<i>Curvularia lunata</i> Endophthalmitis

Berbel, Rodrigo Fabri; Casella, Antônio Marcelo Barbante; Freitas, Denise de; Höfling-Lima, Ana Luísa

doi:10.1089/jop.2011.0002

Cited by 11 publications

(11 citation statements)

References 13 publications

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“…To date, there are only eleven reported cases of endophthalmitis secondary to Curvularia. [6] , [7] , [8] , [9] , [10] Among those cases, eight patients had a preceding history of cataract surgery [6] , [8] , [9] , [10] , while four had a previous history of trauma [7] , [9] , [10] . Our case is unique due to its delayed and recalcitrant course.…”

Section: Discussionmentioning

confidence: 99%

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Delayed fungal endophthalmitis secondary to Curvularia

Almeida

Chin

et al. 2016

American Journal of Ophthalmology Case Reports

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PurposeTo describe a case of fungal endophthalmitis secondary to Curvularia after cataract surgery.ObservationsThis case showed delayed and recalcitrant fungal endophthalmitis secondary to Curvularia despite treatment with pars plana vitrectomy, intravitreal antifungal therapy, and systemic antifungals.Conclusions and importanceCurvularia-associated endophthalmitis should be considered in the differential diagnosis of delayed post-cataract endophthalmitis, especially in tropical or subtropical geographical areas. Awareness and early identification, timely removal of the nidi of sequestration, and prolonged antifungal treatments are important for the eradication of Curvularia-associated endophthalmitis.

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Section: Discussionmentioning

confidence: 99%

“…Among all the cases with a preceding history of cataract surgery, the interval between surgery and initial symptom was between 1 and 5 months [6] , [8] , [9] , [10] . In our case, the interval from surgery to initial symptom was three years, an unusually delayed-onset postoperative endophthalmitis associated with Curvularia .…”

Section: Discussionmentioning

confidence: 99%

Delayed fungal endophthalmitis secondary to Curvularia

Almeida

Chin

et al. 2016

American Journal of Ophthalmology Case Reports

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“…[1][2][3][4]6,7 Some publications have shown a weak action of amphotericin B against C. lunata. [1][2][3][4]6,7 Some publications have shown a weak action of amphotericin B against C. lunata.…”

Section: Discussionmentioning

confidence: 99%

“…We report a case of C. lunata endophthalmitis associated with corneal abscess that responded well with intravitreal amphotericin B and oral itraconazole. [1][2][3][4]6,7 It is always important to suspect fungal infections when dealing with contaminated cases with dirt or vegetable material. In this eye, prompt antifungal treatment was installed according to the microbiologic results.…”

Section: Discussionmentioning

confidence: 99%

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Curvularia Lunata Endophthalmitis After Penetrating Ocular Trauma

Jaramillo

Varón²

2013

RETINAL Cases &Amp; Brief Reports

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ProlongedCurvularia EndophthalmitisDue to Organism Sequestration

et al. 2014

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urvularia is a dematiaceous or darkly pigmented fungus. Endophthalmitis due to Curvularia species is exceedingly rare, with only isolated case reports in the literature. [1][2][3][4][5][6] Large series of endogenous and exogenous fungal endophthalmitis in the United States do not mention Curvularia as a separate causative organism. [7][8][9][10] The present series of 6 cases of Curvularia endophthalmitis demonstrates the difficulty of timely and proper diagnosis and challenges in the eradication of the microorganism. MethodsAn institutional review board-approved retrospective review of the archives of the microbiology laboratory at Bascom Palmer Eye Institute from January 1, 1980, through September 30, 2013, identified all cultures positive for Curvularia. The substrate (blood agar, chocolate agar, Sabouraud agar, Lowenstein-Jensen agar, or thioglycolate broth) on which Curvularia grew IMPORTANCE Endophthalmitis caused by Curvularia is a rare condition seen after cataract surgery and trauma. The clinical course has not been described previously.OBJECTIVE To examine the clinical course of 6 postoperative and trauma-related cases of Curvularia endophthalmitis. DESIGN, SETTING, AND PARTICIPANTS Retrospective case series. We reviewed the archives of the microbiology laboratory of Bascom Palmer Eye Institute, a tertiary referral hospital, from January 1, 1980, through September 30, 2013, to identify cases of Curvularia endophthalmitis. Data collected included demographic information, the cause of endophthalmitis, presenting features, treatment course, the number of recurrences, the area of organism sequestration, and final visual outcome. EXPOSURES Trauma and cataract surgery.MAIN OUTCOMES AND MEASURES Times from the inciting event to presentation of symptoms, diagnosis, and eradication; visual acuity; and identification of the area of sequestration. RESULTSWe identified 6 patients with Curvularia endophthalmitis, including 5 who underwent cataract surgery and 1 after trauma. The diagnosis was established rapidly in the trauma case. In the postoperative cases, the time from the surgery to first symptoms ranged from 2 to 5 months; from the surgery to correct diagnosis, 7 to 24 months; and from the surgery to eradication, 8 to 27 months. Despite aggressive antifungal therapy, eradication of the infection could be achieved only by identification and removal of the nidus of sequestration. The median follow-up was 29.5 months. CONCLUSIONS AND RELEVANCEIn cases of endophthalmitis caused by Curvularia, the diagnosis and treatment are often delayed, especially in postoperative cases. The eradication of the organism requires identification and removal of the nidi of sequestration.

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Curvularia lunata Endophthalmitis

Abstract: The use of intravitreal voriconazole injection is a viable option in cases of Curvularia fungal endophthalmitis.

Cited by 11 publications

References 13 publications

Delayed fungal endophthalmitis secondary to Curvularia

Delayed fungal endophthalmitis secondary to Curvularia

Curvularia Lunata Endophthalmitis After Penetrating Ocular Trauma

ProlongedCurvularia EndophthalmitisDue to Organism Sequestration

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