<i>Helicobacter pylori</i>: association with gall bladder disorders in Pakistan

Yakoob, Javed; Khan, Muhammad Rizwan; Abbas, Zaigham; Jafri, W.; Azmi, Rizwan; Ahmad, Zubair; Naeem, Syed; Lubbad, Loay

doi:10.1080/09674845.2011.11730324

Cited by 26 publications

(25 citation statements)

References 24 publications

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“…The strategy of study selection is displayed in Figure S1. Eighteen case-control studies published between 1998 and 2011 were finally eligible for meta-analysis (Table 1) [8], [9], [22]–[37]. These studies involved 1678 patients with a total Helicobacter sp.…”

Section: Resultsmentioning

confidence: 99%

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

et al. 2011

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BackgroundSince the isolation of Helicobacter species in biliary system, a hypothetical question was raised about the role of these agents in the development of cholelithiasis. This meta-analysis is to explore the association between the Helicobacter infection and biliary lithiasis.Methodology/Principal FindingsA systematic literature search was performed to identify all eligible articles. Meta-analysis which was carried out using odds ratio and random effect model, 95% confidence intervals for odds ratio was calculated. Quantitative assessment of heterogeneity was explored by chi-square test with significance set at P value 0.10 and was measured using I 2 statistic. Eighteen studies published between 1998 and 2011 were finally eligible for meta-analysis. H. Pylori, H. Bilis, H. Hepaticus, H. Pullorum and H. Ganmani were studied. With heterogeneity (I2 = 69.5%, P<0.0001), significantly higher pooled infection rates of H. Pylori (OR: 2.59, 35.82% versus 26.75%, P = 0.01) and H. Hepaticus (OR: 3.13, 31.30% versus 12.12%, P = 0.02) were observed in lithiasis group. Higher prevalence of H. Pylori in cholelithiasis patients were reported by studies from East Asia, South Asia and South America. Evidences supporting the higher presence of H. Pylori in cholelithiasis patients could be found by PCR for detecting 16s rRNA in bile, 26kDa protein gene in biliary tissue and immunohistochemistry. Using multiple detection tests could increase the detection rate of H. Pylori.Conclusions/SignificancesOur meta-analysis suggests a trend of higher presence of H. Pylori in cholelithiasis patients than control group and this trend was significant in the regions with higher prevalence of this agent. Evidences supporting the association between Helicobacter and cholelithiasis could be found by using different tests but the gold standard for the identification of these bacteria in biliary system has yet to be established. Considering obvious heterogeneity, a large multi-center study will facilitate us to further clarify the association between the Helicobacter infection and cholelithiasis.

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Section: Resultsmentioning

confidence: 99%

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

et al. 2011

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“…Helaly and colleagues showed that H. pylori is present in almost 40.9% of samples in patients with chronic calcular cholecystitis [23]. Similarly, Yakooband and colleagues demonstrated that 22 (25%) patients in case group and 5 (9%) in controls were positive for H. pylori [20]. Other findings were also indicative of the positive association between H. pylori infection and cholecystitis, where the association varied from 7% to more than 55% [21,22].…”

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confidence: 82%

“…But the results are contradictory. Some studies clearly show a significant association between positive H. pylori test in the stomach and the presence of stones in the gallbladder [20][21][22]. Studies also suggest that infection by this organism in the gallbladder can be considered as an etiologic factor in the formation of gallstones, especially pigment stones [23].…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Cholecystitis and Presence of Helicobacter pylori in the Gallbladder

Motie

Rezapanah

Abbasi

et al. 2017

Zahedan J Res Med Sci

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Background: As there is an established relationship between Helicobacter pylori infection and gastric and duodenal ulcers, there might also be a relationship between this infection and other pathologies of gastrointestinal system. Objectives: Thus in this study we decided to investigate the relationship between H. pylori infection and cholecystitis. Methods: In this case-control study, patients were divided into two groups: case group with cholecystitis or cholelithiasis and controls with normal gallbladder. In both groups, after removal of the gallbladder, the samples were sent to the pathology laboratory for further evaluation. The presence of H. pylori gene in gallbladder tissue was determined by PCR (Polymerase chain reaction), and the results were compared between the groups.

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“…Demonstration of Helicobacter in gallbladder tissue histology varies 40 from 0 % to 28 % [1][2][3][4][5][6]. BostanoAylu et al [1] could not culture Helicobacter in any of their 47 patients with gallstone disease and 30 controls.…”

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confidence: 99%

“…Indirect evidence of H. pylori in gallbladder by demonstration of DNA of different components of bacillus is found in 7 % to 61.5 % tissue examined [2][3][4][5][6][7][8][9][10].…”

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confidence: 99%

Discovery of Helicobacter pylori in gallbladder

Shukla

Tewari

2012

Indian J Gastroenterol

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Helicobacter pylori, a gramnegative and microaerophilic organism, is transmitted from person-to-person through the feco-oral route and colonizes the stomach. The organism persists in the healthy host in equilibrium, which is disturbed at times, leading to formation of peptic ulcer and gastric cancer. Presence of H. pylori in the biliary tree of a small proportion of individuals has led to the conjecture that it is a potential cause of gallbladder disease. The exact pathway of how the organism reaches the gallbladder is unclear. It could reach the gallbladder directly from the stomach or through the portal blood circulation. In contrast to the stomach, colonization of the gallbladder is unlikely due to the alkaline pH of bile, H. pylori being known to thrive at the low pH of gastric juice.There are several tests to confirm presence of H. pylori in the stomach. These include rapid urease test, and demonstration of the bacterium on histology and culture of gastric biopsy, and positive urea breath ( 13 C or 14 C) test. Molecular tests identify the genes of H. pylori in the tissue. Immunological evidence of H. pylori infection is provided by presence of H. pylori-specific IgG and IgM antibodies in the blood. Similar tests can be used to demonstrate H. pylori in gallbladder and bile.Demonstration of H. pylori in gallbladder has been attempted directly by culture of gallbladder, bile or gallbladder mucosal scrappings or demonstration of the bacillus on histology of gallbladder. Indirect evidence of H. pylori in gallbladder by demonstration of DNA of different components of bacillus is found in 7 % to 61.5 % tissue examined [2][3][4][5][6][7][8][9][10].Evidence of immunological response to Helicobacter is often positive in patients with gallbladder disease. Antibodies to Helicobacter have been reported in 18 % to 80 % of patients with gallstone disease [2,[11][12][13], 32 % to 38.8 % of cancer gallbladder [2, 11] and 13.1 % to 47.5 % of controls [11,13]. However, serology is not specific for Helicobacter infection of the gallbladder. It is a systemic effect of Helicobacter infection anywhere in the body.In this issue of the Journal, Bansal et al.[12] demonstrate the presence of H. pylori DNA in 32.6 % of 49 gallbladders surgically removed for benign biliary disease. None of these gallbladders showed H. pylori organisms on histology, even when special stains were used. DNA detection by PCR is very sensitive. Helicobacter genus (total 32 species) in general and H. pylori specifically are detected by an array of PCR tests using 26KDA, HSP60, Flagellin gene and other primers with varying sensitivities. The accuracy of the 26KDa primer is 9.3 % compared to that of 11.6 % using the Ure A gene on the same samples. Mishra and others [2] recently reported that 42.5 % of gallbladder carcinoma tissues were positive for the HSP60 gene. Bansal et al. [12] based the PCR on the UreA gene of H. pylori. However, it has been shown that this gene shares homology

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Helicobacter pylori: association with gall bladder disorders in Pakistan

Cited by 26 publications

References 24 publications

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

The Relationship Between Cholecystitis and Presence of Helicobacter pylori in the Gallbladder

Discovery of Helicobacter pylori in gallbladder

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