Ganoderma triterpenoids attenuate tumour angiogenesis in lung cancer tumour-bearing nude mice

Zerumbone combined with gefitinib alleviates lung cancer cell growth through the AKT/STAT3/SLC7A11 axis

“…Simultaneously, western blot results revealed that the expression levels of VEGFR2, and EGFR decreased while angiostatin, and endostatin expression levels increased. Angiostatin, and endostatin are inhibiting factors of angiogenesis, the increasing level means the decreasing angiogenesis [27,28]. Our results indicated that zerumbone could inhibited tumor angiogenesis, zerumbone combined with gefitinib was more effectively.…”

Lucialdehyde B suppresses proliferation and induces mitochondria-dependent apoptosis in nasopharyngeal carcinoma CNE2 cells

“…G. lucidum triterpenoids exhibit a wide variety of antitumor activities by blocking the cell cycle, inducing apoptosis and autophagy, and inhibiting tumor metastasis and angiogenesis (Liu et al. 2020 ). The Ras/ERK signaling pathway is an important signaling system mediating cell responses in mammals and plays an important role in the survival, proliferation, differentiation, and apoptosis of tumor cells (Ali et al.…”

Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity ofGanodermameroterpenoids

“…7) at a time when phytochemists mainly focused on polysaccharide and triterpenoids as the main bioactive constituents of Ganoderma (Ganodermataceae, Basidiomycete). [8][9][10][11][12] However, the discovery of (±)-lingzhiol (3) (Fig. 1) with an unprecedented [4.3.3]propellane skeleton from G. lucidum 13 in 2014 indicated the possibility of structural diversity in GMs, arousing other phytochemists to extensively Xing-Rong Peng was born in Baoshan, China, in 1987.…”