<i>Helicobacter pylori</i> eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study

Nam, Seung‐Joo; Park, Sung Chul; Lee, Sang Hoon; Choi, Dong Wook; Lee, Sung Joon; Bang, Chang Seok; Baik, Gwang Ho; Park, Jong Kyu

doi:10.1177/2050312119832093

Cited by 13 publications

(14 citation statements)

References 35 publications

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“…15,16 Other studies revealed disagreement in the prevalence between H. pylori infection in diabetics and non-diabetics 21.3% vs. 20.2%, 17 42.9% vs. 43.1%, 18 73.5% vs. 76.5%. 19 This study contradicts our results which may be attributed to the inconsistent measurements used for H. pylori positivity, IgG antibodies were used to define infection in most studies. IgG antibodies reflect prior infection, but are not sensitive indicators of current infection.…”

Section: Discussioncontrasting

confidence: 93%

Helicobacter pylori infection among patients with type II diabetes mellitus

Al-Arnoot¹,

Al-Awadhi²,

Bahaj³

et al. 2020

JDMDC

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Introduction: H. pylori is the most common human bacterial pathogen that colonizes the gastric epithelium especially in those habitual Qat chewers; it influence can absorption of glucose which is also abnormal in DM patients, its common infection in diabetic patients who have inadequate metabolic control, this study was conducted to reveal the prevalence of H. pylori among T2DM and non-DM patients and potential risk factors. Methods:A cross-sectional study was conducted in some hospitals and clinics in Ibb city, Yemen, and there were 200 patients who included in this study. Data were collected through structural intervals questionnaire and sampling information. Results:The overall prevalence of H. pylori among diabetics and non-diabetics was 39.0%. Its prevalence in diabetics was 49%, while in non-diabetics was 29%.There was strong significant association between H.pylori infections and diabetes P=0.004, H.pylori infections and Qat chewing P=0.003 and H.pylori infection and the increase in HbA1c P=0.001. Conclusion:Positive H. pylori DM patients should update their sugar level values and control the disease. Further research is highly recommended on relationship between H. pylori infections and diabetes complications (using a cohort study) enhancing personal hygiene and prevention of chewing Qat is essential to decrease the risk of infection.

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Section: Discussioncontrasting

confidence: 93%

Helicobacter pylori infection among patients with type II diabetes mellitus

Al-Arnoot¹,

Al-Awadhi²,

Bahaj³

et al. 2020

JDMDC

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“…In fact, our study provides evidence for this possibility by comparing the HbA1c level in eradication success diabetics and failure ones, and better glycemic control was found in diabetes succeed in H. pylori eradication compared with those diabetics failed in treatment (Figure h), which means diabetics with poor glycemic control have a higher risk of failure than better glycemic one. The study of Nam et al 38 also suggested that HbA1c (⩾7.5%) was a significant factor predicting H. pylori eradication in T2DM. Considering the limited number of studies analyzing whether glycemic control affects H. pylori eradication, our results need to be validated by more clinic trials.…”

Section: Discussionmentioning

confidence: 92%

“…The main characteristics of the studies included were shown in Table 1. In all studies included, 11 prospective studies compared the H. pylori eradication rate in diabetes and non‐diabetes 29‐39 . Eleven retrospective studies compared the proportion of diabetes and other clinic factors (age, gender, smoking, drinking, overweight, peptic ulcer disease, blood pressure, and history of NSAIDS) in groups failed and succeed in H. pylori eradication 40‐50 .…”

Section: Resultsmentioning

confidence: 99%

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The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

et al. 2021

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Background and Aims Previous studies have revealed the association between Helicobacter pylori (H. pylori) and diabetes mellitus, but conflicts still exist. The present study tried to investigate the underlying link between these two diseases by making comprehensive analyses of the impact of diabetes on H. pylori eradication and the influence of H. pylori eradication on diabetes. Methods We systematically searched relevant studies from PubMed, Cochrane Library, Web of Science, and Embase updated to April 23, 2020. Studies examining the association between H. pylori eradication and diabetes were included. Pooled odds ratio (OR) and weighted mean differences (WMD) were calculated for different results. Results Among the 2125 retrieved studies, 36 studies were included. Patients with type 2 diabetes mellitus (T2DM) have higher risk of H. pylori eradication failure than the non‐diabetic one (OR = 2.59, 95% CI 1.82–3.70). Body mass index (BMI) was identified as a major factor affecting the efficacy of H. pylori eradication in diabetics, and better glycemic control was also found in eradication succeed patients (WMD: 0.51, 95% CI 0.20–0.81). Moreover, after eradication of H. pylori, improvement of HbA1c was proved (WMD = −0.33, 95% CI −0.65 to −0.02) in T2DM. Conclusion A higher risk of H. pylori eradication failure in T2DM was confirmed, and it was associated with BMI and glycemic control. Moreover, we also provided evidence that H. pylori eradication could improve glycemic control in patients with T2DM, which indirectly reflect the interaction between H. pylori and the diabetes.

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“…The reason could be due to a small number of PM (only four poor metabolisers) involved in this study which made interpretation difficult. The patients from the PM group were smokers 19 and comorbid with diabetes mellitus 20 which might influence on eradication despite poor metaboliser status. As additional finding of our study, alcohol drinkers and betel chewers got higher eradication rate than non-drinkers and non-betel chewer but that were not statistically significant.…”

Section: Characteristicsmentioning

confidence: 99%

High‐dose dual therapy and CYP2C19 polymorphism in Helicobacter pylori eradication

et al. 2021

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Helicobacter pylori infection is common worldwide. There are many treatment regimens regarding H pylori infection over decades.Due to increasing antibiotic resistance, higher treatment failure rate for H pylori is a growing global concern. The significant number of primary drug resistance to amoxicillin, clarithromycin and metronidazole were reported in America, Europe as well as in Asia. 1 The drug resistance was more common in ASEAN region. 1 Antimicrobial susceptibility testing has been suggested in areas of high antibiotic resistance after the failure of first-line treatment. 2,3 However, this test is not available in most centres particularly in resource limited countries. To solve this problem, treatment protocols with substantially high eradication rates and low antibiotic

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Helicobacter pylori eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study

Cited by 13 publications

References 35 publications

Helicobacter pylori infection among patients with type II diabetes mellitus

Helicobacter pylori infection among patients with type II diabetes mellitus

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

High‐dose dual therapy and CYP2C19 polymorphism in Helicobacter pylori eradication

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