Cordyceps militarisEnhances Cell-Mediated Immunity in Healthy Korean Men

Kang, Ho Joon; Baik, Hyun Wook; Kim, Sang Jung; Lee, Seong Gyu; Ahn, Hong Yup; Park, Ju Sang; Park, Sang Jong; Jang, Eun Jeong; Choi, Jin Young; Sung, Ji Hee; Lee, Seung Min

doi:10.1089/jmf.2014.3350

Cited by 43 publications

(29 citation statements)

References 22 publications

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“…Kwak et al [28] reported that changes in NK-cell activity were related to the level of serum IFN-γ. The changes in NK-cell activity and cytokines identified in this study are consistent with the results reported in several earlier studies [26,31,32] and cases [19,28,30,38,39]. Healthy adults who received Cordyceps militaris [31] supplements for 8 weeks or a mycelium extract of Cordyceps [32] for 8 weeks showed an increase in NK-cell activity without a change in cytokine levels, consistent with our findings in the current study.…”

Section: Discussionsupporting

confidence: 93%

“…Healthy adults who received Cordyceps militaris [31] supplements for 8 weeks or a mycelium extract of Cordyceps [32] for 8 weeks showed an increase in NK-cell activity without a change in cytokine levels, consistent with our findings in the current study. Cordyceps militaris increased IL-2 and IFN-γ levels in addition to NK-cell activity in healthy males (average age, 36.5±11.2 years) after 4 weeks of supplementation [38], but after 12 weeks of intake, only NK-cell activity was increased in healthy males and females (average age 48.9±6.7 years [31]), similar to our findings. In other studies, intake of Chlorella [28] by healthy adults (WBC counts 4,000-8,000 cells/μL) for eight weeks increased cytokine levels (IFN-γ, interleukin-1β) in addition to increasing NK-cell activity.…”

Section: Discussionsupporting

confidence: 89%

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Effects of Porphyra tenera Supplementation on the Immune System: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Jang¹,

Jung²,

Noh³

et al. 2020

Preprint

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Objective: The purpose of this study was to determine if Porphyra tenera extract (PTE) has immune-enhancing effects and is safe in healthy adults. Methods: Subjects (3x103 ≤ peripheral blood leukocyte levels < 8x103 cells/μl) who met the inclusion criteria were recruited for this study. Enrolled subjects (n=120) were randomly assigned to either the PTE group (n=60) who were given 2.5 g/day of PTE (as Porphyra tenera extract) in capsule form or the placebo group (n=60) who were given crystal cellulose capsules with the identical appearance, weight, and flavor as the PTE capsules for 8 weeks. Outcomes were assessed by measuring natural killer cell (NK-cell) activity, cytokines, and upper respiratory infection (URI), and safety parameters were assessed at baseline and 8 weeks. Results: Compared to baseline, NK cell activity (%) increased for all effector cell to target cell ratios in the PTE group after 8 weeks, but there were no changes in the placebo group (p<0.1). Subgroup analysis of 101 subjects without an URI revealed that NK-cell activity in the PTE group tended to be increased for all E:T ratios (E:T=12.5:1 p=0.068; E:T=25:1 p=0.036; E:T=50:1 p=0.081) compared to the placebo group. There was a significant difference between these two groups for the E:T=25:1 ratio, which increased from 20.3±12.0% at baseline to 23.2±12.4% after 8 weeks in the PTE group (p=0.036). There was no significant difference in levels of cytokines between these two groups. Conclusions: PTE supplementation appears to enhance immune function by improving NK-cell activity without adverse effects in healthy adults.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Effects of Porphyra tenera Supplementation on the Immune System: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Jang¹,

Jung²,

Noh³

et al. 2020

Preprint

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show abstract

Section: Introductionmentioning

confidence: 99%

“…It was reported that C. militaris fruit body extract enhances NK cell activity and T cell proliferation and partially increases Th1 cytokine secretion in healthy humans (H. J. Kang, Baik, Kim, et al, 2015). Animal studies demonstrated growth inhibitory effects of C. militaris fruit body extract on sarcoma and breast cancer; the effects are closely linked with suppression of Treg cells and increases of helper T cells, cytotoxic T cells, or NK cells (Jeong, Lee, Lee, et al, 2013;H.…”

Section: Introductionmentioning

confidence: 99%

Immunostimulatory effects of cordycepin‐enriched WIB‐801CE from Cordyceps militaris in splenocytes and cyclophosphamide‐induced immunosuppressed mice

Shin

Chung

Lee

et al. 2017

Phytotherapy Research

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The medicinal mushroom Cordyceps militaris has been reported to possess anticancer and immunomodulatory effects. We investigated the immunostimulatory effects of culture supernatant of C. militaris (WIB-801CE) by examining its in vitro enhancing effects on cell proliferation and cytokine releases in splenocytes and its in vivo effects on cyclophosphamide-induced immunosuppressed mice. WIB-801CE enhanced normal and methotrexate-induced cell proliferation.WIB-801CE significantly ameliorated interleukin (IL)-2, interferon-γ, and tumor necrosis factor-α secretion in methotrexate-induced splenocytes. Oral administration of WIB-801CE effectively increased the cyclophosphamide-suppressed splenocyte proliferation and natural killer cytotoxic activity. WIB-801CE effectively recovered cyclophosphamide-induced decreases in IL-2, interferon-γ, tumor necrosis factor-α, and IL-10 level. The collective data implicate WIB-801CE as a therapeutic candidate in ameliorating the immunosuppression through immunostimulatory properties.

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“…The OPE was acquired from Changnyeong between August and September 2012, and passed through an OPE powder manufacturing process [15]. The OPE group was received 100 mg of quercetin [15] daily for 12 weeks, while placebo group was treated with identically-packaged soft capsules containing lactose mixture [16]. …”

Section: Methodsmentioning

confidence: 99%

The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women

Kim

Yim

2016

Clin Nutr Res

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Quercetin, found abundantly in onion peel, has been known to have antioxidant and anti-obesity effects and improves endothelial function. The purpose of this study was to evaluate the effects of a quercetin-rich onion peel extract (OPE) on the inflammatory mediators in overweight and obese women. This study was a randomized double-blind, placebo-controlled study. Thirty-seven healthy overweight and obese women were randomly assigned to two groups, and one group was given a soft capsuled OPE (100 mg quercetin/day, n = 18) and the other group a same capsuled placebo (n = 19) for 12 weeks. Fat mass was measured by bioimpendance method at baseline and after 12 weeks of intervention. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured with colorimetric assay kits. The concentrations of leptin, adiponectin, visfatin, tumor necrosis factor (TNF)-α and interleukin (IL)-4 in plasma were determined by using enzyme-linked immunosorbent assay kits. Baseline characteristics of anthropometric indicators and blood metabolic profiles were not significantly different between placebo and OPE groups. Compared with baseline value, both placebo and OPE supplementation significantly decreased the percent of body fat mass and induced plasma adiponectin levels while ALT and AST activities as well as leptin, visfatin, TNF-α, and IL-4 levels in plasma were not significantly different between two groups after 12 weeks of the supplementation. These findings suggest that 12-week supplementation of OPE do not affect modulators of systemic inflammation in overweight and obese women.

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Cordyceps militarisEnhances Cell-Mediated Immunity in Healthy Korean Men

Cited by 43 publications

References 22 publications

Effects of <em>Porphyra tenera</em> Supplementation on the Immune System: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Effects of <em>Porphyra tenera</em> Supplementation on the Immune System: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Immunostimulatory effects of cordycepin‐enriched WIB‐801CE from Cordyceps militaris in splenocytes and cyclophosphamide‐induced immunosuppressed mice

The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women

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