<i>Hafnia alvei</i> pyelonephritis in a renal transplant recipient: case report and review of an under‐recognized nosocomial pathogen

Cardile, Anthony P.; Forbes, Diane; Cirigliano, Vito; Stout, B.; Das, Nabamita; Hsue, Günther

doi:10.1111/j.1399-3062.2011.00600.x

Cited by 13 publications

(9 citation statements)

References 12 publications

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“…According to the microbial polysaccharide database ( 1 ), α-linked mannose containing O-antigens are found in various Gram-negative bacterial species, such as Citrobacter braakii ; Citrobacter werkmanii O21 ( 22 , 23 ); Escherichia coli O8, O9, O68, and K12 ( 24 – 27 ); K. pneumoniae O3 and O5 ( 24 , 25 ); Hafnia alvei PCM 1223 ( 28 ); and Serratia marcescens O28 ( 29 ). Some of these bacteria can cause nosocomial infections in lung and urinary tract ( 30 – 34 ). Of note, 11% of K. pneumoniae clinical isolates were shown to be serotype O3 and O5 ( 35 ).…”

Section: Introductionmentioning

confidence: 99%

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

Wittmann

Lamprinaki

Bowles

et al. 2016

Journal of Biological Chemistry

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LPS consists of a relatively conserved region of lipid A and core oligosaccharide and a highly variable region of O-antigen polysaccharide. Whereas lipid A is known to bind to the Toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex, the role of the O-antigen remains unclear. Here we report a novel molecular interaction between dendritic cell-associated C-type lectin-2 (Dectin-2) and mannosylated O-antigen found in a human opportunistic pathogen, Hafnia alvei PCM 1223, which has a repeating unit of [-Man-α1,3-Man-α1,2-Man-α1,2-Man-α1,2-Man-α1,3-]. H. alvei LPS induced higher levels of TNFα and IL-10 from mouse bone marrow-derived dendritic cells (BM-DCs), when compared with Salmonella enterica O66 LPS, which has a repeat of [-Gal-α1,6-Gal-α1,4-[Glc-β1,3]GalNAc-α1,3-GalNAc-β1,3-]. In a cell-based reporter assay, Dectin-2 was shown to recognize H. alvei LPS. This binding was inhibited by mannosidase treatment of H. alvei LPS and by mutations in the carbohydrate-binding domain of Dectin-2, demonstrating that H. alvei LPS is a novel glycan ligand of Dectin-2. The enhanced cytokine production by H. alvei LPS was Dectin-2-dependent, because Dectin-2 knock-out BM-DCs failed to do so. This receptor cross-talk between Dectin-2 and TLR4 involved events including spleen tyrosine kinase (Syk) activation and receptor juxtaposition. Furthermore, another mannosylated LPS from Escherichia coli O9a also bound to Dectin-2 and augmented TLR4 activation of BM-DCs. Taken together, these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 responses through interaction with Dectin-2.

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Section: Introductionmentioning

confidence: 99%

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

Wittmann

Lamprinaki

Bowles

et al. 2016

Journal of Biological Chemistry

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“…Other case reports on clinical infection caused by Hafnia alvei exist and include pyelonephritis in renal transplant, pediatric cardiac surgery, and nosocomial pneumonia [9] , [12] , [13] , [14] . There is a single case of a wound infection caused purely by Hafnia alvei developing in an abscess at the site of puncture by a nail gun [15] .…”

Section: Discussionmentioning

confidence: 99%

Hafnia alvei : A new pathogen in open fractures

Litrenta

Oetgen

2017

Trauma Case Reports

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BackgroundDeep infection following open both bone forearm fractures is a rare complication. Prophylactic antibiotic regimens are targeted at the most common pathogens, which include primarily Staph aureus followed by gram-negative bacteria. Hafnia alvei is an unusual pathogen that is rarely pathogenic in humans and has never been reported as a cause of infection following open fracture.MethodsWe present a 12-year-old male with an open forearm fracture who developed a late deep infection. Cultures grew only Hafnia alvei. The patient was treated with debridement, placement of antibiotic beads, and ciprofloxacin.ResultsAt 6 months following the initial debridement, the patient had no clinical evidence of infection and regained full function of the affected forearm without any residual deficits.ConclusionsThis is the first report of deep infection following an open forearm fracture owing to Hafnia alvei, a pathogen rarely responsible for human infection.

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“…As pathogen, humans have generally been considered an opportunistic bacteria, and may cause infections associated to underlying illnesses or predisposing factors as immunocompromised patients (Sakazaki & Tamura 1992), causing septicaemia (Englund 1969;Ginsberg & Goldsmith 1988;Fazal et al 1997;Liu et al 2007), endocarditis (Gallego et al 1999;Loulergue et al 2007), meningitis (Mojtabaee & Siadati 1978), pneumonia (Klapholz et al 1994;Fazal et al 1997), abscesses (Agustin & Cunha 1995), urinary infections (Sakazaki & Tamura 1992;Krieg & Sneath 1994;Ramos & Dámaso 2000;Cardile et al 2011), peritonitis (Jung et al 2010;Yap et al 2010), endophthalmitis (Ruiz-Moreno et al 2001), cholecystitis (Palaniswamy et al 2009), intestinal disorders (Harada et al 1957;Emslie-Smith 1961;Ratnam 1991;Westblom & Milligan 1992;Reina et al 1993;Ridell et al 1994) and postenteritic arthritis (Newmark et al 1994).…”

Section: H Alvei In Human Medicinementioning

confidence: 99%

The pathogenHafnia alveiin veterinary medicine: a review

Padilla

Acosta

Ramos-Vivas

et al. 2014

Journal of Applied Animal Research

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Hafnia alvei is a Gram negative bacterium that belongs to the family Enterobacteriaceae. It is part of the intestinal flora of humans and animals, moreover it has been described from natural environments and foodstuffs. In human medicine is considered an opportunistic bacterium that causes different infections associated to underlying illnesses or predisposing factors as immunocompromised patients. The knowledge and literature about this bacterium in veterinary medicine is scarce, highlighting its importance in gastropods and bees, and it has also been described in poultry, mares, fish and ruminants producing various clinicopathologic signs.

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Hafnia alvei pyelonephritis in a renal transplant recipient: case report and review of an under‐recognized nosocomial pathogen

Abstract: We describe the first case to our knowledge of Hafnia alvei pyelonephritis in a renal transplant recipient. Clinicians should consider this under-recognized pathogen when clinically evaluating immunosuppressed patients with a history of invasive procedures.

Cited by 13 publications

References 12 publications

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

Hafnia alvei : A new pathogen in open fractures

The pathogenHafnia alveiin veterinary medicine: a review

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