibility MIC using E-test. Genotyping of C. albicans isolates was determined using random amplified polymorphic DNA (RAPD) analysis method.ResultsA total of 61/492 (12.4%) infants were colonized with Candida species by either their oral/rectal sites or both. Rectal colonization was significantly more detected than oral colonization (64.6% verses 35.4%), particularly among hospitalized infants aged more than one month. The pattern and rates of colonization were as follows: C. albicans was the commonest species isolated from both sites and accounted for 67.1% of all isolates, followed by C.kefyr (11.4%), each C. tropicalis and C. glabrata (8.9%) and C. parapsilosis (3.8%).A various rates of Candida isolates proved to secrete putative virulence factors in vitro; asparatyl proteinase, phospholipase and hemolysin. C. albicans were associated significantly (P < 0.05) with these enzymes than other Candida species. All Candida isolates were susceptible to amphotericin B and caspofungin, whereas 97% of Candida species isolates were susceptible to fluconazole using E-test.The genetic similarity of 53 C. albicans isolates as demonstrated by dendrogram revealed the presence of 29 genotypes, and of these one genotype accounted for 22% of the isolates.ConclusionThis study presents important epidemiological features of Candida colonization of Jordanian infants.

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“…It has presumably emerged predominantly among patients with hematological malignancies possibly due to increased use of azole prophylaxis (11); however, in the present study, none of the patients with C. glabrata candidemia had any type of malignancy. In a study carried out on neonatal sepsis, prior exposure to antibiotics, low birth weight, and prematurity have been identified as specific risk factors for all cases of C. glabrata candidemia in neonates (12). Some studies have noted that C. glabrate may be more prevalent associated with increase in medically complex pediatric patients such as gastrointestinal disorders (13).…”

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confidence: 99%

Candidemia in Children Caused by Uncommon Species of Candida

Charsizadeh

Mirhendi

Nikmanesh

et al. 2018

Arch Pediatr Infect Dis

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Background: The aspects of the epidemiology of bloodstream Candida infections including clinical features, the causal agents, underlying conditions, and risk factors have not been well-defined in Iranian pediatric patients. The aim of this observational study was to identify uncommon Candida species isolated from blood and other normally sterile specimens of the neonates and children admitted to intensive care units at Children's medical center, Tehran, Iran. Methods: The study was carried out prospectively on patients < 16 years, who were hospitalized in Children's medical center, Tehran, Iran, during 25 months, from June 2014 to July 2016. Blood and other normally sterile specimens were collected from 6,075 pediatric patients and only pure growth of yeasts were included the study. The yeast isolates were subjected to DNA extraction, PCR of ITSregion, and sequencing followed by Blast analysis to accurately identify the species. Results: A total of 16 out of 136 isolates were recognized as uncommon or rare Candida species. According to the sequence analysis, these isolates were identified as C. orthopsilosis (N = 5, 3.7%), C. glabrate (n = 4, 2.5%), C. dubliniensis (n = 2, 1.5%), C. lusitaniae (n = 2, 1.5%), C. kefyr (n = 2, 1.5%), and C. intermedia (n = 1, 0.75%) Conclusions: Candida species, which were once considered harmless, have now been recognized as causative agents of candidemia. It is essential to consider, manage, and control the conditions that lead to the development of these unusual but severe cases of candidemia.

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Candida glabrata: Emerging pathogen in neonatal sepsis

Cited by 17 publications

References 0 publications

Emergence of non-albicans candida species in neonatal candidemia

Emergence of non-albicans candida species in neonatal candidemia

Epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants

Candidemia in Children Caused by Uncommon Species of Candida

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