Helicobacter pylori and Nonmalignant Diseases

Abstract

The incidence of peptic ulcer disease has declined over the last few decades, particularly in Western populations, most likely as a result of the decrease in Helicobacter pylori infection and the widespread use of proton-pump inhibitors (PPI) in patients with dyspepsia. The hospital admission rate for uncomplicated duodenal and gastric ulcers has significantly decreased worldwide. In contrast, admissions for complicated ulcer disease, such as bleeding peptic ulcers and perforation, remained relatively stable. Prophylactic H. pylori eradication was found to be associated with a reduced risk of both gastric and duodenal ulcers and their complications, including bleeding in chronic users of nonsteroidal anti-inflammatory drugs. The recent Helicobacter Eradication Relief of Dyspeptic Symptoms trial presented important data relating to symptoms and quality of life of H. pylori-positive patients with functional dyspepsia (FD) and also demonstrated significant benefits from eradication compared with the control group. The new Asian consensus report on FD recommended that dyspepsia accompanied by H. pylori infection should be considered a separate disease entity from FD and that H. pylori infection should be eradicated before diagnosing FD. The association of H. pylori with gastroesophageal reflux disease (GERD) is still controversial. Treatment for H. pylori does not seem to increase GERD symptoms or reflux esophagitis. However, documented eradication of H. pylori appears to significantly improve GERD symptoms. Additional long-term intervention studies are needed to provide more information on which to base clinical decisions.

Comparison Between 10‐ and 14‐Day Hybrid Regimens for Helicobacter pylori Eradication: A Randomized Clinical Trial

“…The global prevalence of Helicobacter pylori infection is more than 50%. H. pylori infection is associated with peptic ulcer disease, gastric cancer, and mucosa-associated lymphoid tissue lymphoma [1,2]. Therefore, H. pylori eradication has always been a concern.…”

Clinical and Endoscopic Features in Helicobacter Pylori Infection: Literature Review

“…55,56 The relationship between GERD and H.pylori is still controversial. 26,43,57 Most of the studies conducted showed negative results between the relationship between H.pylori and GERD. 43 In several studies, it is stated that H.pylori infection can protect against GERD.…”

Down-Regulation of miR-141 Induced by Helicobacter Pylori Promotes the Invasion of Gastric Cancer by Targeting STAT4

“…Recently, H. pylori infection rate is increasing, especially in developing countries [11]. Clinical evidence suggested that H. pylori is related to gastric cancer, but the mechanism remained unclear [12].…”