Impact of four lncRNA polymorphisms (rs2151280, rs7763881, rs1136410, and rs3787016) on glioma risk and prognosis: A case‐control study

Abstract

Long noncoding RNA (lncRNA) polymorphisms are reportedly in connection with tumor susceptibility and prognosis. Glioma is one of the most aggressive and common cancers of the central nervous system. This study aimed to investigate the relationship between four lncRNA variants and glioma susceptibility and prognosis in a Chinese Han population. Sequenom Mass‐ARRAY was used to genotype 605 patients with glioma and 1300 cancer‐free individuals. Odds ratios or hazard ratios and related 95% confidence intervals were calculated to estimate the correlations. Logistic and Cox regression models, log‐rank tests, and Kaplan‐Meier curves were used for the statistical analysis. Six inheritance models showed that ANRIL rs2151280 variant genotype (A>G) was related to the susceptibility of glioma, while the other three lncRNAs showed no association. Patients treated with temozolomide or nimustine had better progression‐free survival (PFS) and overall survival (OS) than those treated with platinum. Besides, patients aged older than 40 years showed a poorer OS. The Cox multivariate analysis revealed that the rs1136410 GG genotype (A>G) was beneficial for OS and PFS. The Kaplan‐Meier analyses indicated that rs1136410 A>G and the rs7763881 A>C were associated with longer OS. ANRIL rs2151280 variant genotype might increase susceptibility of glioma. In addition, PARP1 rs1136410 variant genotype could be beneficial for the overall survival of patients with glioma. More research data are needed to further validate our results.

The POLR2E rs3787016 polymorphism is associated with susceptibility to and prognosis of gastric cancer

“…but not for lung cancer, liver cancer, and glioma [17,22].Our results demonstrated that the genotype AA of rs3787016 is significantly associated with increased gastric cancer risk, which is consistent with the findings of most of the related previous studies. Interestingly, although H. pylori infection is considered as the main risk factor for gastric cancer, the correlation between the rs3787016 polymorphism and gastric cancer risk remained statistically significant even after adjusting for several variables, including H. pylori infection which indicates that the POLR2E rs3787016 polymorphism is an independent risk factor for gastric cancer.…”

“…Similar results have also been reported in the Chinese and Iranian populations [14,16], albeit no significant association of rs3787016 with the PCa risk and standard prognostic parameters regarding PCa progression have been identified in the Serbian population [15]. Moreover, further studies have also been conducted for several other cancer types, and it has been reported that POLR2E rs3787016 polymorphism is significantly associated with the risk for breast cancer, cervical cancer, esophageal cancer, and papillary thyroid carcinoma [20][21][22][23],…”

“…According to a recent report, SNP rs3787016 (A>G), localized in the fourth intron of the RNA polymerase II subunit E (POLR2E) lncRNA gene [13], may serve as a genetic risk factor for different types of cancer including prostate cancer (PCa) [14][15][16], lung cancer [17], liver cancer [17], breast cancer [18,19], cervical cancer [18], esophageal cancer [20], papillary thyroid carcinoma [21], and glioma [22]. Although the literature presents conflicting notions, it is believed that rs3787016 may serve as a genetic factor that affects the susceptibility to cancer.…”

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

“…Rs3787016, localizes to the fourth intron of RNA polymerase II polypeptide E (POLR2E) 16 gene, has been investigated by several researchers on its association with cancer risk [16,[30][31][32][33][34][35][36][37].The most important function of LncRNAs is involvement in the transcriptional or posttranscriptional regulation of gene expression [38]. Abnormal expressions of these RNAs facilitate tumor-cell proliferation, invasion and survival in cancer development and progression [39][40][41].…”

miR-499 rs3746444 and miR-196a-2 rs11614913 Are Associated with the Risk of Glioma, but Not the Prognosis

“…Peripheral blood samples were collected from the subjects. Genomic DNA was extracted from peripheral blood using the Universal Genomic DNA Extraction Kit (TaKaRa, Kyoto, Japan) 37 and measured by spectrophotometry (DU530 UV-visible [vis] spectrophotometer; Beckman Instruments, Fullerton, CA, USA). 38 The Multiplexed SNP Mass Extend assay was designed using Sequenom Mass Array Assay Design (version 3.0; Agena Bioscience, San Diego, CA, USA).…”