Ginkgo biloba leaf extract (EGb 761) diminishes adriamycin‐induced hyperlipidaemic nephrotoxicity in rats: association with nitric oxide production

Abstract

The aim of this experimental study was to investigate the effect of a standardized preparation of Ginkgo biloba extract (EGb 761) on the hyperlipidaemic nephrotoxicity and oxidative stress induced by a single intravenous injection (5 mg/kg) of adriamycin. EGb 761 was received daily thereafter by a gavage at the dose of 100 mg/kg for 35 consecutive days. EGb 761 administration significantly attenuated adriamycin-induced renal dysfunction, as assessed by measuring serum lipid profile, serum total protein, serum urea and Ccr (creatinine clearance). Furthermore, urinary excretions of protein and NAG (N-acetyl-beta-D-glucosaminidase; a marker of renal tubular injury) were significantly inhibited following EGb 761 administration. EGb 761 supplementation significantly prevented the generation of TBARS (thiobarbituric acid-reacting substances) with a marked improvement in terms of GSH content and activity of antioxidant enzymes in the kidney homogenate. Moreover, EGb 761 treatment significantly reduced both renal-tissue and urine total NO (nitric oxide) levels. The results suggest that the protective potential of EGb 761 in the prevention of adriamycin-induced hyperlipidaemic nephrotoxicity in rats was associated with the decrease in the oxidative stress and the total NO levels of renal tissues. Likewise, the present study demonstrates the ability of EGb 761 to reduce the hyperlipidaemia and proteinuria associated with this nephropathy, which might be beneficial to enhance the therapeutic index of adriamycin.

Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression

“…The GB improved the renal function in the MTX group confirming its nephroprotective effect and this was in harmony with other studies that reported amelioration of the renal function with the GB administration in models of diabetic nephropathy [10] as well as models of induced nephrotoxicity by cisplatin [30], adriamycin [31], and MTX [4].…”

Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

“…Furthermore, Ginkgo biloba has a vascular rescuing effect as well as an antiapoptotic effect [ 11 – 13 ]. In addition, it has been shown that Ginkgo biloba could rescue renal injury in brain death induced-nephrotoxicity [ 14 ] and adriamycin-induced hyperlipidemic nephrotoxicity [ 15 ] and in uranium-treated mice [ 16 ].…”

Ginkgo biloba Extract Attenuates Methotrexate-Induced Testicular Injury in Rats: Cross-talk Between Oxidative Stress, Inflammation, Apoptosis, and miRNA-29a Expression

“…Several reports showed an effective protective effect of GIN in different models of neurotoxicity 26 and hepatotoxicity, 27 in addition to nephrotoxicity. 28 , 29 Moreover, the protective effect of GIN against testicular toxicity induced by cisplatin, 25 doxorubicin, 30 cadmium, 31 and cellphone radiation 32 was reported. Nevertheless, the impact of GIN versus MTX-induced gonadotoxicity is still not been identified yet.…”