<i>Citrus aurantium</i>Aroma for Anxiety in Patients with Acute Coronary Syndrome: A Double-Blind Placebo-Controlled Trial

Moslemi, Farhad; Alijaniha, Fatemeh; Naseri, Mohsen; Kazemnejad, Anoshirvan; Charkhkar, Mahsa; Heidari, Mohammad Reza

doi:10.1089/acm.2019.0061

Cited by 44 publications

(26 citation statements)

References 43 publications

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“…The differences between the current study and the previous one can be related to the various research population, the nature of anxiety, the acute na- ture of ACS in the current study versus chronic condition in hemodialysis patients, and the intervention protocol. Also, in the study of the effect of citrus aroma on the anxiety of ACS patients, Moslemi et al (2019) showed that the anxiety score of patients decreased significantly.…”

Section: Discussionmentioning

confidence: 98%

The Effect of Aromatherapy and the Benson Relaxation Technique on the Anxiety of Patients With Acute Coronary Syndrome: Randomized Controlled Trial

Zarghi

Ghezeljeh

2020

JCCNC

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Background: Anxiety is a common symptom in patients with the Acute Coronary Syndrome (ACS), which can threaten their quality of life. This study was done to compare the effects of aromatherapy using lavender and Benson’s relaxation technique on the anxiety of patients with ACS. Methods: In this randomized clinical trial, 96 patients with ACS were selected using consecutive sampling method from two hospitals in an urban area of Iran. The patients were randomly assigned to three groups of aromatherapy (n=32), Benson’s relaxation (n=32), and control (n=32) using the block size of six. The interventions were performed on two consecutive days, once a day for 20 min. Anxiety was measured before and immediately after the intervention using the Spielberger’s Anxiety Inventory. Data were analyzed using the Chi-square test, Fisher’s exact test, one-way Analysis Of Variance (ANOVA), Bonferroni post hoc test, and mixed-model repeated-measures ANOVA with a 3*2*2 design by the SPSS V. 16. Results: There was no statistically significant difference in state and trait anxiety scores between the groups after the intervention on different time points (P> 0.05). The time (P=0.001), group-day interaction (P=0.005), and time (pretest and posttest) and day (P=0.029) effect on state anxiety was statistically significant. The time (P<0.001) and the group-day interaction (P<0.001) effect on trait anxiety was statistically significant. Conclusion: Benson’s relaxation method and lavender aromatherapy did not significantly reduce anxiety in patients with ACS. Considering the anxiety and its complications in patients with ACS and the importance of its management, further studies are needed to determine appropriate care and treatment for these patients and reduce their anxiety.

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Section: Discussionmentioning

confidence: 98%

The Effect of Aromatherapy and the Benson Relaxation Technique on the Anxiety of Patients With Acute Coronary Syndrome: Randomized Controlled Trial

Zarghi

Ghezeljeh

2020

JCCNC

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“…These substances, especially d-limonene, modify the cell membrane of microbes and denature enzymes responsible for their germination and sporulation, showing antimicrobic and antifungal properties [ 191 , 196 ]. For these reasons, bitter orange tree’s EOs are widely sold as flavoring and preservative agents in foods and drinks [ 190 , 197 ]. Recently, a great interest in these EOs has been observed in the context of alternative medicines such as aromatherapy.…”

Section: Discussionmentioning

confidence: 99%

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

et al. 2020

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Sexual enhancers increase sexual potency, sexual pleasure, or libido. Substances increasing libido alter the concentrations of specific neurotransmitters or sex hormones in the central nervous system. Interestingly, the same pathways are involved in the mechanisms underlying many psychiatric and neurological disorders, and adverse reactions associated with the use of aphrodisiacs are strongly expected. However, sexual enhancers of plant origin have gained popularity over recent years, as natural substances are often regarded as a safer alternative to modern medications and are easily acquired without prescription. We reviewed the psychiatric and neurological adverse effects associated with the consumption of herbal aphrodisiacs Areca catechu L., Argemone Mexicana L., Citrus aurantium L., Eurycoma longifolia Jack., Lepidium meyenii Walp., Mitragyna speciosa Korth., Panax ginseng C. A. Mey, Panax quinquefolius L., Pausinystalia johimbe (K. Schum.) Pierre ex Beille, Piper methysticum G. Forst., Ptychopetalum olacoides Benth., Sceletium tortuosum (L.) N. E. Brown, Turnera diffusa Willd. ex. Schult., Voacanga africana Stapf ex Scott-Elliot, and Withania somnifera (L.) Dunal. A literature search was conducted on the PubMed, Scopus, and Web of Science databases with the aim of identifying all the relevant articles published on the issue up to June 2020. Most of the selected sexual enhancers appeared to be safe at therapeutic doses, although mild to severe adverse effects may occur in cases of overdosing or self-medication with unstandardized products. Drug interactions are more concerning, considering that herbal aphrodisiacs are likely used together with other plant extracts and/or pharmaceuticals. However, few data are available on the side effects of several plants included in this review, and more clinical studies with controlled administrations should be conducted to address this issue.

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“…Pimenta et al showed that bitter orange essential oil (inhalational administration) reduced blood pressure in patients with chronic myeloid leukemia while modifying the excitation of the CNS, thereby reducing insomnia [133]. A similar study carried out by Moslemi et al showed improvements in patients with acute coronary syndrome who were treated with essential oil [134]. Another recent trial confirmed the anxiolytic effect of bitter orange essential oil in patients undergoing coronary angiography, with a reduction of STAI scores, systolic blood pres-sure, diastolic blood pressure, and both respiratory and pulse rates [135].…”

Section: Essential Oilsmentioning

confidence: 93%

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

2021

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Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. The process entailed a search of PubMed, Scopus, and the Cochrane Library databases from 2010 to 2020. The search terms included “sleep disorder”, “insomnia”, “sedative”, “hypnotic”, “anxiety”, “anxiolytic”, and “clinical trial”, combined with the search terms “herbs” and “medicinal plants”, in addition to individual herbal medicines by both their common and scientific names. This updated review, which focuses mainly on clinical trials, includes research on 23 medicinal plants and their combinations. Essential oils and their associations have also been reviewed. The efficacy of medicinal plants depends on treatment duration, types of study subjects, administration route, and treatment method. More clinical trials with an adequate, standardized design are necessary, as are more preclinical studies to continue studying the mechanisms of action. As a result of our work, we can conclude that the 3 plants with the most potential are valerian, passionflower, and ashwagandha, with the combination of valerian with hops and passionflower giving the best results in the clinical tests.

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Citrus aurantiumAroma for Anxiety in Patients with Acute Coronary Syndrome: A Double-Blind Placebo-Controlled Trial

Cited by 44 publications

References 43 publications

The Effect of Aromatherapy and the Benson Relaxation Technique on the Anxiety of Patients With Acute Coronary Syndrome: Randomized Controlled Trial

The Effect of Aromatherapy and the Benson Relaxation Technique on the Anxiety of Patients With Acute Coronary Syndrome: Randomized Controlled Trial

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

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