<i>Gastrodia elata</i> BI.:A Comprehensive Review of Its Traditional Use, Botany, Phytochemistry, Pharmacology, and Pharmacokinetics

Wu, Ya-Nan; Wen, Si-Hua; Zhang, Wei; Yu, Shangshang; Yang, Kai; Liu, Ding; Zhao, Chongbo; Sun, Jing

doi:10.1155/2023/5606021

Cited by 17 publications

(6 citation statements)

References 55 publications

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“…Mailuoning injection, the composite traditional Chinese medicine preparation, has been clinically recognized for its ability to enhance blood flow, prevent clot formation, nourish yin, and dissipate heat 11,12 . It comprises a blend of potent ingredients including Achyranthes bidentata, honeysuckle, Radix Scrophulariae, and Dendrobium, each offering unique therapeutic benefits ranging from improving circulation and reducing inflammation to nourishing bodily fluids and alleviating pain 13 . Modern pharmacological studies confirm that these components synergistically improve blood coagulation parameters and enhance vascular circulation, underlining the injection's efficacy in treating vascular diseases such as thromboangiitis obliterans and ischemic cerebrovascular disease 14,15 .…”

Section: Discussionmentioning

confidence: 99%

“… 11 , 12 It comprises a blend of potent ingredients including Achyranthes bidentata, honeysuckle, Radix Scrophulariae, and Dendrobium, each offering unique therapeutic benefits ranging from improving circulation and reducing inflammation to nourishing bodily fluids and alleviating pain. 13 Modern pharmacological studies confirm that these components synergistically improve blood coagulation parameters and enhance vascular circulation, underlining the injection's efficacy in treating vascular diseases such as thromboangiitis obliterans and ischemic cerebrovascular disease. 14 , 15 Despite its widespread use and acknowledged therapeutic effects, precise mechanisms underlying Mailuoning's beneficial actions are still being elucidated.…”

Section: Discussionmentioning

confidence: 99%

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Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study

Xiao,

Xie,

Liu

et al. 2023

International Wound Journal

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Thrombophlebitis is the inflammatory condition characterized by obstruction of one or more vessels, commonly in the legs, due to the formation of blood clots. It has been reported that traditional Chinese medicine, including Mailuoning injection, is advantageous for treating inflammatory and blood disorders. This research assessed the therapeutic efficacy of Mailuoning injection in the treatment of thrombophlebitis in rodents, as well as investigated its impact on fibrinolysis, inflammation, and coagulation. An experimental setup for thrombophlebitis was established in rodents via modified ligation technique. Five groups comprised the animals: sham operation group, model group, and three Mailuoning treatment groups (low, medium, and high dosages). The pain response, edema, coagulation parameters (PT, APTT, TT, FIB), serum inflammatory markers (IL‐6, TNF‐α, CRP), and expression levels of endothelial markers (ICAM‐1, VCAM‐1, NF‐κB) were evaluated. Blood flow and vascular function were further assessed by measuring hemorheological parameters and the concentrations of TXB2, ET, and 6‐k‐PGF1α. In contrast to the sham group, model group demonstrated statistically significant increases in endothelial expression levels, coagulation latencies, and inflammatory markers (p < 0.05). The administration of mailing, specifically at high and medium dosages, resulted in a substantial reduction in inflammatory markers, enhancement of coagulation parameters, suppression of ICAM‐1 and VCAM‐1 expression, and restoration of hemorheological measurements to baseline (p < 0.05). Significantly higher concentrations of 6‐k‐PGF1α and lower levels of TXB2 and ET were observed in high‐dose group, suggesting that pro‐ and anti‐thrombotic factors were restored to equilibrium. Utilization of Mailuoning injection in rat model of thrombophlebitis exhibited significant therapeutic impact. This effect was manifested through pain alleviation, diminished inflammation, enhanced blood viscosity and facilitation of fibrinolysis. The study indicated that Mailuoning injection may serve as a viable therapeutic option for thrombophlebitis, potentially aiding in the improvement of wound healing by virtue of its anti‐inflammatory and blood flow‐enhancing characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study

Xiao,

Xie,

Liu

et al. 2023

International Wound Journal

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“…Gastrodia elata BI. has been used in many physicians to treat cerebrovascular and cardiovascular diseases, such as stroke, migraine, cardiac hypertrophy, fibrosis and hypertension 19,[33][34][35][36] . In addition, gastrodin is one of the practical components of Gastrodia elata BI., which has attracted great interest in the research of anti-cardiac injury.…”

Section: Disscussionmentioning

confidence: 99%

Gastrodin alleviates angiotensin Ⅱ-induced hypertension and myocardial apoptosis and PRDX2/p53 pathway activation

Xu,

Xie,

et al. 2024

Preprint

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Gastrodin is one of the foremost effective components of traditional Chinese medicine Gastrodia elata Bl., which has been widely used for anti-hypertension in China. However, the protection from myocardial apoptosis in hypertension of gastrodin has not been systematic studied. Our current study investigated the therapeutic effects and underlying mechanisms of gastrodin on cardiac protection in hypertensive mice. Treatment of gastrodin in Ang II-infused C57BL/6 mice significantly alleviated the increase of blood pressure, cardiac dysfunction, heart tibial ratio, and cardiac pathological changes. Kyoto Encyclopedia of Genes and Genomes pathway analyses applied in the data of RNA-sequencing by gastrodin treatment identified 697 up-regulated transcripts and 714 down-regulated transcripts, as well as 1105 enriched signaling pathways, which also revealed that apoptosis and PRDX2/p53 pathway were involved in the cardiac protection role of gastrodin. Consistently, gastrodin treatment significantly reduced the cell apoptosis in cardiac tissues of Ang II-infused mice and Ang II-stimulated H9c2 cells. In addition, gastrodin treatment significantly also decreased the Bax/Bcl-2 ratio on protein level, and down-regulated the protein levels of cleaved-caspase3, cleaved-caspase9, PRDX2 and p53 in both cardiac tissues and H9c2 cells stimulated with Ang II. In conclusion, gastrodin treatment exhibits cardiac protection by reducing myocardial apoptosis and suppressing PRDX2/p53 pathway activation in vitro and in vivo.

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“…Gastrodia elata (Orchidaceae), a fully mycoheterotrophic orchid plant, has been used for medicinal purposes in eastern Asian countries (Wu et al, 2023;Zhan et al, 2016). G. elata is achlorophyllous and completes its life cycle by relying entirely on certain fungi, including some species of Armillaria (Basidiomycota, Agaricales, Physalacriaceae) (Hua et al, 2024).…”

Section: Introductionmentioning

confidence: 99%

Genetic transformation tools for an Armillaria species, a resource for studying the interaction between Armillaria fungus and the fully mycoheterotrophic plant Gastrodia elata

Lei,

Su,

et al. 2024

Preprint

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The genus Armillaria (Basidiomycota, Agaricales, Physalacriaceae) comprises pathogenic fungi that cause root-rot disease in plants, as well as species with low pathogenicity, some of which are hosts of the fully mycoheterotrophic orchid plant Gastrodia elata (Orchidaceae). To investigate the mechanisms underlying such special interactions between Armillaria fungi and G. elata, it is crucial to establish genetic transformation platforms for the Armillaria fungi and G. elata. In this study, an Armillaria strain Arm37 was isolated from G. elata, which can form symbiosis with G. elata in axenic culture under laboratory conditions. A vector pYT-EV containing a cassette for hygromycin-resistance selection and a cassette for expressing or silencing target genes was constructed. An Agrobacterium tumefaciens (Agrobacterium)-mediated transformation (AMT) system for Arm37 was successfully developed and optimized to achieve a transformation efficiency 32%. The AMT system was successfully used to express the reporter genes enhanced green fluorescent protein (eGFP) and β-glucuronidase (GUS) and to effectively silence the endogenous gene orotidine 5'-monophosphate decarboxylase (URA3) in Arm37. This AMT system established for Arm37 provides an efficient genetic tool for exploring the Arm37 genes that are involved in the unique interaction between the Armillaria fungi and fully mycoheterotrophic plant G. elata.

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Gastrodia elata BI.:A Comprehensive Review of Its Traditional Use, Botany, Phytochemistry, Pharmacology, and Pharmacokinetics

Cited by 17 publications

References 55 publications

Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study

Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study

Gastrodin alleviates angiotensin Ⅱ-induced hypertension and myocardial apoptosis and PRDX2/p53 pathway activation

Genetic transformation tools for an Armillaria species, a resource for studying the interaction between Armillaria fungus and the fully mycoheterotrophic plant Gastrodia elata

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