<i>Gerbillus nanus</i>(Rodentia: Muridae): a new reservoir host of<i>Leishmania major</i>

Azizi, Kourosh; Moemenbellah‐Fard, Mohammad Djaefar; Fakoorziba, Mohammad Reza; Fekri, Sajjad

doi:10.1179/1364859411y.0000000036

Cited by 21 publications

(17 citation statements)

References 17 publications

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“…The first one has been located in central and northeast of Iran, where Rhombomys opimus Lichtenstein and Phlebotomus papatasi Scopoli (P. papatasi) play important roles as reservoirs and vectors of the disease [3] . The second foci are located in the west and southwest of Iran, where Tatera indica Hardwicke (T. indica) is replaced with Rhombomys opymus as a reservoir and P. papatasi as a vector [8] . Baluchistan province, in the southeast of Iran is considered as the third focus of L. major and Meriones hurrianae Jordon has been approved as its natural reservoir host [9] .…”

Section: Discussionmentioning

confidence: 99%

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First detection of Leishmania infantum DNA in wild caught Phlebotomus papatasi in endemic focus of cutaneous leishmaniasis, South of Iran

Rassi

Hadi

Reza

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

“…This fact confirms that T. indica is the principal reservoir of L. major in Farashband city. Leishmania infection of T. indica has been reported in west and southwest of Iran with 12.5% and 9.0% positive cases respectively [8] . In a study in southeastern Iran L. major was found to be 3.7% infection in this region.…”

Section: Discussionmentioning

confidence: 99%

First detection of Leishmania infantum DNA in wild caught Phlebotomus papatasi in endemic focus of cutaneous leishmaniasis, South of Iran

Rassi

Hadi

Reza

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…This could be due to the different climatic and geographical conditions of their study area compared ours. Meriones persicus , T. indica , M. hurrianae and G. nanus were also trapped from Jask County, Hormozgan Province by Azizi et al (2011) (8). Leishmania parasite was isolated from M. hurrianae , T. indica and G. nanus using microscopy and molecular methods, while M. persicus was the most prevalent species in the area.…”

Section: Discussionmentioning

confidence: 99%

“…Both epidemiological forms of CL are present in the country; Zoonotic CL (ZCL), caused by L. m ajor and anthroponotic CL (ACL) caused by L. tropica . In a new focus of CL in Poledokhtar District, the results of polymerase chain reaction (PCR) assays indicated that 96.15% of cases were L. major, whereas 3.85% were L. tropica (13)(14)(15) (21)(22)(23). The Sistan-Baluchistan Province, Southeastern Iran, is considered as the focus of ZCL in Iran (24)(25)(26) and the disease has become a major health problem in rural areas of Chabahar and Mirjaveh Counties of this province, as old foci of the disease.…”

Section: Introductionmentioning

confidence: 99%

A Biosystematic and Morphometric Investigation of the Characters of Rodents (Mammalia: Rodentia) as Reservoir Hosts for Zoonotic Cutaneous Leishmaniasis in an Endemic Focus of Sistan-Baluchistan Province, Iran

Kassiri

Sharififard

2015

Arch Clin Infect Dis

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Background: Rodents play a major role in economic losses and public health problems. These animals are considered as natural reservoir hosts of Zoonotic Cutaneous Leishmaniasis (ZCL), one of the major health concerns in Iran. Objectives: This research was aimed to study rodents' diversity and faunistic of Chabahar County, Sistan-Baluchistan Province, Southeastern Iran, as an old ZCL focus. Materials and Methods:Trappings were randomly performed with 20 Sherman live-traps at four localities from Chabahar County, continuously during 5 months. In the laboratory, the animal skin was entirely removed and taxidermy was performed. Four standard external characters and seven cranial variables were measured using a ruler and vernier calipers, respectively. The collected specimens were identified with respect to their morphological, external, cranial and dental characteristics. A relevant key was used for identification. Sampling was performed in different places from vegetation covering around rodent burrows. These two species were found in all study areas, with high abundance. They live socially in large parts of area lands, with a very large number of rodent burrows. Standard external morphologic and morphometric characters of M. hurrianae and T. indica , including cranial and dental, are given. Conclusions:The spatial and temporal monitoring of wild rodents will help to predict the potential zoonotic rodent-borne diseases.

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“…They are manifested in severity from skin scars to serious disfigurement and fatal systemic infection (WHO 2010). Transmission to the vertebrate host is by Phlebotomus sand flies from a reservoir host to humans (Moemenbellah-Fard et al 2003;Azizi et al 2011).…”

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confidence: 99%

In vitro efficacy of ethanolic extract of Artemisia absinthium (Asteraceae) against Leishmania major L. using cell sensitivity and flow cytometry assays

et al. 2014

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Leishmaniasis is one of the most neglected human diseases with an estimated global burden ranking second in mortality and fourth in morbidity among the tropical infections. Chemotherapy involving the use of drugs like glucantime is the mainstay treatment in endemic areas of Iran. Drug resistance is increasingly prevalent, so search for alternative therapy is gathering pace. Medicinal herbs, like wormwood Artemisia, have chemical compounds effective against a number of pathogens. In this study, the efficacy of ethanol extract from Artemisia absinthium (Asteraceae) against Leishmania major L. was investigated in vitro. The outcome of different effective doses (1-40 mg/ml) of ethanol extracts from this medicinal herb, A. absinthium, on a standard Iranian parasite strain of L. major was examined. The L. major promastigote cell sensitivity and mortality or viability effects due to the addition of herbal extract were measured using the MTT assay and the flow cytometry technique, respectively. There was complete agreement between the two assays. The lethal concentration (LC50) was measured as 101 mg/ml. Some contrasting relationships between the medicinal herb concentrations and the viability of parasites were observed; so that there was an increased multiplication of the parasite at low concentrations of the drug, but an anti-parasitic apoptotic effect was seen at high concentrations of A. absinthium. It was concluded that there might be one or more chemical constituents within the herbal extract of wormwood which at high concentration controlled cell division and affected the relevant activity within the only one giant mitochondrion in this flagellate parasite. At low doses, however, it showed the opposite effect of leading to mitotic cell divisions.

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Gerbillus nanus(Rodentia: Muridae): a new reservoir host ofLeishmania major

Cited by 21 publications

References 17 publications

First detection of Leishmania infantum DNA in wild caught Phlebotomus papatasi in endemic focus of cutaneous leishmaniasis, South of Iran

First detection of Leishmania infantum DNA in wild caught Phlebotomus papatasi in endemic focus of cutaneous leishmaniasis, South of Iran

A Biosystematic and Morphometric Investigation of the Characters of Rodents (Mammalia: Rodentia) as Reservoir Hosts for Zoonotic Cutaneous Leishmaniasis in an Endemic Focus of Sistan-Baluchistan Province, Iran

In vitro efficacy of ethanolic extract of Artemisia absinthium (Asteraceae) against Leishmania major L. using cell sensitivity and flow cytometry assays

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