<i>GSTM1</i> and <i>GSTT1</i> Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

Guo, Xiuchan; O’Brien, Stephen J.; Zeng, Yi Xin; Nelson, George W.; Winkler, Cheryl A.

doi:10.1158/1055-9965.epi-08-0149

Cited by 40 publications

(28 citation statements)

References 19 publications

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“…Subsequent to performing a careful search, 322 potentially relevant publications were identified. Based on the inclusion criteria, 8 studies (5 for p53 and 3 for GSTM1) (25)(26)(27)(28)(29)(30)(31)(32) were eligible for this meta-analysis. A flow diagram describing the selection process for the eligible studies is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Association of the p53 or GSTM1 polymorphism with the risk of nasopharyngeal carcinoma: A meta-analysis

Wu¹,

Huang

Liu

et al. 2015

Molecular and Clinical Oncology

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Abstract. p53 and glutathione S-transferase M1 (GSTM1) are the most popular suppressor genes. Several previous studies demonstrated positive associations of these gene polymorphisms with numerous cancer types, including hepatocellular cancer, while the association between p53/GSTM1 polymorphisms and the nasopharyngeal carcinoma (NPC) risk was inconsistent and underpowered. However, no studies investigating the combinational effect of these two genes on NPC risk were performed. To confirm the effects of p53 and GSTM1 polymorphisms on the risk of NPC, a meta-analysis of all the available previous studies associating p53 and GSTM1 with the risk of NPC was performed. A comprehensive search of PubMed, Web of Science and SD database until November 2014 was performed to identify the relevant studies. The data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. Finally, five studies with 1,419 cases and 1,707 controls were included for the p53 polymorphism and three studies with 837 cases and 1,299 controls were included for the GSTM1 polymorphism. Regarding p53, a significantly increased NPC risk was observed in the overall population (C vs. G, OR, 1.245; 95% CI, 1.045-1.483; P=0.014; additive models: CC vs. GG, OR, 1.579; 95% CI, 1.100-2.265; P=0.013 and CG vs. GG, OR, 1.230; 95% CI, 1.039-1.456; P=0.016; dominant model, OR, 1.321; 95% CI, 1.127-1.549; P=0.001; recessive model, OR, 1.429; 95% CI, 1.017-2.009; P=0.040). Concerning GSTM1, a significantly increased NPC risk was observed in the overall population (null versus non-null, OR, 1.282; 95% CI, 1.075-1.530; P=0.006). In the subgroup analyses stratified by the source of controls, a significant association of p53 with NPC risk was also demonstrated, while no association with GSTM1 was observed. Therefore, the p53 G72C polymorphism may have a susceptible role in the carcinogenesis of NPC, while genetic deletion of GSTM1 may contribute to increased susceptibility to NPC. Further large and well-designed studies are required to confirm this association.

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Section: Resultsmentioning

confidence: 99%

“…In the case of the assessment of the quality of the included studies, as shown in Table II, 2 were identified as 'low quality' (25,26), and 3 were identified as 'high quality' (27)(28)(29). As shown in Table III, all the studies were identified as 'high quality' (30)(31)(32) Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

Association of the p53 or GSTM1 polymorphism with the risk of nasopharyngeal carcinoma: A meta-analysis

Wu¹,

Huang

Liu

et al. 2015

Molecular and Clinical Oncology

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“…Similarly, there was no association between this type of neoplasia and the null combined genotypes null GSTT1 and null GSTM1, as observed by Singh et al 7 On the other hand, a Chinese study has shown a correlation between the double null genotype GSTT1 and GSTM1 with nasopharynx cancer among men. 44 With respect to the relation between genes deletion and specific anatomic sites, Duarte et al 25 found an association between the GSTM1 null genotype and the increase in risk of development of leukoplasia in the oral cavity. On the other hand, in our study we have identified a relation between the occurrence of larynx carcinoma with GSTT1 null genotype and, on the contrary, a protective effect of this genotype in the pharynx.…”

Section: Discussionmentioning

confidence: 99%

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Leme¹,

Raposo²,

Ruiz³

et al. 2010

Rev. Assoc. Med. Bras.

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Objective. To establish the clinical and demographic profile and identify risk factors among patients with head and neck cancer, relating them to the polymorphism of GSTT1 and GSTM1. MethOds. One hundred patients with head and neck cancer and 100 control group individuals without history of neoplasm were analyzed. The molecular analysis was made by multiplex polymerase chain reaction. For statistical analysis, data were tabulated and compared by the Fisher's exact test, the Chi-square test and multiple logistic regression were also used.Results. There was prevalence of smokers (OR = 5.32, CI 95% CI = 2.04-13.86 p = 0.0006), alcohol drinkers (OR = 5.04, CI 95% = 2.19-11.59 p = 0.0001) in head and neck cancer patients. The GSTT1 null genotype was found in 47% of the patient and 41% of the control group (OR = 0.67; CI 95%= 0.34-1.35; p = 0.2648). Likewise, the GSTM1 null genotype was found in 66% of the patient and 75% of the control group (OR = 2.25; CI 95%= 1.05 -4.84; p = 0.0368). The combined GSTT1 and GSTM1 gene null genotype shown association between GSTM1*0/GSTT1 and occurrence of head and neck carcinoma (OR = 7.64; CI 95%= 1.72-34.04; p = 0.0076). Analysis of clinical-pathological features showed association between GSTT1 null genotype and larynx, the inverse relation between this genotype and pharynx. cOnclusiOn. In our study it was possible to establish an association between the nullity of GSTM1 genotype and that of combined GSTT1/GSTM1*O ([]/ [-] genotypes and head and neck cancer. gstM1 and gstt1 genes analysis in head and neck canceR patients cássia veRidiana dOuRadO leMe 1 , luis séRgiO RapOsO 2 , MaRiangela tORReglOsa Ruiz 3 , jOice MatOs biselli 4 , ana lívia silva galbiatti 5 , jOsé victOR Maniglia 6 , éRika cRistina pavaRinO-beRtelli 7 , eny MaRia gOlOni-beRtOllO 8*

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“…However, the distribution of this cancer is highly skewed, the highest incidence rates seen in China and Southeast Asian region (Cheng et al, 2003). The NPC is most prevalent in Chinese and Malaya population and is a leading cause of death among Cantonese in Southern China (Guo et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Besides, Chinese foods such as salt-cured fish and smoke-dried meat which while cooking aerosolize carcinogenic nitrosamines that are subsequently inhaled may also pose a risk of developing NPC (Guo et al, 2003). Despite many individuals being exposed to these risk factors, only a minority of them develop NPC.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of GSTM1 and GSTT1 Polymorphisms and Risk of Nasopharyngeal Cancer

Murthy¹,

Kumar²,

Suresh³

2013

Asian Pacific Journal of Cancer Prevention

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Background: Studies of associations between genetic polymorphism of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) with risk of nasopharyngeal cancer (NPC) have generated conflicting results. Thus, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on the risk of developing NPC. Materials and Methods: A literature search in two electronic databases namely PubMed and EMBASE up to December 2012 was conducted and eligible papers were finally selected based on the inclusion and exclusion criteria. The pooled odds ratio (OR) and presence of heterogeneity and publication bias in those studies were evaluated. Results: A total of 9 studies concerning nasopharyngeal cancer were evaluated. Analyses of all relevant studies showed increased NPC risk to be significantly associated with the null genotypes of GSTMI (OR=1.43, 95%CI 1.24-1.66) and GSTT1 (OR=1.28, 95%CI=1.09-1.51). In addition, evidence of publication bias was detected among the studies on GSTM1 polymorphism. Conclusions: This meta-analysis demonstrated the GSTM1 and GSTT1 null genotypes are associated with an increased risk of NPC.

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GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

Cited by 40 publications

References 19 publications

Association of the p53 or GSTM1 polymorphism with the risk of nasopharyngeal carcinoma: A meta-analysis

Association of the p53 or GSTM1 polymorphism with the risk of nasopharyngeal carcinoma: A meta-analysis

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Meta-analysis of GSTM1 and GSTT1 Polymorphisms and Risk of Nasopharyngeal Cancer

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