Serum N-glycan profile shift during human ageing

Vanhooren, Valerie; Dewaele, Sylviane; Libert, Claude; Engelborghs, Sebastiaan; Deyn, Peter Paul De; Toussaint, Olivier; Debacq‐Chainiaux, Florence; Poulain, Michel; Glupczynski, Youri; Franceschi, Claudio; Jaspers, Koos; Pluijm, Ingrid van der; Hoeijmakers, Jan H.J.; Chen, Cuiying Chitty

doi:10.1016/j.exger.2010.08.009

Cited by 112 publications

(108 citation statements)

References 29 publications

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…In perfect congruence with this finding are recent data on N-glycosylation profiling of plasma in patients suffering from posttraumatic stress disorders (PTSD): Specific changes in the pattern of N-glycosylation had been shown to occur during aging and were proposed as a biomarker for physiological aging (Vanhooren et al, 2010). We could…”

Section: Molecular Consequences Of Psychological Stress and Agingsupporting

confidence: 64%

Molecular consequences of psychological stress in human aging

Moreno‐Villanueva

Bürkle

2015

Experimental Gerontology

View full text Add to dashboard Cite

Psychological stress has often been described as a feeling of being overwhelmed by the necessity of constant adjustment to an individual's changing environment. Stress affects people of all ages, but the lives of the elderly may particularly be affected. Major changes can cause anxiety leading to feelings of insecurity and/or loss of self-esteem and depression. The cellular mechanisms underlying psychological stress are poorly understood. This review focuses on the physical and molecular consequences of psychological stress linked to aging processes and, in particular, how molecular changes induced by psychological stress can compromise healthy aging.

show abstract

Section: Molecular Consequences Of Psychological Stress and Agingsupporting

confidence: 64%

Molecular consequences of psychological stress in human aging

Moreno‐Villanueva

Bürkle

2015

Experimental Gerontology

View full text Add to dashboard Cite

show abstract

“…IgG Fc glycosylation modulates inflammation (25,26) and through promotion or suppression of inflammation, it may significantly contribute to the process of biological aging (27–29). This hypothesis is further supported by the observed decrease in galactosylation in some premature ageing syndromes (13,30). …”

Section: Discussionmentioning

confidence: 59%

Glycans Are a Novel Biomarker of Chronological and Biological Ages

Krištić

Vučković

Menni

et al. 2013

The Journals of Gerontology: Series A

333

302

View full text Add to dashboard Cite

Fine structural details of glycans attached to the conserved N-glycosylation site significantly not only affect function of individual immunoglobulin G (IgG) molecules but also mediate inflammation at the systemic level. By analyzing IgG glycosylation in 5,117 individuals from four European populations, we have revealed very complex patterns of changes in IgG glycosylation with age. Several IgG glycans (including FA2B, FA2G2, and FA2BG2) changed considerably with age and the combination of these three glycans can explain up to 58% of variance in chronological age, significantly more than other markers of biological age like telomere lengths. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age. Thus, IgG glycosylation appears to be closely linked with both chronological and biological ages. Considering the important role of IgG glycans in inflammation, and because the observed changes with age promote inflammation, changes in IgG glycosylation also seem to represent a factor contributing to aging.Significance StatementGlycosylation is the key posttranslational mechanism that regulates function of immunoglobulins, with multiple systemic repercussions to the immune system. Our study of IgG glycosylation in 5,117 individuals from four European populations has revealed very extensive and complex changes in IgG glycosylation with age. The combined index composed of only three glycans explained up to 58% of variance in age, considerably more than other biomarkers of age like telomere lengths. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age; thus, IgG glycosylation appears to be closely linked with both chronological and biological ages. The ability to measure human biological aging using molecular profiling has practical applications for diverse fields such as disease prevention and treatment, or forensics.

show abstract

“…• Proteomic approaches can also play a pivotal role in investigating PTMs during ageing. For instance, glycosylation was shown to be involved in ageing, as high levels of N-glycans were shown to be significantly correlated with age (Vanhooren et al, 2010).…”

Section: Resultsmentioning

confidence: 99%