<i>Cogniauxia Podolaena</i>: Bioassay-Guided Fractionation of Defoliated Stems, Isolation of Active Compounds, Antiplasmodial Activity and Cytotoxicity

Banzouzi, J.T.; Soh, Patrice Njomnang; Mbatchi, Bernard; Cavé, A.; Ramos, Suzanne; Retailleau, Pascal; Rakotonandrasana, Olga L; Berry, Antoine; Benoit‐Vical, Françoise

doi:10.1055/s-2008-1081341

Cited by 18 publications

(12 citation statements)

References 6 publications

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“…Two natural khellactone, (+)-4′-Decanoyl-ciskhellactone (1) and (+)-3′-decanoyl-cis-khellactone (2) were isolated from the methanolic extract of the rhizomes parts of Agelica purpuraefolia (Umbelliferae) showed notable growth-inhibitory activity against CQ-sensitive strains of P. falciparum with IC 50 values from 1.5 and 2.4 μM (Chung et al 2010). Three triterpenes cucurbitacin B, cucurbitacin D, and 20-epibryonolic acid were isolated from Cogniauxia podolaena (Cucurbitaceae) were assayed for antiplasmodial activity with the IC 50 values of 1, 2, and 3 are 1.6, 4, and 2 μg/mL on FcM29, a CQ-resistant strain of P. falciparum (Banzouzi et al 2008). Subeki et al (2005) have reported that the bioassayguided fractionation of boiled aqueous extracts from the whole plant of P. niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC 50 values of 4.7 μg/mL against Babesia gibsoni and 1.4 μg/mL against P. falciparum in vitro.…”

Section: Resultsmentioning

confidence: 99%

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Bagavan¹,

Rahuman²,

Kaushik

et al. 2010

Parasitol Res

125

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Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. In the present study, ten plants were extracted with ethyl acetate and methanol and tested for their antimalarial activity against chloroquine (CQ)-sensitive (3D7) and CQ-resistant (Dd2 and INDO) strains of Plasmodium falciparum in culture using the fluorescence-based SYBR Green assay. Plant extracts showed moderate to good antiparasitic effects. Promising antiplasmodial activity was found in the extracts from two plants, Phyllanthus emblica leaf 50% inhibitory concentration (IC₅₀) 3D7: 7.25 μg/mL (ethyl acetate extract), 3.125 μg/mL (methanol extract), and Syzygium aromaticum flower bud, IC₅₀ 3D7:13 μg/mL, (ethyl acetate extract) and 6.25 μg/mL (methanol extract). Moderate activity (30-75 μg/mL) was found in the ethyl acetate and methanol extracts of Abrus precatorius (seed) and Gloriosa superba (leaf); leaf ethyl acetate extracts of Annona squamosa and flower of Musa paradisiaca. The above mentioned plant extracts were also found to be active against CQ-resistant strains (Dd2 and INDO). Cytotoxicity study with P. emblica leaf and S. aromaticum flower bud, extracts showed good therapeutic indices. These results demonstrate that leaf ethyl acetate and methanol extracts of P. emblica and flower bud extract of S. aromaticum may serve as antimalarial agents even in their crude form. The isolation of compounds from P. emblica and S. aromaticum seems to be of special interest for further antimalarial studies.

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Section: Resultsmentioning

confidence: 99%

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Bagavan¹,

Rahuman²,

Kaushik

et al. 2010

Parasitol Res

125

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“…The chloroquine-resistant strain of Plasmodium falciparum, FcM29-Cameroon was cultured continuously in a 5% CO 2 atmosphere at 37°C, as previously described (Banzouzi et al, 2008). The various fractions and the isolated compounds were screened for their antiplasmodial activity by the radioactive micro-method (Desjardins et al, 1979) with modifications (Mbatchi et al, 2006).…”

Section: Culture Of Plasmodium Falciparum and In Vitro Antiplasmodialmentioning

confidence: 99%

Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae)

Banzouzi

Soh

Ramos

et al. 2015

Journal of Ethnopharmacology

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“…is a folk medicine that has been traditionally used to treat malaria in Congo Brazzaville. Banzouzi et al [45] …”

Section: Cucurbitaceae Familymentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan¹,

Xu²,

Shi³

et al. 2018

Preprint

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in the developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2,000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to identification of several potent antimalarial compounds. The prior comprehensive review article entitled "Antimalarial activity of plant metabolites" by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literatures from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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Cogniauxia Podolaena: Bioassay-Guided Fractionation of Defoliated Stems, Isolation of Active Compounds, Antiplasmodial Activity and Cytotoxicity

Cited by 18 publications

References 6 publications

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae)

Antimalarial Activity of Plant Metabolites

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