<i>Curcuma zedoaria</i> Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties

Lobo, Richard; Prabhu, Kirti S.; Shirwaikar, Annie

doi:10.1211/jpp.61.01.0003

Cited by 103 publications

(54 citation statements)

References 37 publications

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“…The anticancer and biological properties of Curcuma zedoaria rhizomes have been extensively reported by Lobo et al [8]. However, there are very few reports on the active components responsible for the cytotoxic effects, even less on the underlying mechanism of cell death elicited by the active components [9].…”

Section: Introductionmentioning

confidence: 99%

In VitroMorphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes ofCurcuma zedoaria

Rahman

Wahab

Malek

2013

Evidence-Based Complementary and Alternative Medicine

121

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Bioassay-guided isolation of the active hexane fractions of Curcuma zedoaria led to the identification of five pure compounds, namely, curzerenone (1), neocurdione (2), curdione (3), alismol (4), and zederone (5) and a mixture of sterols, namely, campesterol (6), stigmasterol (7), and β-sitosterol (8). Alismol has never been reported to be present in Curcuma zedoaria. All isolated compounds except (3) were evaluated for their cytotoxic activity against MCF-7, Ca Ski, and HCT-116 cancer cell lines and noncancer human fibroblast cell line (MRC-5) using neutral red cytotoxicity assay. Curzerenone and alismol significantly inhibited cell proliferation in human cancer cell lines MCF-7, Ca Ski, and HCT-116 in a dose-dependent manner. Cytological observations by an inverted phase contrast microscope and Hoechst 33342/PI dual-staining assay showed typical apoptotic morphology of cancer cells upon treatment with curzerenone and alismol. Both compounds induce apoptosis through the activation of caspase-3. It can thus be suggested that curzerenone and alismol are modulated by apoptosis via caspase-3 signalling pathway. The findings of the present study support the use of Curcuma zedoaria rhizomes in traditional medicine for the treatment of cancer-related diseases. Thus, two naturally occurring sesquiterpenoids, curzerenone and alismol, hold great promise for use in chemopreventive and chemotherapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

In VitroMorphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes ofCurcuma zedoaria

Rahman

Wahab

Malek

2013

Evidence-Based Complementary and Alternative Medicine

121

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“…Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhea, cancer. C. zedoaria has been used for phytochemical and pharmacological medicine [145]. …”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Aggarwal¹,

Prasad²,

Reuter

et al. 2011

CDT

363

155

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Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed these observations and identified the molecular basis for most chronic diseases and for the associated inflammation. The transcription factor, Nuclear Factor-kappaB (NF-κB) that controls over 500 different gene products, has emerged as major mediator of inflammation. Thus agents that can inhibit NF-κB and diminish chronic inflammation have potential to prevent or delay the onset of the chronic diseases and further even treat them. In an attempt to identify novel anti-inflammatory agents which are safe and effective, in contrast to high throughput screen, we have turned to “reverse pharmacology” or “bed to benchside” approach. We found that Ayurveda, a science of long life, almost 6000 years old, can serve as a “goldmine” for novel anti-inflammatory agents used for centuries to treat chronic diseases. The current review is an attempt to provide description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit.

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“…En los últimos años, se han estudiado distintos tipos de alimentos con el propósito de conocer sus bondades médicas, como elementos antioxidantes y antiinflamatorios, que ayuden a la prevención y disminución de distintos tipos de cánceres o enfermedades crónicas, como es el caso de la Curcuma longa, la cual es una raíz de origen Hindú [2] , dicha raíz posee propiedades altamente desinflamantes, antioxidantes y antitumorales [3,4,5] c u y o elemento activo:, la curcumina [6] , produce efectos anti-inflamatorios, analgésicos, antialérgicos, citotó-xicos, hepatoprotectores, etc. [7] . Además debido a sus propiedades nutritivas (fuente de vitaminas B6 y fibra, además de altas concentraciones de magnesio, potasio y hierro) [8] , podría mejorar el estado de la sangre, de esta manera se pudiera manifestar en cambios en los espectros de absorción óptico lo cual, fue el objetivo de la presente investigación empleando un modelo animal.…”

Section: Introductionunclassified

Obtaining and Analysis of Optical Absorption Spectrum of Fisher Rat Blood with Hepatic Damage by Photoacoustic Spectroscopy

Noguez

Cano-Europa

Colín

et al. 2017

Rev. Mex. Ing. Biomed.

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Photoacoustic Spectroscopy (PAS) stand outs among Photothermal techniques due to its versatility for the characterization of different types of materials, including biological samples. In this study, were compared and analyzed by PAS, the differences between the optical absorption spectra of blood of male Fisher rats, in three cases, control (healthy rats), liver damage and liver damage treated with Curcuma longa. The experimental results show differences in the optical absorption spectra of each analysed case, therefore PAS would be proposed as a non conventional complementary technique, to study the effect of Curcuma longa in induced liver damage for an animal model.

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Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties

Abstract: This review presents the botany, chemistry, traditional uses and pharmacological data of the plant.

Cited by 103 publications

References 37 publications

In VitroMorphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes ofCurcuma zedoaria

In VitroMorphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes ofCurcuma zedoaria

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Obtaining and Analysis of Optical Absorption Spectrum of Fisher Rat Blood with Hepatic Damage by Photoacoustic Spectroscopy

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Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties

Abstract: This review presents the botany, chemistry, traditional uses and pharmacological data of the plant.

Cited by 103 publications

References 37 publications

In VitroMorphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes ofCurcuma zedoaria

In VitroMorphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes ofCurcuma zedoaria

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: &#x201C;Reverse Pharmacology&#x201D; and &#x201C;Bedside to Bench&#x201D; Approach

Obtaining and Analysis of Optical Absorption Spectrum of Fisher Rat Blood with Hepatic Damage by Photoacoustic Spectroscopy

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Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach