Overview of Anticancer activity of Lactic Acid bacteria

Abstract

Cancer vestiges one of the leading causes of deaths worldwide despite its advances treatment and detection and the conventional chemotherapeutic agents used for the treatment of cancer have non-specific toxicity toward normal body cells that cause various side effects. In addition, cancer cells are known to develop chemotherapy resistance in due course of treatment, so, it's difficult and not easy to treat cancer using normal antiviral drugs. Thus, the demand for novel anti-cancer agents is increasing important to develop novel biological control approach. Some research reports have shown the therapeutic potential of LAB against various types of cancer cell lines. This makes them promising candidates for further investigation and clinical treatments. While a myriad of healthful effects have been attributed to lactic acid bacteria (LAB), perhaps the most controversial remains that of anticancer activity. The precise mechanisms by which LAB may inhibit any cancer are currently unknown. However, such mechanisms might include: alteration of the metabolic activities of intestinal microflora; alteration of physico-chemical conditions in the colon and gut; binding and degrading potential carcinogens; quantitative and/or qualitative alterations in the intestinal microflora incriminated in producing putative carcinogen(s) and promoters; production of antitumourigenic or antimutagenic compounds; enhancing the host's immune response; and effects on physiology of the host. In this review article, we present the overview of anticancer activity of the lactic acid bacteria.

Potential of Lactobacillus Casei Subsp. Casei R-68 Isolated from Dadih to Prevent Cancer

“…In addition, the antimutagenic compounds of fermented milk are caused by casein contained in fermented milk products. However, the percentage of inhibition of mutagenicity by casein is very low compared with LAB cells [4].…”

Harnessing the Health and Techno-Functional Potential of Lactic Acid Bacteria: A Comprehensive Review

“…[ [109][110][111] Boosting the immune response Activation of natural killer cells and cytotoxic T lymphocytes. LABs can increase cytokines, such as TNF-α, IFN-γ, and IL-10, enhancing cellular immunity and suppressing tumor cell proliferation.…”

“…LABs can increase cytokines, such as TNF-α, IFN-γ, and IL-10, enhancing cellular immunity and suppressing tumor cell proliferation. [111,112] Production of anticancer metabolites LABs produce anticancer metabolites, such as extracellular polysaccharides, peptidoglycans, bacteriocins, and SCFAs, inhibiting cancer cell growth and inducing apoptosis. LAB-produced EPSs can suppress tumor-related enzymes, while SCFAs maintain gut health and reduce inflammation.…”