Has-mir-146a rs2910164 polymorphism and risk of immune thrombocytopenia

Abstract

The purpose of this study was to determine the association of single nucleotide polymorphisms (SNP) of the has-mir-146a (miR-146a) genes with the risk for immune thrombocytopenia (ITP). The genotyping of miR-146a rs2910164 polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism. In the patients with ITP, the frequencies of GG, GC and CC genotypes and G and C alleles were 12.5%, 47.9%, 39.6%, 36.4% and 63.6%, respectively. There was no significant difference in genotype and alleles distribution between the ITP patient and the controls (p = 0.77 and 0.51, respectively). No significant differences were found between the two groups when stratified by the age and disease course including acute adult, chronic adult, acute childhood and chronic childhood. In conclusion, there was no association between the SNP of miR-146a and the susceptibility to ITP in a Chinese population.

Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms

“…SNPs in the miR gene region may directly affect the expression of the mature miRNA, resulting in diverse functional consequences. To date, various epidemiological studies have indicated associations between SNPs in miRNAs and cancer susceptibility [ 3 ], autoimmune diseases [ 8 , 14 ], schizophrenia [ 22 ] and cardiovascular disease [ 19 , 23 ].…”

“…Over the past several years, it has become increasingly clear that miRNAs are not only important for normal organismal development and physiology but also in the pathologies of autoimmune diseases, cancer, heart disease, and inflammation [ 5 – 7 ]. Regarding autoimmune diseases, it has been reported that many have similar underlying etiology and have shared susceptible genes [ 8 ]. Among all the miRNAs discovered, miR-146a and miR-499 have been received much attention in this field.…”

“…The common miR-146a polymorphism rs2910164 involves a G>C nucleotide replacement. It can lead to the change from a G:U pair to a C:U mismatch in the stem structure of the miR-146a precursor [ 8 ]. The miR-499 rs3746444T>C polymorphism has been found within the stem region of the miR-499 gene and results in an A:U to G:U mismatch in the stem structure of the miR-499 precursor [ 3 ].…”