FEN1gene variants confer reduced risk of breast cancer in chinese women: A case-control study

Abstract

This study aimed to assess the associations of two common Flap endonuclease 1 (FEN1) polymorphisms (rs4246215 and rs174538) with breast cancer risk in northwest Chinese women. We conducted a case-control study with 560 breast cancer patients and 583 age-matched healthy controls from Northwest China. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to estimate the associations. We found a significantly reduced risk of breast cancer associated with T allele of rs4246215 (allele model: OR 0.81, 95% CI 0.68–0.96; homozygote model: OR = 0.59, 95% CI = 0.40–0.87; recessive model: OR = 0.61, 95% CI = 0.42–0.89), especially in postmenopausal women (OR = 0.58, 95% CI = 0.35–0.97). Furthermore, the polymorphism showed a decreased association with larger tumor size (heterozygote model: OR = 0.63, 95% CI = 0.44–0.92; dominant model: OR = 0.63, 95% CI = 0.44–0.90). For rs174538, we did not find any difference in all genetic models. However, rs174538 was associated with lymph node metastasis (heterozygote model: OR = 0.57, 95% CI = 0.39–0.81; dominant model: OR = 0.61, 95% CI = 0.43–0.86) and estrogen receptor status (heterozygote model: OR = 1.50, 95% CI = 1.05–2.15; dominant model: OR = 1.42, 95% CI = 1.01–1.98). Haplotype analysis showed that Trs4246215Grs174538 haplotype was a protective factor of breast cancer (OR = 0.34, 95% CI = 0.14–0.81). Our results suggest that FEN1 polymorphisms may reduce the risk of breast cancer in Chinese women.

Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study

“…We then assessed the DNA concentrations by spectrophotometry (DU530 UV/VIS spectrophotometer, Beckman Instruments, Fullerton, CA). The Multiplexed SNP Mass EXTEND assay was designed by Sequenom Mass‐ARRAY Assay Design (version3.0, Agena Bioscience, San Diego, CA), according to previous studies . Sequenom Mass‐ARRAY RS1000 and Sequenom Typer 4.0 software were used to genotype the SNPs and for the data analyses .…”

“…The Multiplexed SNP Mass EXTEND assay was designed by Sequenom Mass-ARRAY Assay Design (version3.0, Agena Bioscience, San Diego, CA), according to previous studies. [27][28][29][30] Sequenom Mass-ARRAY RS1000 and Sequenom Typer 4.0 software were used to genotype the SNPs and for the data analyses. 31 The primers of each SNP are presented in Table S1.…”

<em>CYP17 </em>polymorphisms are associated with decreased risk of breast cancer in Chinese Han women: a case&ndash;control study

“…The clinical and demographic characteristic of BC patients and controls were described in our previous studies. 25 , 26 The cases and controls were matched by age (Student’s t -test, P =0.612). As shown in Table 1 , there was no significant difference in the distribution of menopausal state between the two groups (χ 2 test, P =0.716).…”

Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility

“…Association study with 1840 lung cancer patients and 1958 controls further revealed that these two FEN1 SNPs conferred genetic susceptibility to lung cancer [ 49 ]. Moreover, some evidence was further observed to consolidate the contribution of the rs174538 and rs4246215 to the risk of different types of cancer [ 25 , 36 , 37 , 39 ]. Especially, these two SNPs were shown to decrease breast cancer risk in Chinese [ 25 ]and Iran [ 37 ] populations.…”

“…Moreover, some evidence was further observed to consolidate the contribution of the rs174538 and rs4246215 to the risk of different types of cancer [ 25 , 36 , 37 , 39 ]. Especially, these two SNPs were shown to decrease breast cancer risk in Chinese [ 25 ]and Iran [ 37 ] populations. The prevalence of the studied SNPs varies among different ethnic groups (data not shown).…”