Dalbergia odorifera Extract Ameliorates UVB‐Induced Wrinkle Formation by Modulating Expression of Extracellular Matrix Proteins

Abstract

Preclinical Research Emerging evidence suggests that Dalbergia odorifera T. Chen (Leguminosae), an indigenous medicinal herb, has therapeutic potential. This study examined the antiwrinkle effects of ethanol extracts of D. odorifera in UVB-irradiated human skin cells. Ethanol extracts of D. odorifera and thier constituents, dalbergin and sativanone, induced expression of collagen type I and transforming growth factor (TGF)-β1 in human dermal fibroblasts. In HR-1 hairless mice exposed to UVB, the ethanol extract reduced wrinkle formation and skin thickness. This inhibitory effect of ethanol extract was associated with the restoration of collagen type I, TGF-β1, and elastin to levels approaching those in skin tissues not exposed to UVB, which was accompanied by the reduction of matrix metalloproteinase-2 and upregulation of tissue inhibitors of metalloproteinase (TIMP)-2 and TIMP-3 in skin tissue exposed to UVB. These results suggest that the ethanol extracts prevent some effects of photoaging and maintain skin integrity by regulating the degradation of the extracellular matrix proteins. © 2015 Wiley Periodicals, Inc.

Skin-Whitening and Antiwrinkle Proprieties of Maackia amurensis Methanolic Extract Lead Compounds

“…Wrinkles appear on the skin owing to the loss of elast dation of collagen in the dermis [33,34]. Many studies hav wrinkles increase and soluble collagen decreases in mouse amined whether M. amurensis branch extract affects collag sible for the antiwrinkle effect.…”

“…Wrinkles appear on the skin owing to the loss of elasticity resulting from the degradation of collagen in the dermis [33,34]. Many studies have been reported that with age, wrinkles increase and soluble collagen decreases in mouse and human skin [35].…”

A Review on the Medicinal Plant Dalbergia odorifera Species: Phytochemistry and Biological Activity

“…Studying herbal cosmetics for preventing skin photoaging, 40, 60, 80, or 100% ethanol extracts of Korean medicinal plant D. odorifera heartwood and their constituents sativanone (35) and dalbergin (53) exerted an increased expression of type I collagen in human dermal fibroblasts with increasing doses from 0.1 to 10 μ g/mL, especially in terms of 60% ethanol extract [ 52 ]. As a consequence, 60% ethanol extract was further assessed to examine the effects on the expression of other extracellular matrix (ECM) related proteins in human dermal fibroblasts, in which this and its constituents 35 (1 μ g/mL) and 53 (10 μ g/mL) elevated the levels of type I collagen, elastin, and transforming growth factor- β 1 (TGF- β 1) for 38 h treatment.…”