<i>Codonopsis pilosula</i>polysaccharides attenuate<i>Escherichia coli</i>-induced acute lung injury in mice

Gong, Zhiguo; Zhang, Shuangyi; Gu, Baichen; Cao, Jinshan; Mao, Wei; Yao, Yuan; Zhao, Jiamin; Ren, Peipei; Zhang, Kai; Liu, Bo

doi:10.1039/d2fo01221a

Cited by 15 publications

(9 citation statements)

References 70 publications

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“…For instance, Morchella esculenta polysaccharides can boost oxidative enzyme reactions and lower cell death, hence reducing oxidative stress [35]. Similar to this, Codonopsis pilosula polysaccharides [36] and Lentinus edodes polysaccharides [37] can prevent lung damage by inhibiting the production of pro-inflammatory cytokines, including TNF-α and IL-6. As a result, we speculated that ALP might be a useful medication for preventing ALI.…”

Section: Discussionmentioning

confidence: 85%

Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities

Lu,

Wei,

Gong

et al. 2023

Nutrients

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The objective of this study was to investigate the preventive effects of polysaccharides extracted from the roots of Arctium lappa (ALP) against acute lung injury (ALI) models induced by lipopolysaccharide (LPS). The polysaccharides were extracted and characterized, and their anti-inflammatory and antioxidant capacities were assessed. The findings demonstrated that ALP could mitigate the infiltration of inflammatory cells and reduce alveolar collapse in LPS-induced ALI in mice. The expression levels of the pro-inflammatory factor TNF-α decreased, while the anti-inflammatory factor IL-10 increased. Furthermore, the administration of ALP improved the activities of lung antioxidant enzymes, including SOD, GSH, and CAT, and lowered MDA levels. These results suggest that ALP exhibits a preventive effect on ALI and has potential as an alternative treatment for lung injury.

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Section: Discussionmentioning

confidence: 85%

Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities

Lu,

Wei,

Gong

et al. 2023

Nutrients

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“…How to prevent and deal with cow bacterial mastitis is an important problem in public health. LPS are a major component of Gram-negative bacteria, causing similar inflammatory responses to those caused by intact E.coli [ 19 ]. Some studies have shown that IL-17A is an important effector of mammary immune responses to E.coli , and local enhanced production of IL-17A can improve the outcomes of early infections [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…An important aspect of the inflammatory response is the up-regulated secretion of cytokines and chemokines. For example, the excessive production of various cytokines and chemokines plays a vital role in the pathophysiology of septic shock caused by bacterial infections [ 19 , 21 ]. Studies by Ma et al show that with the incidence of mastitis, the secretion levels of cytokines IL-1β, IL-6, and TNF-α will significantly increase, and IL-1β, IL-6, and TNF-α are important inflammatory cytokines that can trigger immune responses in organisms [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of Inflammatory Responses of Cow Mammary Epithelial Cells through MAPK Signaling Pathways of IL-17A Cytokines

Zhang,

et al. 2024

Animals

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The aim of this study is to explore the mechanism of IL-17A infection in the development of bacterial mastitis in dairy cows. In this study, RT-qPCR and ELISA were used to measure the promoting effect of IL-17A on the generation of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and chemokine (IL-8). In addition, Western blot (WB) was applied to measure the influences of IL-17A on the inflammation-related ERK and p38 proteins in the MAPK pathways. The results show that under the stimulation of LPS on cow mammary epithelial cells (CMECs), cytokines IL-1β, IL-6, IL-8, TNF-α, and IL-17A will exhibit significantly increased expression levels (p < 0.05). With inhibited endogenous expression of IL-17A, cytokines IL-1β, IL-6, IL-8, and TNF-α will present reduced genetic expression (p < 0.01), with reduced phosphorylation levels of ERK and p38 proteins in the MAPK signaling pathways (p < 0.001). Upon the exogenous addition of the IL-17A cytokine, the genetic expression of cytokines IL-1β, IL-6, IL-8, and TNF-α will increase (p < 0.05), with increased phosphorylation levels of the ERK and p38 proteins in the MAPK signaling pathways (p < 0.001). These results indicate that under the stimulation of CMECs with LPS, IL-17A can be expressed together with relevant inflammatory cytokines. Meanwhile, the inflammatory responses of mammary epithelial cells are directly proportional to the expression levels of IL-17A inhibited alone or exogenously added. In summary, this study shows that IL-17A could be used as an important indicator for assessing the bacterial infections of mammary glands, indicating that IL-17A could be regarded as one potential therapeutic target for mastitis.

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“…53,54 To the best of our knowledge, this is the first study on the effect of ACs in LIGAO on the antitussive ability and the protection of lung tissue from inflammatory injuries. Furthermore, the changes in TNF-α and IL-1β are related to the MAPK and NF-κB signaling pathway 55 and the regulatory effect of Fru-Asp on the MAPK and NF-κB signaling pathway activation are not been investigated. Thus, more studies are required to be conducted.…”

Section: Discussionmentioning

confidence: 99%

Formation of Amadori compounds in LIGAO (concentrated pear juice) processing and the effects of Fru-Asp on cough relief and lung moisturization in mice

Yang

Zhang

et al. 2022

Food Funct.

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Codonopsis pilosulapolysaccharides attenuateEscherichia coli-induced acute lung injury in mice

Abstract: Acute lung injury (ALI) is an inflammatory lung disease could be caused by bacterial infection. Lipopolysaccharide (LPS), a prototype pathogen-associated molecular pattern (PAMP) from gram-negative bacteria such as Escherichia coli...

Cited by 15 publications

References 70 publications

Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities

Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities

Regulation of Inflammatory Responses of Cow Mammary Epithelial Cells through MAPK Signaling Pathways of IL-17A Cytokines

Formation of Amadori compounds in LIGAO (concentrated pear juice) processing and the effects of Fru-Asp on cough relief and lung moisturization in mice

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