2013
DOI: 10.1152/ajpcell.00012.2013
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Dueling nucleosides: cross-regulation of extracellular adenosine by guanosine. Focus on “Extracellular guanosine regulates extracellular adenosine levels”

Abstract: IN ADDITION TO SERVING as components of nucleic acids and central players in intracellular energy metabolism, adenosineand guanosine-based metabolites play critical but distinct roles in signal transduction processes. ATP has two major functions in intracellular signaling. It serves as the principal nucleotide phosphate donor for the myriad protein kinases that act as molecular switches for most critical intracellular functions. In addition, ATP is the substrate for adenylyl cyclases and inositol lipid kinases… Show more

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Cited by 4 publications
(4 citation statements)
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“…This finding suggests that GBP1 may participate in the regulation of the balance of extracellular guanosine nucleotides in the EOC extracellular environment, through its GTPase activity. Previous observations suggested that extracellular guanosine regulates extracellular adenosine levels [49] and may, therefore, modulate purinergic signaling pathways [50].…”
Section: Discussionmentioning
confidence: 99%
“…This finding suggests that GBP1 may participate in the regulation of the balance of extracellular guanosine nucleotides in the EOC extracellular environment, through its GTPase activity. Previous observations suggested that extracellular guanosine regulates extracellular adenosine levels [49] and may, therefore, modulate purinergic signaling pathways [50].…”
Section: Discussionmentioning
confidence: 99%
“…In this context, nucleosides and nucleotides represent an attractive category of molecules for conjugation to drugs, due to the presence of complex systems of protein transporters on cellular membranes that can recognize and internalize them . Furthermore, considering that many nucleosides and nucleotides are effective drugs against viral diseases and cancers, as well as playing key roles in the regulation of cellular processes and in signal transduction, their conjugation to a reactive platinum unit could produce molecules with interesting biological properties. Despite this potential, only a few examples of molecules containing platinum and nucleoside moieties have been described in the literature .…”
Section: Introductionmentioning
confidence: 99%
“…[11][12][13][14][15][16][17][18] Furthermore, thanks to the synergistic effect that may result, tethering between biologically active molecules and platinum units could afford novel complexes with improved drug-targeting and drug-delivery properties. [19][20][21][22] known to inhibit the growth of several cancer lines [23][24][25][26] and many of them are clinically used as antiviral drugs. [19][20][21][22] known to inhibit the growth of several cancer lines [23][24][25][26] and many of them are clinically used as antiviral drugs.…”
Section: Introductionmentioning
confidence: 99%
“…[12] Nucleosides and nucleotides (NNs) and their analogues play a key role in the regulation of cellular processes and in signal transduction. [19][20][21][22] known to inhibit the growth of several cancer lines [23][24][25][26] and many of them are clinically used as antiviral drugs. [27][28][29] Despite this, only a few platinum complexes carrying nucleoside scaffolds have been proposed.…”
Section: Introductionmentioning
confidence: 99%