DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: Association and interaction study

Abstract

The TaqI-A of the ANKK1 gene and the C957T of the DRD2 gene are epistatically associated with psychopathic traits in alcohol-dependent patients.

The ANKK1/DRD2 locus is a genomic substrate for affective priming and recognition of angry faces

“…2008). In agreement with our results, research works involving fear‐potentiated startle have demonstrated that individuals high in psychopathy are less affected by peripheral information which competes with goal‐relevant information (Newman et al.…”

“…Genotyping of ANKK1 Taq IA and DRD2 C957T SNPs was performed as described previously (Ponce et al. 2008). The resulting genotypes for Taq IA were clustered according to the presence of at least one A1 allele (A1+ genotype: heterozygous; A1− genotype: homozygous for the A2 allele).…”

“…A low degree of Taq IA‐to‐C957T LD (linkage disequilibrium) has been previously found in the Spanish population ( D ′: 0.58, r 2 : 0.14) (Ponce et al. 2008). …”

“…(2008) found an epistatic effect of Taq IA and C957T SNPs on the expression of psychopathic traits. Psychopathy has been associated, in turn, with alterations in some affective processes where the dopaminergic system plays a key role, such as affective priming (Blair et al.…”

Pharmacogenetics - A Treatment Strategy for Alcoholism

“…Ponce et al (2008) reported that the two SNPs (-141C Ins/Del) and TaqI A, present on DRD2 gene locus were associated with alcoholism in North Indian population. Studies from South Indian population have reported no association between TaqI A polymorphism and alcoholism.…”