<i>Ex vivo</i> anti-inflammatory effects of probiotics for periodontal health

Schmitter, Tim; Fiebich, Bernd L.; Fischer, Joerg T; Gajfulin, Max; Larsson, Niklas; Rose, Thorsten; Goetz, Marcus R.

doi:10.1080/20002297.2018.1502027

Cited by 33 publications

(24 citation statements)

References 25 publications

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“…The model used is well established for testing anti‐inflammatory effects of compounds as it examines various inflammatory mediators. 58 , 59 Parameters such as PGE2 and IL‐1 are known to play a crucial role in gingivitis. The in vitro results showed that the tested extracts potently prevented both PGE2 and IL‐1 release.…”

Section: Discussionmentioning

confidence: 99%

Do natural ingredients in a dentifrice contribute to prevention of plaque and gingivitis?

Valkenburg

Rosema

Hennequin-Hoenderdos

et al. 2021

Int J Dental Hygiene

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Objective: To test the effectiveness of a dentifrice containing the turmeric and licorice extract compared to a control for preventing plaque and gingivitis over a fourmonth period.Material and methods: Ninety (non-dental) participants with moderate gingival inflammation (≥ 40%) were selected. The triple blind study consisted of two phases, namely at first a 3-week pre-experimental phase of using an oxygenating and chlorhexidine (CHX) mouthrinse. Secondly, a 4-month experimental period in which participants were randomly assigned to a test or control group. All were instructed to brush their teeth twice daily for 2 minutes with their assigned dentifrice. Gingival bleeding (BI), plaque (PI) and gingivitis (GI) were assessed.Results: Eighty participants completed the protocol. At the first assessment in the pre-experimental phase, the mean scores of all indices showed no differences for the two groups. At the second session, the values of all three parameters had decreased significantly (p < 0.001). At the last session, the BI values were 0.52(0.25) for the test group and 0.56(0.25) for the control, the mean GI was 0.27(0.17) for the test group and 0.31(0.16) for the control, and for PI the scores were 1.89(0.46) for the test group and 1.98(0.43) for the control group. Statistical comparison of the scores for the two groups at each stage of the study showed no significant difference for any of the parameters. Conclusion:Within the limits of the current study design, dentifrice formulation and concentration of turmeric/licorice extracts, the results show that the adjuvant effect of the natural ingredients in the test dentifrice was not evident on clinical parameters of gingivitis and plaque.

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Section: Discussionmentioning

confidence: 99%

Do natural ingredients in a dentifrice contribute to prevention of plaque and gingivitis?

Valkenburg

Rosema

Hennequin-Hoenderdos

et al. 2021

Int J Dental Hygiene

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“…The probiotics have been shown to possess anti-inflammatory and immune-modulatory properties (Akour, 2020;Khaneghah et al, 2020). Mounting shreds of evidence from several in vitro studies suggest that the active anti-inflammatory role of probiotics by suppression of pro-inflammatory cytokine expression and reduction in the release of inflammatory mediators (Schmitter et al, 2018;Yu et al, 2019).…”

Section: Nutraceutical Approaches For Attenuation Of Inflammatory Responses Probioticsmentioning

confidence: 99%

Could Nutraceutical Approaches Possibly Attenuate the Cytokine Storm in COVID-19 Patients?

Vignesh

Velu

Sureban

2021

Front. Cell. Infect. Microbiol.

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“…development of gingivitis and stimulates an inflammatory response in host cells. 37 The mechanism by which these strains can inhibit the LPS-stimulated release of inflammatory mediators from host cells has not been revealed and warrants investigation in future studies. However, previous research showed that probiotic strains used in the gut can interact with toll-like receptors on host cells to downregulate the expression of nuclear factor-kappa-B and proinflammatory cytokines.…”

Section: Synbiotic and Periodontal Indicesmentioning

confidence: 99%

<p>The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial</p>

Bazyar¹,

Maghsoumi‐Norouzabad²,

Yarahmadi³

et al. 2020

DMSO

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The aim of the current study was to investigate that combination of the synbiotic supplementation in adjunct with non-surgical periodontal therapy (NSPT) is useful in treating periodontitis and biomarkers of oxidative stress in type 2 diabetes mellitus (T2DM) patients. Methods: In this study, 47 patients suffering from DM and CP were recruited and randomly assigned to two groups. The intervention (n= 23) and control (n=24) groups received either multispecies probiotic supplement plus 100 mg fructo-oligosaccharide (500 mg in each capsule) or placebo capsule containing 500 mg wheat flour, respectively, every day for 8 weeks. All subjects were treated with NSPT during the intervention period. Serum levels of interleukin-1β (IL-1β), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and periodontal indices including clinical attachment loss (CAL), pocket depth (PD) (main outcome), BOP, and plaque index were measured before and after the intervention. Results: Supplementation with the synbiotic with NSPT led to a significant decrease in the levels of IL-1β, MDA, plaque index, PD, and CAL in the intervention group post-intervention (p < 0.05). The serum levels of TAC, SOD, and GPx were significantly increased in the intervention group compared with the baseline (p < 0.05). Consumption of synbiotic with NSPT, compared to the control, resulted in a significant decrease in the mean changes of IL-1β, MDA, and CAL (p < 0.05). Also, the mean changes of TAC and GPx were significantly higher in the intervention group compared with the control group (p < 0.05). Also, in the intervention group was seen a significant reduction in plaque index (p = 0.035) and BOP (p = 0.04) compared with the control group. Conclusion: It was observed that synbiotic supplementation with NSPT may be beneficial in improving inflammatory, antioxidant, and periodontal status in T2DM patients with CP.

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Ex vivo anti-inflammatory effects of probiotics for periodontal health

Cited by 33 publications

References 25 publications

Do natural ingredients in a dentifrice contribute to prevention of plaque and gingivitis?

Do natural ingredients in a dentifrice contribute to prevention of plaque and gingivitis?

Could Nutraceutical Approaches Possibly Attenuate the Cytokine Storm in COVID-19 Patients?

<p>The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial</p>

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