<i>Fusobacterium nucleatum</i> impedes remission of colitis in a mouse model

Yamashita, Taiga; Tai, Shoya; Tsukahara, Takamitsu; Inoüe, Ryo

doi:10.1093/bbb/zbab029

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…Regarding F. nucleatum, it is a common member of the oral core microbiome; however, because of its proinflammatory potential, it has been associated with various periodontal diseases, with its increase also related to the severity of disease and the progression of inflammation [58]. Furthermore, F. nucleatum has been detected as being significantly enriched in the gut in IBD and UC subjects [4,59,60], being related even to the promotion of colitis, its aggravation, and the impediment of the remission [61][62][63], as well as having been found to cause opportunistic infections, and to be associated with colorectal cancer and IBD [64].…”

Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis

Molinero

Taladrid

Zorraquín‐Peña

et al. 2022

CIMB

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Ulcerative colitis (UC) is a recurrent pathology of complex etiology that has been occasionally associated with oral lesions, but the overall composition of the oral microbiome in UC patients and its role in the pathogenesis of the disease are still poorly understood. In this study, the oral microbiome of UC patients and healthy individuals was compared to ascertain the possible changes in the oral microbial communities associated with UC. For this, the salivary microbiota of 10 patients diagnosed with an active phase of UC and 11 healthy controls was analyzed by 16S rRNA gene sequencing (trial ref. ISRCTN39987). Metataxonomic analysis revealed a decrease in the alpha diversity and an imbalance in the relative proportions of some key members of the oral core microbiome in UC patients. Additionally, Staphylococcus members and four differential species or phylotypes were only present in UC patients, not being detected in healthy subjects. This study provides a global snapshot of the existence of oral dysbiosis associated with UC, and the possible presence of potential oral biomarkers.

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Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis

Molinero

Taladrid

Zorraquín‐Peña

et al. 2022

CIMB

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“…Vibrio is pathogenic to the gastrointestinal tract, particularly in immunocompromised individuals ( 59 , 60 ). Fusobacterium was reported to easily impede colitis remission in mice ( 61 ). Anaerobiospirillum succiniciproducens is a rare cause of bacteremia in humans and can cause intestinal infection ( 62 ).…”

Section: Discussionmentioning

confidence: 99%

“…Here, these indicators were significantly lower in the PNE100 group than in the CON, PNE200, and PNE400 groups. These serum parameters were positively correlated with Anaerobiospirillum ( 62 ), Vibrio ( 59 ), Fusobacterium ( 61 ), and Shewanella ( 58 ), which are infectious pathogens. To the best of our knowledge, no study has reported the effects of pine needles on poultry intestinal flora, particularly in laying hens.…”

Section: Discussionmentioning

confidence: 99%

Pine (Pinus massoniana Lamb.) Needle Extract Supplementation Improves Performance, Egg Quality, Serum Parameters, and the Gut Microbiome in Laying Hens

et al. 2022

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The effects of Masson pine (Pinus massoniana Lamb.) needle extract (PNE) on gastrointestinal disorders and oxidative stress have been widely investigated using experimental models; however, the functions and mechanisms of these effects in chicken models remain unknown. We investigated the effects of Masson PNE supplementation on performance, egg quality, serum parameters, and the gut microbiome in laying hens. A total of 60 healthy 50-week-old Peking Pink laying hens with similar body conditions and egg production were randomly divided into the control (CON) (0 mg/kg PNE), PNE100 (100 mg/kg PNE), PNE200 (200 mg/kg PNE), and PNE400 (400 mg/kg PNE) groups, with fifteen replicates per treatment and one hen per replicate. Compared with the CON group, egg mass, feed conversion ratios, and yolk weight were significantly increased (p < 0.01) in the PNE100 group. Dietary supplementation of 100 mg/kg PNE increased the serum total protein, albumin, and glucose concentrations (p < 0.01) and decreased the alanine aminotransferase activity (p < 0.05) compared with those of the CONs. Hens in the PNE100 group had reduced serum malondialdehyde levels (p < 0.05) and increased catalase, superoxide dismutase, and glutathione peroxidase activities (p < 0.01) compared with those of the CON group. Serum proinflammatory cytokine concentrations of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α were lower (p < 0.01) and the IL-10 level was higher (p < 0.01) in the PNE100 group than in the CON group. Serum immunoglobulin (Ig)A, IgG, and IgM concentrations were increased in the PNE100 group (p < 0.01). The relative abundance of Bacteroidetes was increased, while the relative abundances of Firmicutes and Proteobacteria were decreased in the PNE100 group. The relative abundances of Vibrio, Shewanella, and Lactobacillus were decreased, while the relative abundances of unclassified_o_Bacteroidales, Rikenellaceae_RC9_gut_group, unclassified_f_Rikenellaceae, and Butyricicoccaceae were increased in the PNE100 group compared with those of the CON group. PNE supplementation at 100 mg/kg improved the diversity and structure of the gut microbial composition, production performance, egg quality, and serum parameters of laying hens. The laying hens in this study had good production performance when supplemented with 100 mg/kg PNE.

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“…15 Studies have shown that the elevated presence of F. nucleatum in colon can imped colitis remission and promote the initiation, progression, and metastasis of colorectal cancer. 10,35 Here, we established a F. nucleatum and DSS-coinduced UC mice model and demonstrated that chronic KS treatment ameliorated this colitis murine model. Consistent with reported studies, the increasing abundance of F. nucleatum aggravated the clinical symptoms of DSS-induced colitis.…”

Section: Ros-scavenging Effectmentioning

confidence: 97%

Regulation of Gut Microbiota and Microbial Metabolome of Kefir Supernatant against Fusobacterium nucleatum and DSS-Coinduced Colitis

Zeng,

Li,

Wang

et al. 2024

J. Agric. Food Chem.

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The aim of this study was to investigate the intervention effect of kefir supernatant (KS) on the initiation and progression of an ulcerative colitis (UC) murine model. We established an UC murine model by orally administrating with 10 9 CFUs of Fusobacterium nucleatum for 3 weeks and 3% dextran sulfate sodium (DSS) treatment in the third week. KS was used to intervene in this colitis model. Our results showed that KS supplementation ameliorated the symptoms, restrained the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-17F), promoted the release of anti-inflammatory cytokines (IL-4 and IL-10), and ameliorated oxidative stress. Furthermore, the increased number of goblet cells and upregulated expression of MUC2, occludin and claudin-1 indicated that the colon barrier was protected by KS. Additionally, KS supplementation mitigated gut microbiota dysbiosis in the UC murine model, leading to an increase in the abundance of Blautia and Akkermansia and a decrease in the level of Bacteroides. The altered gut microbiota also affected colon metabolism, with differential metabolites mainly associated with the biosynthesis of the L-arginine pathway. This study revealed that KS supplementation restored the community structure of gut microbiota, altered the biosynthesis of L-arginine, and thereby modulated the process of colonic inflammation.

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Fusobacterium nucleatum impedes remission of colitis in a mouse model

Cited by 6 publications

References 35 publications

Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis

Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis

Pine (Pinus massoniana Lamb.) Needle Extract Supplementation Improves Performance, Egg Quality, Serum Parameters, and the Gut Microbiome in Laying Hens

Regulation of Gut Microbiota and Microbial Metabolome of Kefir Supernatant against Fusobacterium nucleatum and DSS-Coinduced Colitis

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