(-)-<i>cis</i>-Carveol, a Natural Compound, Improves<i>β</i>-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

Hrițcu, Lucian; Boiangiu, Răzvan Ştefan; Morais, Mayara Castro de; Sousa, Damião Pergentino de

doi:10.1155/2020/8082560

Cited by 15 publications

(10 citation statements)

References 54 publications

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“…The spatial learning and memory of the rats were evaluated using a protocol of the radial arm maze (RAM) task described for the first time by Olton and Samuelson [ 50 ] and modified by Hritcu et al [ 51 ]. Our RAM was built from grey-translucent Plexiglass and consisted of 8 arms in size of 40 × 10 × 20 cm (L × l × h, numbered from 1 to 8) radially arranged around a circular arena with 20 cm in diameter.…”

Section: Methodsmentioning

confidence: 99%

Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ25-35-Induced Rat Model of Alzheimer’s Disease

et al. 2020

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The nicotinic derivatives, cotinine (COT), and 6-hydroxy-L-nicotine (6HLN), showed promising cognitive-improving effects without exhibiting the nicotine’s side-effects. Here, we investigated the impact of COT and 6HLN on memory impairment and the oxidative stress in the Aβ25-35-induced rat model of Alzheimer’s disease (AD). COT and 6HLN were chronically administered to Aβ25-35-treated rats, and their memory performances were assessed using in vivo tasks (Y-maze, novel object recognition, and radial arm maze). By using in silico tools, we attempted to associate the behavioral outcomes with the calculated binding potential of these nicotinic compounds in the allosteric sites of α7 and α4β2 subtypes of the nicotinic acetylcholine receptors (nAChRs). The oxidative status and acetylcholinesterase (AChE) activity were determined from the hippocampal tissues. RT-qPCR assessed bdnf, arc, and il-1β mRNA levels. Our data revealed that COT and 6HLN could bind to α7 and α4β2 nAChRs with similar or even higher affinity than nicotine. Consequently, the treatment exhibited a pro-cognitive, antioxidant, and anti-AChE profile in the Aβ25-35-induced rat model of AD. Finally, RT-qPCR analysis revealed that COT and 6HLN positively modulated the bdnf, arc, and il-1β genes expression. Therefore, these nicotinic derivatives that act on the cholinergic system might represent a promising choice to ameliorate AD conditions.

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Section: Methodsmentioning

confidence: 99%

Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ25-35-Induced Rat Model of Alzheimer’s Disease

et al. 2020

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“…Investigation of neuroprotective activity of (-)-cis-carveol against β-amyloid-peptide 1-42 (Aβ1-42)-induced AD demonstrated that it significantly improved memory deficits induced by Aβ1-42 and investigated using Y-maze and radial arm maze tests. Furthermore, it significantly decreased Aβ1-42-induced oxidative stress indicating an important candidate to decrease symptoms of AD (59). ISSN: 2321-3647 www.ajphr.com 19…”

Section: Neuroprotective Activitiesmentioning

confidence: 95%

Monoterpenoids: A Neuropharmacological Approach

Buch¹,

Airao²,

Sharma³

et al. 2020

AJPHR

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Monoterpenoids, being a valuable component of essential oils, constitute important groups of natural compounds. They contain two isoprenoid units in their structure. Monoterpenoids are the secondary metabolites of the plants and they do not exert primary function in the plants. Owing to their higher abundance in the plant kingdom, they find wide application in the perfumery industry, food, and health care products for human beings. Monoterpenoids either in direct form or modified form exert diverse pharmacological effects. The present review reports wide pharmacological activities of monoterpenoids like learning and memory enhancer, antidepressant, anxiolytic, antinociceptive, anticonvulsant, and neuroprotective indicating the promising potential of monoterpenoids to treat a wide range of complex diseases.

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“…In detail, most of the compounds were pushing the cases of early and intermediate time points to the I and IV quadrants, while minor speciation of alkenes limited the cases of the end point on the middle of the left side quadrants. Besides, the terpenes and terpenoids describing the early and intermediate samplings majorly were those famous for their strong antimicrobial activity, e.g., Thymol, beta-Phellandrene, and Thujol [25], while the VOCs describing the end point cases possess an anti-oxidant nature, e.g., p-Cymene [60], trans-3-(10)-Caren-2-ol [61], and p-Mentha-1(7),8(10)-dien-9-ol (cis-Carveol) [62]. Lastly, it is interesting to observe even that 4-acetyl-1-Methylcyclohexene, which is a major compound derived from D-Limonene oxidation but toxic for host cells [63], was not a descriptor of end point cases, meaning that it was depleted during fermentation and somehow converted by colonic bacteria.…”

Section: Time-dependent Discrimination Of Alkenesmentioning

confidence: 99%

Multiunit In Vitro Colon Model for the Evaluation of Prebiotic Potential of a Fiber Plus D-Limonene Food Supplement

Nissen

Valerii

Spisni

et al. 2021

Foods

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The search for new fiber supplements that can claim to be “prebiotic” is expanding fast, as the role of prebiotics and intestinal microbiota in well-being has been well established. This work explored the prebiotic potential of a novel fiber plus D-Limonene supplement (FLS) in comparison to fructooligosaccharides (FOS) over distal colonic fermentation with the in vitro model MICODE (multi-unit in vitro colon gut model). During fermentation, volatilome characterization and core microbiota quantifications were performed, then correlations among volatiles and microbes were interpreted. The results indicated that FLS generated positive effects on the host gut model, determining: (i) eubiosis; (ii) increased abundance of beneficial bacteria, as Bifidobacteriaceae; (iii) production of beneficial compounds, as n-Decanoic acid; (iv) reduction in detrimental bacteria, as Enterobaceteriaceae; (v) reduction in detrimental compounds, as skatole. The approach that we followed permitted us to describe the prebiotic potential of FLS and its ability to steadily maintain the metabolism of colon microbiota over time. This aspect is two-faced and should be investigated further because if a fast microbial turnover and production of beneficial compounds is a hallmark of a prebiotic, the ability to reduce microbiota changes and to reduce imbalances in the productions of microbial metabolites could be an added value to FLS. In fact, it has been recently demonstrated that these aspects could serve as an adjuvant in metabolic disorders and cognitive decline.

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(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

Cited by 15 publications

References 54 publications

Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ25-35-Induced Rat Model of Alzheimer’s Disease

Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ25-35-Induced Rat Model of Alzheimer’s Disease

Monoterpenoids: A Neuropharmacological Approach

Multiunit In Vitro Colon Model for the Evaluation of Prebiotic Potential of a Fiber Plus D-Limonene Food Supplement

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