<i>Fusobacterium nucleatum</i> is associated with inflammation and poor survival in early-stage HPV-negative tongue cancer

Desai, Sanket; Dharavath, Bhasker; Manavalan, Sujith; Rane, Aishwarya; Redhu, Archana Kumari; Sunder, Roma; Butle, Ashwin; Mishra, Rohit; Joshi, Asim; Togar, Trupti; Apte, Shruti; Bala, Pratyusha; Chandrani, Pratik; Chopra, Supriya; Bashyam, Murali D.; Banerjee, Anirban; Prabhash, Kumar; Nair, Sudhir; Dutt, Amit

doi:10.1093/narcan/zcac006

Cited by 18 publications

(23 citation statements)

References 80 publications

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“…Specifically, an abundance of Fusobacterium nucleatum and Porphyromonas gingivilis is clinically correlated with poor survival in HNSCC in a site-specific manner. 40,102 Poor survival outcomes with Fusobacterium abundance has been also previously reported in colorectal cancer, wherein the authors proposed development of preventive and treatment strategies targeting intestinal microflora by probiotics and antibiotics. 103 Use of antibiotics in colorectal adenocarcinoma in-vivo models have shown to have positive impact on disease outcomes and in preventing metastases.…”

Section: Clinical and Therapeutic Relevance Of Microbiome In Hnsccmentioning

confidence: 84%

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Desai

2023

Cancer Reports

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BackgroundHead and neck cancer (HNSCC) is a heterogeneous group of cancers, affecting multiple regions such as oral cavity, pharynx, larynx, and nasal region, each showing a distinct molecular profile. HNSCC accounts for more than 6 million cases worldwide, soaring mainly in the developing countries.Recent findingsThe aetiology of HNSCC is complex and multifactorial, involving both genetic and environmental factors. The critical role of microbiome, which includes bacteria, viruses, and fungi, is under spotlight due to the recent reports on their contribution in the development and progression of HNSCC. This review focuses on the effect of opportunistic pathogens on the host genome and epigenome, which contributes to the disease progression. Drawing parallels from the host‐pathogen interactions observed in other tumour types arising from the epithelial tissue such as colorectal cancer, the review also calls attention to the potential explorations of the role of pathogens in HNSCC biology and discusses the clinical implications of microbiome research in detection and treatment of HNSCC.ConclusionOur understanding of the genomic effects of the microbes on the disease progression and the mechanistic insights of the host‐pathogen interaction will pave way to novel treatment and preventive approaches in HNSCC.

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Section: Clinical and Therapeutic Relevance Of Microbiome In Hnsccmentioning

confidence: 84%

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Desai

2023

Cancer Reports

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“…As a foil to this limitation, we were encouraged to see a recent example of a robust sample collection method described in Desai et al ( 2022 ); these authors specified that their OSCC data was derived from only fresh-frozen primary tumors of tongue origin. We recommend that such specific criteria become the norm for studies in this field.…”

Section: Analysis Of Results and Discussionmentioning

confidence: 99%

Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome

Peter

Withanage²,

Comnick³

et al. 2022

Front. Microbiol.

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The intersection between the human oral microbiome and oral health is an emerging area of study which has gained momentum over the last decade. This momentum has motivated a search for associations between the oral microbiome and oral cancer, in hopes of identifying possible biomarkers that facilitate earlier diagnosis and improved prognosis for patients with that disease. The present study examined the relationship between the microbiome in the human oral cavity and oral squamous cell carcinoma (OSCC). We searched the literature for case-control studies which focused on the relationship between the human oral microbiome and OSCC. We aggregated three types of data from these studies: bacteriome data at the genus level, predicted functional pathway data, and gene abundance data. From these data, we noted several microbial genera which may be associated with oral cancer status, including Fusobacterium. We also identified functional pathways which merit further investigation, including RNA degradation (ko03018) and primary immunodeficiency (ko05340). In addition, our analysis of gene abundance data identified the gene K06147 (ATP-binding cassette, subfamily B, bacterial) as being over abundant in OSCC samples. Our results are generalizations which identified some currents that we believe could guide further research. Our work faced several limitations related to the heterogeneity of the available data. Wide variation in methods for sample collection, methods for controlling for known behavioral risk factors, computing platform choice, and methods for case-control design all posed confounding factors in this work. We examined the current methods of data collection, data processing, and data reporting in order to offer suggestions toward the establishment of best practices within this field. We propose that these limitations should be addressed through the implementation of standardized data analytic practices that will conform to the rigor and reproducibility standards required of publicly funded research.

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“…In oral cancer, specifically tongue cancer, F. nucleatum was associated with poor survival, nodal metastases and extracapsular spread [56 ▪ ]. Interestingly, a recent study by Neuzillet et al reported contradictory results where F. nucleatum was associated with lower recurrence rate, significantly longer overall survival, relapse-free and metastasis-free survival [57].…”

Section: Fusobacteria As a Biomarker For Cancer Diagnosis And Prognosismentioning

confidence: 99%

The role of Fusobacteria in oral cancer and immune evasion

Harrandah

2023

Current Opinion in Oncology

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Purpose of reviewThere is growing evidence that suggests a possible role for bacteria in the progression of cancer. Fusobacteria have been detected in different types of cancers, including colorectal and oral cancers. Fusobacteria are common opportunistic oral bacteria known to cause various infections. In this review, we focus on the association between Fusobacteria and cancer, specifically oral cancer, and provide insight into the role of Fusobacteria in carcinogenesis and immune evasion.Recent findingsRecently, it has been suggested that Fusobacteria are among the bacteria that contribute to the progression of cancer and might affect disease prognosis and treatment outcome. Moreover, Fusobacteria might alter tumor microenvironment and have an impact on tumor immune response. Thus, understanding the effect of Fusobacteria on cancer cells and tumor microenvironment is crucial to improve treatment outcome.SummeryRecent evidences suggest that Fusobacteria not only have an impact on tumor progression, but might also affect tumor immune response. Moreover, Fusobacteria presence in the tumor microenvironment might have an impact on treatment outcome and might be used as a prognostic factor.

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Fusobacterium nucleatum is associated with inflammation and poor survival in early-stage HPV-negative tongue cancer

Cited by 18 publications

References 80 publications

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome

The role of Fusobacteria in oral cancer and immune evasion

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