GSTM1, GSTP1, and GSTT1 genetic variability in <scp>T</scp>urkish and worldwide populations

Karaca, Sefayet; Karaca, Mehmet; Cesuroğlu, Tomris; Erge, Sema; Polimanti, Renato

doi:10.1002/ajhb.22671

Cited by 25 publications

(11 citation statements)

References 48 publications

(50 reference statements)

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“…The present study revealed that the frequency of GSTT1 null genotype is (20.4%), this frequency is higher than those reported in a previous case control study that was performed by Al-Awadiy et al (22) in the Iraqi population, which was (6.9%). The GSTT1 null genotype frequency was similar to Caucasian (19.7%) and concordant with those documented for Turkish (23%) population and was lower than that reported in Arab (37.1%) and African (26%) population (25,30) (table 1). The GSTM1 null genotype frequency (66.2%) reported in the current study was comparable to that observed in Asians and Caucasians (40-62%) (23) but higher than that observed in African (26.7%) The proportion of double nulls (GSTM1 and GSTT1 null genotypes), synonymous of absence of enzyme activity in the sample study (12%) was concordant to that previously reported by Al-Awadi et al (22) for the Iraqi population(10%) as well as for other Arab populations, including Bahraini (14.4%); Lebanese (16.3%) population; and it is nearly similar to that of the Caucasians and African population and less than that observed in Arabs (Saudi) population (24,25) .…”

Section: Discussionsupporting

confidence: 88%

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Baghdad Population

2016

IJMS

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Background Glutathione S-transferases (GSTs) are enzymes of Phase II, which play an important role in cellular detoxification by conjugation of reduced glutathione with a wide variety of potentially toxic and carcinogenic. Polymorphisms of genes coding for the glutathione S-transferase (GST) enzymes were known to be associated with susceptibility to various forms of cancer, or outcome of multichemotherapeutic regimens. Objective To analyze of the frequencies of the major polymorphisms of the GSTM1 and GSTT1 in Baghdad population to provide a basic database for future genetic and clinical studies. Methods Peripheral blood was obtained from 142 healthy individuals randomly selected from two districts in Baghdad. The age of studied participants ranges from 15-46 yeares at time of inclusion. Genomic DNA was isolated from leukocytes using Wizerd genomic DNA purification kit. The GSTT1 and GSTM1 gene polymorphism were evaluated using multiplex polymerease chain reaction in which albumen gene was used as internal controls. Results Twenty nine individuals (20.4%) revealed no amplification of the GSTT1 gene (null type). The null GSTM1 genotype was found in 66.2% (94 individuals). Twelve percent (17/142) had null genotype for both genes. The most frequently observed genotype was GSTT1 positive/GSTM1 null genotype (54.2%) while the GSTT1 null/GSTM1 positive genotype observed in 12 individuals (8.5%). GSTT1postive/GSTM1 positive genotype was found in 36 (25.4%) of the sample study. Conclusion Data of the present study showed that the frequency of GSTT1 and GSTM1null genotype of the sample study is in concordance with those documented for Caucasian, Asians, and Arabs population. This study provides information for frequency distribution of GSTT1and GSTM1 null genotypes in the Baghdad population and information about genetic difference between Iraqi individuals and other population that provide basis for future genetics and clinical studies.

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Section: Discussionsupporting

confidence: 88%

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Baghdad Population

2016

IJMS

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“…The results in our control population were similar to those that are found in Caucasians and the Turkish population that were found in other studies. In a recent study that was performed in the Turkish population, by Karaca et al (2015) , it was reported that the frequencies of the null genotype of the GSTM1 and the GSTT1 genes were 52% and 23%, respectively, and the frequency of the Val105 allele of the GSTP1 was 29%.…”

Section: Discussionmentioning

confidence: 99%

Role of glutathione S-transferase M1, T1 and P1 gene polymorphisms in childhood acute lymphoblastic leukemia susceptibility in a Turkish population

et al. 2015

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The variations between different individuals in the xenobiotic metabolizing enzymes' activity were shown to modify susceptibility to childhood acute lymphoblastic leukemia (ALL). Polymorphisms associated with genes coding for the glutathione S-transferase (GST) enzyme were known to affect the metabolism of different carcinogens. The aim of this study was to evaluate the influence of the GSTM1 and GSTT1 deletion polymorphisms, and the GSTP1 Ile105Val single nucleotide polymorphism (SNP) on the susceptibility to childhood ALL. The study was conducted in 95 children with ALL and 190 healthy control subjects from the Turkish population. The data revealed no difference in the prevalence of the GSTM1 and GSTT1 null genotypes between the childhood ALL patients and the controls. No association was found between GSTP1 Ile105Val variants and the susceptibility to childhood ALL, separately or in combination. Our findings suggested that the status of heritable GST polymorphism might not influence the risk of developing childhood ALL. Studies with a larger sample size are needed to evaluate and confirm the validity of our results.

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“…All laboratory procedures were performed according to the manufacturer's protocol of the MassArray platform (Sequenom Inc., CA, USA). Detailed information about the genotyping pipeline is reported in our previous study [22].…”

Section: Genotypingmentioning

confidence: 99%

“…The genetic background of the Turkish population is an admixture of European, Middle Eastern and Central Asian ancestries [21]. Although Turkish people share a relevant percentage of their genetic background with Europeans, significant differences are present between Turkish and North European populations, partially explaining the health disparities of Turkish communities in Northern Europe [22,23]. To our knowledge, three previous studies investigated the impact of VKORC1 and CYP2C9 polymorphisms on warfarin dosing in the Turkish populations [24][25][26].…”

Section: Introductionmentioning

confidence: 96%

International Warfarin Genotype-Guided Dosing Algorithms in the Turkish Population and Their Preventive Effects on Major and Life-Threatening Hemorrhagic Events

Karaca

Bozkurt

Cesuroğlu³

et al. 2015

Pharmacogenomics

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GSTM1, GSTP1, and GSTT1 genetic variability in Turkish and worldwide populations

Cited by 25 publications

References 48 publications

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Baghdad Population

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Baghdad Population

Role of glutathione S-transferase M1, T1 and P1 gene polymorphisms in childhood acute lymphoblastic leukemia susceptibility in a Turkish population

International Warfarin Genotype-Guided Dosing Algorithms in the Turkish Population and Their Preventive Effects on Major and Life-Threatening Hemorrhagic Events

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