Ficus carica extract impregnated amphiphilic polymer scaffold for diabetic wound tissue regenerations

Abstract

Diabetes associated injury healing and other tissue irregularities are viewed as a significant concern. The purpose of the study is to design the wound regeneration activity of Ficus carica extract (FFE) loaded amphiphilic polymeric scaffold of poly(xylitol-g-adipate-co-glutamide) (PXAG)-polyhydroxybutyrate (PHB) for potential diabetic affected wound regeneration. The PXAG copolymer was prepared by the condensation method, and the polymeric scaffolds of PXAG-PHB, PXAG-PHB/FFE were developed through the ultra-sonication process and magnetic stirrer processes. The chemical structure, crystalline nature, thermal stability, size, surface charge and surface morphology of PXAG-PHB and PXAG-PHB/FFE polymeric scaffolds were investigated. The PXAG-PHB/FFE exhibits 99.0% free radical scavenging activity which was determined by the DPPH method. The inhibition zones by the PXAG-PHB/FFE indicate it had a higher antibacterial activity with the Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) pathogens. The PXAG, PXAG-PHB and PXAG-PHB/FFE polymeric scaffolds exhibited good viability against diabetic induced wound cells (WS1) in 100 lg/mL concentrations up to 72 h incubation. Since the synthesized PXAG-PHB/FFE polymeric scaffolds possess excellent thermal stability, bioactivity, biocompatibility and antioxidant activity along with potent antimicrobial activity, they play a potential role in diabetic wound tissue regenerations.

Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications

“…These bioelastomers, when blended with polyhydroxy butyrate and Ficus carica extract, have shown promising results in terms of thermal stability, bioactivity, and biocompatibility. These findings indicate that blends could be significant in diabetic wound tissue engineering applications 24 . Furthermore, successful blending of poly (mannitol sebacate) with polylactic acid has been achieved to regulate viscosity for electrospinning purposes.…”

“…The analysis of the relative migration percentage of blends and bioelastomers within 24 h in Figure 7 diabetic wound cells. 24 Nevertheless, the parameters, such as the percentage of relative migration and complete healing of wounds compared to scratch test sources, indicate that these samples meet the biocompatibility criteria. [35][36][37] However, Figures 5 and 6 reveal no observable deformation in cell morphology, indicating that all samples are highly biocompatible.…”

“…These findings indicate that blends could be significant in diabetic wound tissue engineering applications. 24 Furthermore, successful blending of poly (mannitol sebacate) with polylactic acid has been achieved to regulate viscosity for electrospinning purposes. Nonetheless, it should be noted that an increase in the percentage of polylactic acid has led to the observation of inflammation in the rat's body.…”

“…25,26 Moreover, it has been observed that this particular family of bioelastomers can be combined with minerals, vitamins, and drugs to create suitable composites for drug delivery and tissue engineering applications. 24,[27][28][29][30] Through the blending of poly (glycerol sebacate) with polycaprolactone, it has been demonstrated that it is possible to maintain biocompatibility at a level comparable to pure poly (glycerol sebacate) while also achieving a wide range of mechanical properties. 31 Piatek-Hnat et al studied the effects of radiation modification of sugar alcohol-based bioelastomers and reported that these polymers are well-suited for radiation modification.…”

Effect of aqueous extract of fig fruit (Ficus Carica) on wound healing in albino rabbits

“…Figs can increase the metabolic activity of the kidneys, which leads to an increase in the excretion of harmful substances in the urine in patients who consume figs. Uric acid combines with malic acid in figs to increase bile secretion, which is effective in the treatment of liver disease (13). Nowadays, wound healing is one of the most important aims of medical science.…”