<i>CYP2D6, NAT2 and CYP2EI</i> genetic polymorphisms in nonagenarians

Agúndez, José A. G.; Rodríguez, I.; Olivera, M.; Ladero, José M.; García, María del Mar Ballesteros; Ribera, Josep‐Marǐa; Benı́tez, Julio

doi:10.1093/ageing/26.2.147

Cited by 40 publications

(20 citation statements)

References 22 publications

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“…We found that the level of our GlycoAgeTest This difference could be partly due to common lifestyle between Belgium and Italy, and genetic polymorphisms (Melzer, 2008;Agundez et al, 1997;Melzer et al, 2007). It was recently documented that plasma N-glycans is affected by age, body mass index, plasma lipid profiles and smoking (Knezevic et al, 2010).…”

Section: Discussionmentioning

confidence: 72%

Serum N-glycan profile shift during human ageing

Vanhooren

Dewaele

Libert

et al. 2010

Experimental Gerontology

112

100

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Section: Discussionmentioning

confidence: 72%

Serum N-glycan profile shift during human ageing

Vanhooren

Dewaele

Libert

et al. 2010

Experimental Gerontology

112

100

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“…The CYP2E1 gene had shown to encode enzyme that is involved in the metabolism of several drugs such as paracetamol, chlorzoxazone and ethanol (Agundez et al, 1997). Investigators reported that Japanese (Kim et al, 1996) had a lower oral clearance of the chlorzoxazone (in vivo probe) when compared with Caucasians.…”

Section: Resultsmentioning

confidence: 99%

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Goh¹,

Chong²,

Chua³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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CYP2E1 PstI polymorphism G-1259C (rs3813867) genotype distributions vary significantly among different populations and are associated with both diseases, like cancer, and adverse drug effects. To date, there have been limited genotype distributions and allele frequencies of this polymorphism reported in the three major indigenous ethnic groups (KadazanDusun, Bajau, and Rungus) in Sabah, also known as North Borneo. The aim of this study was to investigate the genotype distributions and allele frequencies of the CYP2E1 PstI polymorphism G-1259C in these three major indigenous peoples in Sabah. A total of 640 healthy individuals from the three dominant indigenous groups were recruited for this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) at G-1259C polymorphic site of CYP2E1 gene was performed using the Pst I restriction enzyme. Fragments were analyzed using agarose gel electrophoresis and confirmed by direct sequencing. Overall, the allele frequencies were 90.3% for c1 allele and 9.7% for c2 allele. The genotype frequencies for c1/c1, c1/c2 and c2/c2 were observed as 80.9%, 18.8%, and 0.3%, respectively. A highly statistical significant difference (p<0.001) was observed in the genotype distributions between indigenous groups in Sabah with all Asian and non-Asian populations. However, among these three indigenous groups, there was no statistical significant difference (p>0.001) in their genotype distributions. The three major indigenous ethnic groups in Sabah show unique genotype distributions when compared with other populations. This finding indicates the importance of establishing the genotype distributions of CYP2E1 PstI polymorphism in the indigenous populations.

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“…Controls were members of faculty and hospital staff and students from the same geographical distributions as the cases. Age differences between cases and controls were not considered to influence the study because previous data showed no correlation between genotype and age [19,20]. Institutional Review Board approved the research, and informed consents were obtained from all patients and controls.…”

Section: Subjects and Methods Cases And Controlsmentioning

confidence: 99%

Role ofCYP2D6, CYP1A1, CYP2E1, GSTT1, andGSTM1 genes in the susceptibility to acute leukemias

Sayitoğlu¹,

Hatırnaz²,

Erensoy³

et al. 2006

Am. J. Hematol.

101

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Acute leukemias (ALs) are heterogeneous diseases. Functional polymorphisms in the genes encoding detoxification enzymes cause inter-individual differences, which contribute to leukemia susceptibility. The CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 polymorphisms in ALL (n = 156) and AML (n = 94) patients and 140 healthy controls were genotyped by PCR and/or PCR-RFLP using blood or bone marrow samples. No association was observed between the GSTT1 gene deletion and patients (OR = 0.8, 95% CI = 0.4-1.7 for AMLs and OR = 0.9, 95% CI ¼ 0.5-1.6 for ALLs). Patients with ALL and AML had a higher prevalence of the GSTM1 deletions compared to controls but only the difference among adult AML patients (OR = 2.1, 95% CI = 1.0-4.2) was statistically significant. The CYP2D6*3 variant allele frequency was lower in the overall acute leukemia patients (0.6%) compared to controls (P = 0.03). CYP2D6*1/*3 genotype frequency also showed a protective association in AML patients (OR = 0.09, 95% CI = 0.01-1.7; P = 0.04). We also found a risk association for CYP2E1*5 in ALL and AML (OR = 3.6, 95% CI = 1.4-9.4 and OR = 3.9, 95% CI = 1.4-10.5, respectively). No association was found for the studied CYP2D6*4, CYP1A1*2A, and GSTT1''null'' variants and the risk of acute leukemia (ALL or AML). This case-control study suggests a contribution of CYP2E1, CYP2D6, and GSTM1 ''null'' variants to the development of acute leukemias. Am.

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CYP2D6, NAT2 and CYP2EI genetic polymorphisms in nonagenarians

Cited by 40 publications

References 22 publications

Serum N-glycan profile shift during human ageing

Serum N-glycan profile shift during human ageing

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Role ofCYP2D6, CYP1A1, CYP2E1, GSTT1, andGSTM1 genes in the susceptibility to acute leukemias

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