<i>Helicobacter pylori</i> eradication improves glycemic control in type 2 diabetes patients with asymptomatic active <i>Helicobacter pylori</i> infection

Cheng, Kai Pi; Yang, Yao; Hung, Hao Chang; Lin, Ching Han; Wu, Chung Tai; Hung, Mei Hui; Sheu, Bor Shyang; Ou, Horng Yih

doi:10.1111/jdi.12991

Cited by 29 publications

(33 citation statements)

References 45 publications

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“…12,13 Few studies have reported no such association. 14,15 According to this study, it was observed that H. pylori infection was commonly seen among type 2 diabetic group (79%) in comparison to non-diabetic group (21%). A significant association implied that there stands an association between H. pylori infection and diabetes.…”

Section: Discussionmentioning

confidence: 72%

Helicobacter pylori infection among type 2 diabetics: a case control study

et al. 2020

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Background: Helicobacter pylori infection has been associated with hyperglycemia among type 2 diabetics. The objective of this study was to compare the H. pylori infection frequency in diabetic and non-diabetic patients.Methods: This case-control study was done at Al-Tibri Medical College and Hospital from May 2019 to August 2019. After written and informed consent, patients between 18-75 years with epigastric burning, dyspepsia, regurgitation were included and with history of eradication therapy, antibiotic or NSAID use in the last 6 months or surgery of upper GI tract months were excluded. Type 2 diabetics were placed in one group and non-diabetic individuals in another. Both groups were compared for presence of H. pylori infection. Data was analysed using SPSS. Demographic variables included age, gender and status of H. pylori infection. Quantitative data was expressed as frequency and percentages. Chi-square test was applied to test for significance keeping p-value of <0.05 statistically significant.Results: From 480 patients, 355 patients showed positive H. pylori, among them 282 were diabetic and 73 non-diabetic (p-value <0.001). Amongst the 355 diabetics, 55% were male Among 73 non-diabetics, 64% were male. All the patients in the study had dyspeptic symptoms and complained of dyspepsia, epigastric burning and regurgitation.Conclusions: A substantial relationship between H. pylori infection among type 2 diabetes mellitus patients was observed compared to non-diabetics. As a result, diabetic patients having active dyspeptic symptoms should undergo further confirmatory tests for diagnosing H. pylori infection.

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Section: Discussionmentioning

confidence: 72%

Helicobacter pylori infection among type 2 diabetics: a case control study

et al. 2020

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“…This is consistent with the previously reported studies. [ 4 5 6 7 8 9 10 16 17 18 19 20 21 ] Most recently, a meta-analysis suggested a trend toward more frequent H. pylori infections in T2DM patients. [ 3 ] Meanwhile, the impact of H. pylori and T2DM was explored in Bener et al .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection among type 2 diabetes mellitus

et al. 2020

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Background: Several conducted studies have reported a higher and more frequent Helicobacter pylori infection rate in type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the prevalence and its association between H. pylori infection and T2DM. Materials and Methods: A case and control study was conducted based on 529 T2DM patients and 529 control. H. pylori was assessed by Serum anti- H. pylori immunoglobulin G (IgG) and IgA. Furthermore, patients were investigated for fasting blood glucose (FBG) levels, glycosylated hemoglobin (HbA1c), serum cholesterol, and other biochemistry parameters. Results: The findings showed a positive significantly higher antibody titer for H. pylori infection (IgA > 250) in diabetic patients (50.7%) compared to controls (38.2%) ( P < 0.001). Similarly, H. pylori infection for IgG > 300 titer was higher in T2DM patients (73.5%) compared to controls 61.8%) ( P < 0.001). Further, the mean values were statistically significant diabetes with H. pylori infection for IgG > 300 titer and IgA > 250 titer, regarding Vitamin D, HbA1C ( P < 0.001), FBG, calcium, creatinine, total cholesterol, LHDL, triglyceride levels, uric acid, bilirubin, thyroid-stimulating hormone (TSH), and systolic and diastolic blood pressure. The diabetic patients showed higher prevalence rate of symptoms than controls included: hypertension (14.3%), vomiting (15.5%), muscular symptoms (35.2%), bloating/distension (13.2%), abdominal pain (17%), nausea (9.6%), anemia (17%), kidneys (20.8%), chronic bronchitis (14.7%), gastrointestinal (23.8%), and diarrhea (20.4%). Conclusions: The current study revealed that H. pylori infections were significantly higher in diabetic patients compared to controls. Furthermore, T2DM patients infected with H. pylori positive reported a higher prevalence rate of symptoms than H. pylori negative .

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“…12 Interestingly, in Japan, the risk of DM decreased from 1.36 (95% CI, 1.10-1.67) to 0.92 (95% CI, 0.79-1.07) after H pylori eradication, 13 concordant with the findings that H pylori eradication decreased HbA1c levels in diabetic patients. 14…”

Section: Diabetesmentioning

confidence: 99%

Review: Extragastric diseases andHelicobacter pylori

et al. 2020

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The involvement of Helicobacter pylori infection in many extra‐gastroduodenal manifestations remains a fascinating field of investigation. However, for several of these supposed associations, the potential pathogenic mechanism remains unclear. The present review highlights the main associations of H pylori with extra‐gastroduodenal manifestations reported during the last year. We searched for the most relevant studies on this topic, published between April 2019 and March 2020, identified using the term “Helicobacter” in the MEDLINE/Pubmed database. Consistent data emerged from studies investigating metabolic syndrome and ischaemic cardiovascular diseases. Other reported fields of investigation were hepatology, especially focused on non‐alcoholic steatohepatitis, neurology, including Parkinson’s disease and Alzheimer’s disease, as well as dermatology. Inflammatory bowel disease (IBD), that comprises Crohn’s disease and ulcerative colitis, may originate from a dysregulation of the host’s immune response to commensal bacteria in individuals with genetic predisposition. The reduction of biodiversity and other specific imbalances in the faecal microbiome composition of IBD patients compared to that of healthy controls support this hypothesis. In this context, an inverse correlation between H pylori infection and IBD prevalence has been confirmed. Similar results were found in patients with kidney diseases and allergic manifestations. There are indications of the possible involvement of H pylori infection in metabolic syndrome and ischaemic cardiovascular diseases. However, due to a series of factors linked to study designs and the multifactorial pathogenesis of some diseases, further studies are needed.

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Helicobacter pylori eradication improves glycemic control in type 2 diabetes patients with asymptomatic active Helicobacter pylori infection

Cited by 29 publications

References 45 publications

Helicobacter pylori infection among type 2 diabetics: a case control study

Helicobacter pylori infection among type 2 diabetics: a case control study

Prevalence of Helicobacter pylori infection among type 2 diabetes mellitus

Review: Extragastric diseases andHelicobacter pylori

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