<i>Escherichia coli</i> of human origin binds to carcinoembryonic antigen (CEA) and non‐specific crossreacting antigen (NCA)

Leusch, Hans-Georg; Hefta, Stanley A.; Drzeniek, Zofia; Hummel, Klaus M.; Markos-Pusztai, Zsuzanna; Wagener, Christoph

doi:10.1016/0014-5793(90)80603-g

Cited by 74 publications

(46 citation statements)

References 23 publications

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“…Several glycosylated receptors for type 1 pili have been documented, such as glycosylphosphatidylinositol-anchored (GPI-anchored) protein CD48, Tamm-Horsfall protein (THP), and various family members of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) (16)(17)(18)(19)(20). Western blot analysis of total protein extract from ileal specimens of 9 CD patients, taken in both involved and uninvolved areas, and of 9 controls showed a strong expression of CEACAM5 (also called CEA or CD66e) and CEACAM6 (also called CD66c or non-crossreacting antigen [NCA]) in the ileal mucosa of CD patients in both involved and uninvolved areas ( Figure 3A).…”

Section: Introductionmentioning

confidence: 99%

CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

Barnich¹,

Carvalho²,

Glasser³

et al. 2007

J. Clin. Invest.

511

473

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The ileal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC) that are able to adhere to and invade intestinal epithelial cells. Here, we show that CD-associated AIEC strains adhere to the brush border of primary ileal enterocytes isolated from CD patients but not controls without inflammatory bowel disease. AIEC adhesion is dependent on type 1 pili expression on the bacterial surface and on carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) expression on the apical surface of ileal epithelial cells. We report also that CEACAM6 acts as a receptor for AIEC adhesion and is abnormally expressed by ileal epithelial cells in CD patients. In addition, our in vitro studies show that there is increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-γ or TNF-α stimulation and after infection with AIEC bacteria, indicating that AIEC can promote its own colonization in CD patients.

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Section: Introductionmentioning

confidence: 99%

CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

Barnich¹,

Carvalho²,

Glasser³

et al. 2007

J. Clin. Invest.

511

473

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“…39 CEA, as well as BGP-I, reportedly bind and thelial cells, particularly dysplasia, which is frequent in hepatolithiasis. 2,40 Approximately 10% of patients agglutinate bacterial pathogens such as Escherichia coli 19,20 and may thereby play a role in localizing and with hepatolithiasis have complicating cholangiocarcinoma, 2,40 and dysplasia is considered to be a preneomaintaining bacterial infection. In hepatolithiasis, it is generally accepted that E. coli and other bacteria of plastic lesion in such cases.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…a tumor marker, 16 also functions as an intercellular Sialyl-Tn antigen in biliary mucinous glycoprotein will adhesion molecule 17,18 and also binds and aggregates be a good marker of biliary and pancreatic carcinoma, bacteria. 19,20 Immunohistochemical studies [21][22][23] have and probably for cholangiocarcinoma complicated with disclosed that the biliary epithelial cells at different anatomic levels have a characteristic distribution of carbohydrate antigens, and their altered distribution Hepatolithiasis is quite common in the Far East, in-is associated with biliary tract diseases. It is therefore cluding Japan, although it is extremely rare in Western likely that alterations of the carbohydrate residues of countries.…”

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confidence: 99%

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Carcinoembryonic antigen and blood group-related carbohydrate antigens in glycoproteins in human bile in hepatolithiasi

Sasaki

1996

Hepatology

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We investigated whether carbohydrate antigens on cholangitis, 2,4 in which the proliferated peribiliary biliary glycoproteins and carcinoembryonic antigen glands secrete large amounts of acid (sialylated and (CEA) are related to hepatolithiasis. CEA, ABO, and sulfated) or neutral mucin into the biliary lumen. 4 Most Lewis blood group-related antigens, as well as sialyl-intrahepatic calculi consist of calcium-bilirubinate Tn antigen in hepatic bile, were analyzed by Western (brown pigment) stones. 4,5 Bacterial infection, bile stablotting in samples from 12 patients with hepatolithiasis sis, and an alteration of the bile composition are and 37 with other biliary diseases (choledocholithiasis, thought to be responsible for the nucleation, formation, 13; cholecystolithiasis, 5; acute cholecystitis, 2; chol-and maturation of intrahepatic calculi. 6,7 In addition, angiocarcinoma, 5; common bile duct carcinoma, 4; panthe increased mucin production and secretion from the creatic carcinoma, 6; and metastatic carcinoma of liver, bile ducts may play an important role in the develop-2). CEA was positive on mucinous glycoprotein in six patients (50%) with hepatolithiasis and one case (17%) ment of intrahepatic calculi. 4,5,8 Biliary mucin, particuwith pancreatic carcinoma. CEA was also positive on a larly sulfated, reportedly promotes the formation of calglycoprotein of approximately 200 kd in eight patients cium-bilirubinate stones. 4,7 Histochemically, these (67%) with hepatolithiasis and two (33%) with pancreatic stones are composed of alternating multilayers of mucarcinoma. Lewis X was detected on the mucinous glyco-cin and pigment (calcium-bilirubinate) on their cut surprotein in almost all samples, as well as on glycoproteins face, suggesting that mucin bridges the pigment layers of approximately 180 kd in all hepatolithiasis samples and participates in the precipitation of calcium-biliruand approximately half of those from patients with other binate. and proteoglycans play an important role in cell-to-(50%) with common bile duct carcinoma, and all pancreatic carcinoma samples. Mucinous glycoprotein and gly-cell adhesion and recognition 10-13 and also have a close coproteins containing CEA and Lewis X antigens are en-relationship with a specific bacterial infection.14,15 Carriched in hepatic bile of hepatolithiasis, and they may be cinoembryonic antigen (CEA), which is widely used as closely related to the formation of intrahepatic calculi. a tumor marker, 16 also functions as an intercellular Sialyl-Tn antigen in biliary mucinous glycoprotein will adhesion molecule 17,18 and also binds and aggregates be a good marker of biliary and pancreatic carcinoma, bacteria. 19,20 Immunohistochemical studies 21-23 have and probably for cholangiocarcinoma complicated with disclosed that the biliary epithelial cells at different hepatolithiasis. (HEPATOLOGY 1996;23:258-263.) anatomic levels have a characteristic distribution of carbohydrate antigens, and their altered distribution Hepatolithiasis is quite common in the Fa...

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“…Those (1998) 77(5), [683][684][685][686][687][688][689][690][691][692][693] O"I Cancer Research Campalgn 1998 inflammation (Leusch et al, 1990). As a result, the regular luminal shedding of CEA may serve to control luminal bacterial load and translocation across the gut.…”

Section: Mechanisms Of Tumour Escape From Immunological Recognitionmentioning

confidence: 99%

Biological therapy: approaches in colorectal cancer

Zbar

Lemoine²,

Wadhwa³

et al. 1998

Br J Cancer

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Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non‐specific crossreacting antigen (NCA)

Cited by 74 publications

References 23 publications

CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease

Carcinoembryonic antigen and blood group-related carbohydrate antigens in glycoproteins in human bile in hepatolithiasi

Biological therapy: approaches in colorectal cancer

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