Molecular consequences of psychological stress in human aging

Moreno‐Villanueva, María; Bürkle, Alexander

doi:10.1016/j.exger.2014.12.003

Cited by 21 publications

(17 citation statements)

References 38 publications

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“…Results may, therefore, not be generalizable to younger populations or populations within a different HIV epidemic setting. Also, individuals with major depression were excluded from the study; as psychological stress has been linked with molecular changes that can affect the aging process [43], this could have resulted in an underestimation of age advancement in both COBRA groups. Finally, the age advancement observed in PLWH, COBRA HIV-negative individuals and blood donors is relative to the population used by the MARK-AGE project to develop the algorithm to estimate biological age.…”

Section: Discussionmentioning

confidence: 99%

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Francesco

Wit

Bürkle

et al. 2019

Aids

108

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Section: Discussionmentioning

confidence: 99%

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Francesco

Wit

Bürkle

et al. 2019

Aids

108

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“…The [19] in humans. In this regard, it can demonstrate many peripheral changes of aging from chronic stress, including the decrease in proteolytic clearance within peripheral cells [7], change in length of telomere [48], increase in DNA damage [48], alternation in immunological inflammation [48], and so on.…”

Section: Discussionmentioning

confidence: 99%

“…Obviously, the stress response is thus maintained in aging, which may cause decrease in proteolytic clearance within peripheral cells during aging [7]. Besides, it was recently reviewed that the psychological stress might lead to aging via many other molecular processes in cells, such as the change in length of telomere, increase in DNA damage, alternation in immunological inflammation, and so on [48].…”

Section: The Intact Hypothalamic Paraventricular Nucleus (Pvn) Duringmentioning

confidence: 99%

The Peripheral Hypotheses of Hypothalamic Aging

Cai¹

2018

OALib

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It is well known that the hypothalamic changes in control of hormones determine the chronological sequence of aging in mammals. For decades, it has been demonstrated in humans that the hypothalamic nuclei manifest heterogeneity in degeneration during aging, with the neuron number decreasing in both the suprachiasmatic nucleus (SCN) and the preoptic sexually dimorphic nucleus (SDN-POA) in the process of senescence, while the neuron number remains unchanged in the paraventricular nucleus (PVN). Recently, it was newly hypothesized some peripheral mechanisms responsible for the senescent changes of the hypothalamic nuclei. It was proposed by Cai that the decrease in slow-wave sleep (SWS) caused the degeneration of the suprachiasmatic nucleus (SCN). Besides, when reviewing the proposal by the European people in television about the senescent pathway for male reproduction on the degeneration of hypothalamic preoptic area by the common knowledge of reduction of sperm production from adipose accumulation in the middle/old age, it was as well demonstrated that the reduced testosterone level from the increased body fat caused the degeneration of the male preoptic sexually dimorphic nucleus (SDN-POA). It seems both the activity-dependent and hormonal regulation of the neuronal numbers are involved in the mechanisms causing the senescence of the hypothalamic nuclei. It is further pointed out that the paraventricular nucleus (PVN) maintaining its neuronal number unchanged in aging may cause many cellular and molecular changes of aging from chronic stress. It is expected that these preliminary considerations could elicit more investigations on the other peripheral causes for the hypothalamic aging, such as the cholesterol, hypertension, and so on.

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“…The level of biological processes affected by PS depends on its duration [14]. Short-lasting PS activates the sympathetic nervous system (SNS) secreting catecholamines (CATs), which may exert beneficial effects [15]. In contrast, long-lasting persistent PS or high levels of PS are accompanied by biological, psychological, and behavioral changes and may have adverse consequences on health.…”

Section: Introductionmentioning

confidence: 99%

Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis

Kruk

Aboul‐Enein

Bernstein

et al. 2019

Oxidative Medicine and Cellular Longevity

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Background Epidemiological evidence continues to accumulate on the effect of psychosocial and behavioral factors in relation to cancer risk, progression, and mortality. Material and Methods This article presents the current evidence on the relationship between psychological stress and the risk of cancer and cellular aging process. Ten databases were searched to identify publications up to September 2019. References from retrieved articles were also reviewed. We included nine review papers and 26 cohort or case-control studies based on inclusion/exclusion criteria. Results Results of previously published review articles did not show consistent evidence for the association between cancer risk and psychological stress, while previous evidence is stronger regarding the role of chronic psychological stress on cancer growth and metastasis and aging. In seven observational studies, severe life events, anxiety, depression, insufficient social support perception, or avoiding coping strategy were significantly associated with breast cancer risk. For other specific types of cancer, 11 studies reported increased risk factors for stressful life events, and two others found increased mortality or a decline in treatment adherence. Conclusions Recent epidemiological evidence generally suggests psychosocial factors may be considered risk factors for specific types of cancer and play a key role in the cellular aging process. Understanding molecular mechanisms of the stress interaction is important in cancer management and prevention. The psychological stressors should be considered when developing or evaluating change in psychosocial practice.

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Molecular consequences of psychological stress in human aging

Cited by 21 publications

References 38 publications

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

The Peripheral Hypotheses of Hypothalamic Aging

Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis

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