2012
DOI: 10.1093/eurjhf/hfr152
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DHRS7c, a novel cardiomyocyte‐expressed gene that is down‐regulated by adrenergic stimulation and in heart failure

Abstract: AimsAlthough cardiac diseases account for the highest mortality and morbidity rates in Western society, there is still a considerable gap in our knowledge of genes that contribute to cardiac (dys)function. Here we screened for gene expression profiles correlated to heart failure. Methods and resultsBy expression profiling we identified a novel gene, termed DHRS7c, which was significantly down-regulated by adrenergic stimulation and in heart failure models. Dhrs7c is a short chain dehydrogenase/reductase (SDR) … Show more

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Cited by 26 publications
(21 citation statements)
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“…We have also tested a number of other genes identified in our previous screen [19], like Dhrs7c [28], but none of these induced hypertrophy, suggesting specificity. Several hypertrophic signaling pathways were analyzed, but only the Akt pathway, which has a general function in cell survival and growth [29,30], was activated by AKIP1.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We have also tested a number of other genes identified in our previous screen [19], like Dhrs7c [28], but none of these induced hypertrophy, suggesting specificity. Several hypertrophic signaling pathways were analyzed, but only the Akt pathway, which has a general function in cell survival and growth [29,30], was activated by AKIP1.…”
Section: Discussionmentioning
confidence: 99%
“…The annealed primers were cloned into a pENTR4 vector containing a H1-promoter and a GFP marker gene. Recombinant adenovirus was generated as previously described [28]. For control infections a corresponding GFP expressing adenovirus was used.…”
Section: Methodsmentioning
confidence: 99%
“…The annealed primers were cloned into a pENTR4 vector containing a H1-promoter and a GFP marker gene. Recombinant adenovirus was generated as previously described (13). For adenoviral infections, neonatal ventricular cardiomyocytes were infected with an MOI of 50.…”
Section: Methodsmentioning
confidence: 99%
“…DHRS7C is identified as an integral protein immersed into the membrane of the sarcoplasmic reticulum which is likely to catalyze the NAD + -dependent conversion of all-trans-retinol to all-trans-retinal [23]. Therefore, this enzyme may be implicated in retinoic acid signalling [24].…”
Section: Bioinformatics Analysismentioning
confidence: 99%