2015
DOI: 10.1002/jcb.25258
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Chlamydia trachomatis Inclusion Disrupts Host Cell Cytokinesis to Enhance Its Growth in Multinuclear Cells

Abstract: Chlamydia trachomatis, the leading cause of bacterial sexually transmitted infections, disrupts cytokinesis and causes significant multinucleation in host cells. Here, we demonstrate that multinuclear cells that result from unsuccessful cell division contain significantly higher Golgi content, an important source of lipids for chlamydiae. Using immunofluorescence and fluorescent live cell imaging, we show that C. trachomatis in multinuclear cells indeed intercept Golgi-derived lipid faster than in mononuclear … Show more

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Cited by 10 publications
(10 citation statements)
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References 48 publications
(86 reference statements)
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“…It is likely that Chlamydia spp. finely tune cell cycle progression to maximize nutrient acquisition at specific stages of development 114 .…”
Section: Modifying the Host Responsementioning
confidence: 99%
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“…It is likely that Chlamydia spp. finely tune cell cycle progression to maximize nutrient acquisition at specific stages of development 114 .…”
Section: Modifying the Host Responsementioning
confidence: 99%
“…C. trachomatis also prevents centrosome clustering during mitosis in a CPAF-independent manner, presumably through the Inc-mediated tethering of centrosomes to the inclusion 51,111,115,116 . The cumulative effect of centro some amplification, early mitotic exit and errors in centrosome-positioning, halts cytokinesis, which results in multinucleated cells 111,114 . Multinucleation increases the contents of the Golgi apparatus, which enables Chlamydia spp.…”
Section: Modifying the Host Responsementioning
confidence: 99%
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“…Cytomegalovirus CMV/HHV5 infection caused transcriptomic misregulations in cell cycle and mitosis genes, and produced a pseudo‐mitosis state in the infected cells (Hertel & Mocarski, ). Chlamydia trachomatis disrupted cytokinesis of the host cells and caused aneuploidy with multinuclei (Sun, Sin, Poirier, & Harrison, ). Expression of Helicobacter pylori oncoprotein CagA caused (a) uncontrolled cell proliferation by activating the oncoprotein SHP‐2 and (b) spindle misorientation at the onset of anaphase and chromosomal segregation errors with abnormal division axis (Umeda et al, ).…”
Section: The “Amyloid‐beta Accumulation Cycle”mentioning
confidence: 99%
“…Cytomegalovirus CMV/HHV5 infection caused transcriptomic misregulations in cell cycle and mitosis genes, and produced a pseudo-mitosis state in the infected cells (Hertel & Mocarski, 2004). Chlamydia trachomatis disrupted cytokinesis of the host cells and caused aneuploidy with multinuclei (Sun, Sin, Poirier, & Harrison, 2016). Expression of Helicobacter pylori oncoprotein…”
Section: Infection With Ad-associated Pathogens Can Cause Mitotic Rmentioning
confidence: 99%