<i>Clostridium difficile</i>: improving the prevention paradigm in healthcare settings

Vassallo, Angela; Tran, Mai-Chi N; Goldstein, Ellie J. C.

doi:10.1586/14787210.2014.942284

Cited by 14 publications

(7 citation statements)

References 155 publications

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“… 29 Studies have shown that unrecognized cases of CDI are admitted to health care facilities or transferred from one facility to another and may spread it within a facility via health care workers’ hands. 30 , 31 However, CDI can be prevented. Environmental contamination stems from the fecal–oral transfer of C. difficile spores from the patient to the health care workers’ hands and medical equipment leading to the ingestion of spores by other patients.…”

Section: Discussionmentioning

confidence: 99%

Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy

Poli

Matteo

Bruno

et al. 2015

RMHP

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IntroductionDespite the awareness about the increasing rates of Clostridium difficile infection (CDI) and the economic burden arising from its management (prolonged hospitalization, laboratory tests, visits, surgical treatment, environmental sanitation), few studies are available in Italy on the economic costs directly attributable to the CDI. The Florence health care system has designed a study with the aim of describing the costs attributable to the CDI and defines the incremental economic burden associated with the management of this complication.MethodsWe conducted a retrospective study in five hospitals of the Florence health care system. The enrolled population included all patients who were hospitalized during the year 2013 with a diagnosis of CDI. Of the 187 total cases reported in 2013, 69 patients were enrolled, for whom the main cause of hospitalization was directly attributable to CDI.ResultsWe enrolled 69 patients (19 males and 50 females), with a mean age of 82.16 years (minimum 46 to maximum 98). The total number of hospitalization days observed was 886 (12.8 per patient on average). The data from this study show that the mean total incremental cost for a patient with CDI was €3,270.52 per year. The hospital stay length is the most significant cost parameter, having the largest influence on the overall costs, with an impact of 87% on the total cost. The results confirm the costs for the management of CDI in five hospitals of the Florence health care system are in line with data from the international literature.ConclusionThe economic impact of CDI is most evident in the extension of the duration of hospitalization and emergency recurrences requiring new therapeutic options with the need to develop and implement new diagnostic and therapeutic algorithms in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy

Poli

Matteo

Bruno

et al. 2015

RMHP

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“…This form of obesity can be transmitted, for example, from one member of a family to another and can simulate the "hereditary" nature of the disease. According to some authors, the most radical way to prevent and treat such forms of obesity is to transplant the microbiome from a healthy donor [25][26][27][28].…”

Section: The Stage Of Digestion and Assimilation Of Nutrient Digestiomentioning

confidence: 99%

Nonspecific Energy Expenditure of the Body and Body Mass Regulation

Zagoskin

2019

JNB

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The principal possibility of nonspecific energy expenditure at all stages of the transformation of nutrients in the body is demonstrated. These stages include the processing of food in the mouth, digestion, absorption, interaction with the intestinal micro biome, and interstitial metabolic processes. Particular attention is paid to the role of nonspecific energy expenditure of the body in the regulation of body mass. The data on the pivotal role of reducing nonspecific energy expenditure in the development of obesity and associated pathological conditions are presented. The prospects for using uncouples of oxidative phosphorylation, fatty acids, carnitine, bile acids, sarcolipin and a number of other substances as regulators of the nonspecific energy expenditure and potential means of preventing and treating obesity are analyzed.

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“…A recent study found antiproliferative effects of the cell-free filtrate and the cell-free lyophilized filtrate of LAB (Pediococcus pentosaceus, Lactobacillus plantarum, and Weissella confusa) on human colorectal adenocarcinoma cell (Knecht et al, 2014). Increasing evidence also suggested that LAB including L. casei (Bignardi, 1998), L. rhamnosus (Assallo et al, 2014), L. acidophilus, all have the abilities of inhibiting tumor growth in rodents. Kahouli et alreported thatL.…”

Section: Lab In Preventing Colon Cancermentioning

confidence: 99%

Overview of Anticancer activity of Lactic Acid bacteria

Delesa¹

2017

Int. J. Adv. Res. Biol. Sci.

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Cancer vestiges one of the leading causes of deaths worldwide despite its advances treatment and detection and the conventional chemotherapeutic agents used for the treatment of cancer have non-specific toxicity toward normal body cells that cause various side effects. In addition, cancer cells are known to develop chemotherapy resistance in due course of treatment, so, it's difficult and not easy to treat cancer using normal antiviral drugs. Thus, the demand for novel anti-cancer agents is increasing important to develop novel biological control approach. Some research reports have shown the therapeutic potential of LAB against various types of cancer cell lines. This makes them promising candidates for further investigation and clinical treatments. While a myriad of healthful effects have been attributed to lactic acid bacteria (LAB), perhaps the most controversial remains that of anticancer activity. The precise mechanisms by which LAB may inhibit any cancer are currently unknown. However, such mechanisms might include: alteration of the metabolic activities of intestinal microflora; alteration of physico-chemical conditions in the colon and gut; binding and degrading potential carcinogens; quantitative and/or qualitative alterations in the intestinal microflora incriminated in producing putative carcinogen(s) and promoters; production of antitumourigenic or antimutagenic compounds; enhancing the host's immune response; and effects on physiology of the host. In this review article, we present the overview of anticancer activity of the lactic acid bacteria.

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Clostridium difficile: improving the prevention paradigm in healthcare settings

Cited by 14 publications

References 155 publications

Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy

Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy

Nonspecific Energy Expenditure of the Body and Body Mass Regulation

Overview of Anticancer activity of Lactic Acid bacteria

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