<i>Daphne mucronata</i>-mediated phytosynthesis of silver nanoparticles and their novel biological applications, compatibility and toxicity studies

Shah, Asma Tufail; Lutfullah, Ghosia; Ahmad, Kafeel; Khalil, Ali Talha; Mâaza, M.

doi:10.1080/17518253.2018.1502365

Cited by 60 publications

(26 citation statements)

References 46 publications

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“…Previously optimized protocol was used to study the in vitro cytotoxic potential of bioinspired NiONPs against HepG2 cancer cell line. Cells were grown on DMEM media added with 10% FBS, 1% penicillin and 1% streptomycin.…”

Section: Experimental Methodsmentioning

confidence: 99%

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Iqbal

Abbasi

Mahmood

et al. 2019

Applied Organom Chemis

145

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In the present report, Nickel oxide nanoparticles (NiONPs) were synthesized using Rhamnus virgata (Roxb.) (Family: Rhamnaceae) as a potential stabilizing, reducing and chelating agent. The formation, morphology, structure and other physicochemical properties of resulting NiONPs were characterized by Ultra violet spectroscopy, X-ray diffraction (XRD), Fourier Transform Infrared analysis (FTIR), Scanning electron microscopy (SEM), Energy-dispersivespectroscopy (EDS), Transmission electron microscopy (TEM), Raman spectroscopy and dynamic light scattering (DLS). Detailed in vitro biological activities revealed significant therapeutic potential for NiONPs. The antimicrobial efficacy of biogenic NiONPs was demonstrated against five different gram positive and gram negative bacterial strains. Klebsiella pneumoniae and Pseudomonas aeruginosa (MIC: 125 μg/mL) were found to be the least susceptible and Bacillus subtilis (MIC: 31.25 μg/mL) was found to be the most susceptible strain to NiONPs. Biogenic NiONPs were reported to be highly potent against HepG2 cells (IC 50 : 29.68 μg/ml). Moderate antileishmanial activity against Leishmania tropica (KMH 23 ) promastigotes (IC 50 : 10.62 μg/ml) and amastigotes (IC 50 : 27.58 μg/ml) cultures are reported. The cytotoxic activity was studied using brine shrimps and their IC 50 value was recorded as 43.73 μg/ml. For toxicological assessment, NiONPs were found compatible towards human RBCs (IC 50 : > 200 μg/ml) and macrophages (IC 50 : > 200 μg/ml), deeming particles safe for various applications in nanomedicines. Moderate antioxidant activities: total antioxidant capacity (TAC) (51.43%), 2,2-diphenyl-1-picrylhydrazyl (DPPH) activity (70.36%) and total reducing power (TRP) (45%) are reported for NiONPs. In addition, protein kinase and alpha amylase inhibition assays were also performed. Our results concluded that Rhamnus virgata synthesized NiONPs could find important biomedical applications with low cytotoxicity to normal cells.

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Section: Experimental Methodsmentioning

confidence: 99%

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Iqbal

Abbasi

Mahmood

et al. 2019

Applied Organom Chemis

145

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“…Most stable nanoparticles are being synthesized using gold, silver, and copper metals, which are useful in different areas e.g. biological labeling, photography, photonics, surface-enhanced Raman scattering detections, and optoelectronics (5)(6)(7). Environmentally benign and commercially viable procedures are required to synthesize highly stabilized metal nanoparticles particularly silver nanoparticles (AgNPs).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, "green nano-synthesis" has been preferred over chemical methods and is considered as an environment-friendly alternative. Green syntheses use environmentally benign aqueous solvents at biological pH and offer better manipulation, control over crystal growth and their stabilization due to slower kinetics (7,8).…”

Section: Introductionmentioning

confidence: 99%

Pinus wallichiana-synthesized silver nanoparticles as biomedical agents: in-vitro and in-vivo approach

Khan

Nadhman

et al. 2020

Green Chemistry Letters and Reviews

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The current study aims to assess the aqueous extract of Pinus wallichiana stem for the synthesis of small spherical-shaped (10-30 nm) silver nanoparticles (AgNPs) and their in-vitro and in-vivo biomedical applications. The biosynthesized AgNPs were nonmutagenic and safe at all test doses as per Ames and acute toxicity assay (20, 40, 60, and 80 mg/kg). The percent writhing inhibitory effect generated by AgNPs was 42.51, 50.84, and 59.06 at test doses of 10, 20, and 30 mg/kg, respectively. The percent decreased in gastrointestinal tract motility observed was 41.34%, 32.69%, and 28.48% at 10, 20, and 30 mg/kg, respectively. They also showed a significant antipyretic effect after 1, 2, and 3 h in comparison to normal saline. The AgNPs of P. wallichiana showed good antibacterial activity against Acinetobacter baumannii (60% with MIC 50 = 2.36 mg/ ml and MBC = 5.0 mg/ml). These nanoparticles also possessed good antioxidant activity of 61.77 ± 0.828% and 70.25 ± 0.56% at 400 and 500 µg/ml, respectively and lack phytoagglutinin potential. Because of their high potency as biomedical agents, these nanoparticles can be a good alternative to the currently available drugs and approaches.

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“…Metal and plant frameworks have emerged as an exciting interface to synthesize nanoparticles (NPs) having diverse properties . While biosynthesis of gold and silver NPs remains a primary focus area for scientists, the green synthesis methods are now extended to various nano‐scaled multi‐functional metal oxides having diverse applications . Recently, we demonstrated biosynthesis and potential biomedical applications of metal oxide NPs like ZnO, NiO, Fe 2 O 3 and Co 3 O 4.…”

Section: Introductionmentioning

confidence: 99%

Physiochemical properties and novel biological applications of Callistemon viminalis‐mediated α‐Cr₂O₃ nanoparticles

Hassan

Khalil

Solangi

et al. 2019

Applied Organom Chemis

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We report an eco-friendly synthesis of α-Cr 2 O 3 nanoparticles (NPs) using Callistemon viminalis (Bottle Brush) flower extracts as an efficient reducing and capping agent. NPs of sizes 15 nm and 17 nm were synthesized by annealing them at 400°C and 500°C, respectively, which were characterized by X-ray diffraction, UV-Vis, Fourier transform-infrared, high-resolution-transmission electron microscopy/scanning electron microscopy, SAED, energy-dispersive X-ray spectroscopy and SQUID. Microplate-based assay was used for examining antibacterial potential against 12 pathogenic bacterial strains, and their minimum inhibitory concentrations were calculated. MTT cytotoxic assay was accomplished on Leishmania tropica amastigotes and promastigotes, which revealed IC 50 values of 44 μg/ml and 10.56 μg/ml, respectively. An IC 50 value of 46.32 μg/ml was obtained for HepG2 cancer cells. Enzyme inhibition studies indicated good acetylcholinesterase, moderate butyrylcholinesterase and low alpha-glucosidase inhibition. Hemolytic assay indicated hemocompatibility at low concentration. In addition, good DPPH radical scavenging and moderate reducing power and total antioxidant potential was revealed by α-Cr 2 O 3 NPs.

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Daphne mucronata-mediated phytosynthesis of silver nanoparticles and their novel biological applications, compatibility and toxicity studies

Abstract: View related articles View Crossmark data Citing articles: 1 View citing articles Daphne mucronata-mediated phytosynthesis of silver nanoparticles and their novel biological applications, compatibility and toxicity studies

Cited by 60 publications

References 46 publications

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Pinus wallichiana-synthesized silver nanoparticles as biomedical agents: in-vitro and in-vivo approach

Physiochemical properties and novel biological applications of Callistemon viminalis‐mediated α‐Cr₂O₃ nanoparticles

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Daphne mucronata-mediated phytosynthesis of silver nanoparticles and their novel biological applications, compatibility and toxicity studies

Abstract: View related articles View Crossmark data Citing articles: 1 View citing articles Daphne mucronata-mediated phytosynthesis of silver nanoparticles and their novel biological applications, compatibility and toxicity studies

Cited by 60 publications

References 46 publications

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications

Pinus wallichiana-synthesized silver nanoparticles as biomedical agents: in-vitro and in-vivo approach

Physiochemical properties and novel biological applications of Callistemon viminalis‐mediated α‐Cr2O3 nanoparticles

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Physiochemical properties and novel biological applications of Callistemon viminalis‐mediated α‐Cr₂O₃ nanoparticles