<i>Gryllus bimaculatus</i> extract protects against lipopolysaccharide and palmitate-induced production of proinflammatory cytokines and inflammasome formation

Park, Woo‐Jae; Han, Jung‐Soon

doi:10.3892/mmr.2021.11845

Cited by 17 publications

(13 citation statements)

References 41 publications

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“…Reduction of the inflammatory cytokines occurred by suppression of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB signaling) and mitogen-activated protein kinase (MAPK), which are crucial cell signaling pathways for cytokine production (Figure 4). G. bimaculatus decreased inflammatory cytokines by suppression of inflammasome formation [74]. The immunohistological analysis also showed that the ethanolic extract of G. bimaculatus inhibited IL-1β level in liver Kupffer cells of mice treated with alcohol [72].…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 84%

“…For antioxidant activities, the ethanolic extract of G. bimaculatus, displayed vitamin C equivalent antioxidant capacities against DPPH radicals at 25.4 mg/g sample [72], while cricket protein isolate (CPI) from G. bimaculatus exhibited DPPH scavenging activity in a dose-dependent manner [73]. Interestingly, the ethanolic extract of G. bimaculatus reduced lipopolysaccharides (LPS) or palmitate-induced ROS production in macrophages measured by the DCFDA assay [74]. The ethanolic extract also prevented alcohol-mediated 8-OHdG formation in mouse intestine [72].…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

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Road to The Red Carpet of Edible Crickets through Integration into the Human Food Chain with Biofunctions and Sustainability: A Review

Kemsawasd

Inthachat

Suttisansanee

et al. 2022

IJMS

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The Food and Agriculture Organization of the United Nations (FAO) estimates that more than 500 million people, especially in Asia and Africa, are suffering from malnutrition. Recently, livestock farming has increased to supply high-quality protein, with consequent impact on the global environment. Alternative food sources with high nutritive values that can substitute livestock demands are urgently required. Recently, edible crickets have been promoted by the FAO to ameliorate the food crisis. In this review, the distribution, nutritive values, health-promoting properties (antioxidant, anti-inflammatory, anti-diabetic and anti-obesity), safety, allergenicity as well as the potential hazards and risks for human consumption are summarized. Cricket farming may help to realize the United Nations sustainable development goal No. 2 Zero Hunger. The sustainability of cricket farming is also discussed in comparison with other livestock. The findings imply that edible crickets are safe for daily intake as a healthy alternative diet due to their high protein content and health-promoting properties. Appropriate use of edible crickets in the food and nutraceutical industries represents a global business potential. However, people who are allergic to shellfish should pay attention on cricket allergy. Thus, the objective of this review was to present in-depth and up-to-date information on edible crickets to advocate and enhance public perception of cricket-based food.

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Section: Anti-inflammatory Propertiesmentioning

confidence: 84%

Section: Antioxidant Activitiesmentioning

confidence: 99%

Road to The Red Carpet of Edible Crickets through Integration into the Human Food Chain with Biofunctions and Sustainability: A Review

Kemsawasd

Inthachat

Suttisansanee

et al. 2022

IJMS

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“…Due to inflammatory stimuli, the NLRP3 inflammasome is predominantly found in immune and inflammatory cells ( 13 , 14 ), and is equipped with NLRP3, the adaptor protein apoptosis-associated speck-like protein (ASC) and pro-caspase-1 ( 15 ). The NLRP3 protein comprises three main components, i.e., a leucine-rich repeat (LRR), a central nucleotide-binding oligomerization domain (NOD), also known as NACHT, in the carboxy terminus, and a pyrin domain (PYD) in the amino-terminal.…”

Section: Biology Of the Nlrp3 Inflammasomementioning

confidence: 99%

Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)

et al. 2023

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The inflammasome regulates innate immunity by serving as a signaling platform. The Nod-like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis-associated speck-like protein (ASC) and pro-caspase-1, is by far the most extensively studied and well-characterized inflammasome. A variety of stimuli can activate the NLRP3 inflammasome. When activated, the NLRP3 protein recruits the adaptor ASC protein and activates pro-caspase-1, resulting in inflammatory cytokine maturation and secretion, which is associated with inflammation and pyroptosis. However, the aberrant activation of the NLRP3 inflammasome has been linked to various inflammatory diseases, including atherosclerosis, ischemic stroke, Alzheimer's disease, diabetes mellitus and inflammatory bowel disease. Therefore, the NLRP3 inflammasome has emerged as a promising therapeutic target for inflammatory diseases. In the present review, systematic searches were performed using 'NLRP3 inhibitor(s)' and 'inflammatory disease(s)' as key words. By browsing the literature from 2012 to 2022, 100 articles were retrieved, of which 35 were excluded as they were reviews, editorials, retracted or unavailable online, and 65 articles were included. According to the retrieved literature, the current understanding of NLRP3 inflammasome pathway activation in inflammatory diseases was summarize, and inhibitors of the NLRP3 inflammasome pathway targeting the NLRP3 protein and other inflammasome components or products were highlighted. Additionally, the present review briefly discusses the current novel efforts in clinical research.

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“…To confirm the toxicity of the mealworm samples before measuring the expression of cytokine and myostatin, cell viability tests were carried out using the 3-(4,5-dimethylazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. 24 C2C12 mouse skeletal muscle cells were seeded in a 96-well plate at densities of 5 × 10 4 and 1 × 10 5 cells/well and incubated for 24 h at 37 °C, after which each sample was equally added to the wells at concentrations of 0−2000 and 10−1000 μg/mL, respectively, and then further incubated at 37 °C for 24 h. After incubation, 10 μL of MTT reagent (0.5 mg/mL final concentration) was added to each well and incubated at 37 °C for 2 and 4 h, respectively. Next, all the liquid in the wells was aspirated, 50 μL of DMSO was added to the wells, the reaction occurred for 30 min, and the absorbance was measured at 540 nm using a microplate spectrophotometer (Epoch, BioTek, Winooski, VT).…”

Section: Degree Of Hydrolysis and Sds-pagementioning

confidence: 99%

Effects of Enzymatic Hydrolysis and Size Fractionation of Mealworm (Tenebrio molitor larvae) Protein on Antioxidant and Anti-Inflammatory Activities and Inhibition of Muscle Loss

Yoon

Park

et al. 2023

ACS Food Sci. Technol.

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The antioxidant, anti-inflammatory, and muscle loss inhibitory effects of mealworm protein were investigated. Mealworm protein hydrolysate (MPH) was obtained by enzymatic hydrolysis and fractionated based on the molecular size. Although the protein content decreased with hydrolysis, it increased with an increase in size. Upon hydrolysis, essential and branched-chain amino acids decreased while free amino acids increased but decreased with an increase in size. The antioxidant activity increased upon hydrolysis and with an increase in molecular size. The anti-inflammatory effects were highest for MPH > 10 kDa and were similar to whey protein isolate (WPI), for IL-1β, IL-6, and TNF-α. Size fractionation did not significantly affect the anti-inflammatory effects. The MPH > 10 kDa (1.19-fold of control) resulted in the lowest myostatin expression in C2C12 muscle cells with and without LPS, which was similar to WPI (1.23-fold). Consequently, MPH may be a potential alternative to WPI.

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Gryllus bimaculatus extract protects against lipopolysaccharide and palmitate-induced production of proinflammatory cytokines and inflammasome formation

Cited by 17 publications

References 41 publications

Road to The Red Carpet of Edible Crickets through Integration into the Human Food Chain with Biofunctions and Sustainability: A Review

Road to The Red Carpet of Edible Crickets through Integration into the Human Food Chain with Biofunctions and Sustainability: A Review

Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)

Effects of Enzymatic Hydrolysis and Size Fractionation of Mealworm (Tenebrio molitor larvae) Protein on Antioxidant and Anti-Inflammatory Activities and Inhibition of Muscle Loss

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