<i>Helicobacter pylori</i> in Africa: Observations on an ‘enigma within an enigma’

Kidd, Mark; Louw, J. A.; Marks, I. N.

doi:10.1046/j.1440-1746.1999.01975.x

Cited by 57 publications

(54 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Attracting attention is the high prevalence of H. pylori infection in developing countries which does not commensurate the low prevalence of gastric cancer unlike in developed nations with a generally low prevalence of infection and yet a high prevalence of gastric cancer (Holcombe, 1992). Typically, infection with H. pylori is acquired early in childhood but it is difficult to ascertain when infection occurs clinically hence seroprevalence data are the source of information of H. pylori rates both in geographically and demographically diverse populations (Kidd et al, 1999a;Logan and Walker, 2002). A high prevalence of this organism has also been reported in children in the Western World (Thomas et al, 2004).…”

Section: Prevalence Of Helicobacter Pylorimentioning

confidence: 99%

“…Its association with gastric cancer warranted it's classification as a class-1 carcinogen by the World Health Organization Tanih et al, 2009 of H. pylori which varies geographically and even between ethnic groups, and races in the same region (Wirth et al, 2004). Carriage of H. pylori is usually long term and begins most often in infancy (Kidd et al, 1999a;Segal et al, 2001;Tkachenko et al, 2007). Frequently, the infection starts in the antrum and spreads to the corpus after extensive mucosal damage.…”

Section: Introductionmentioning

confidence: 99%

“…A high prevalence of H. pylori has been reported in Africa presenting as the main cause of at least 90% of duodenal ulcers and 70% of gastric ulcers on the continent Ndip et al, 2004;2008;Tanih et al, 2010a). In various regions of sub-Saharan Africa, the pathogen has been isolated in about 61-90% of per-sons (Holcombe, 1992;Kidd et al, 1999a). Involvement of H. pylori in gastric patients in Cameroon (Ndip et al, 2008) revealed a similar pattern to that recorded among Ghanian patients (Baako et al, 1996) with dyspeptic symptoms and in South African patients with non-ulcer dyspepsia .…”

Section: Introductionmentioning

confidence: 99%

“…For example, in Africa, the prevalence of infection is very high but the incidence of gastric carcinoma and other H. pyloriassociated morbidities is relatively low. This apparent anomality has been termed the 'African enigma' (Holcombe, 1992;Kidd et al, 1999a;Ahmed et al, 2007). H. pylori infection is common in South Africa, as might be expected in developing countries (Pelser et al, 1997;Mosane et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…H. pylori infection is common in South Africa, as might be expected in developing countries (Pelser et al, 1997;Mosane et al, 2004). Reports on prevalence of the organism in the country are mostly derived from seroprevalence data (Kidd et al, 1999a;O'keefe et al, 2000), which does not provide more information other than the presence of antibodies, which are poor mar-kers of active infection. However, some investigators have used alternative phenotypic (such as culture) or molecular based methods to report on the prevalence of the organism in their study area in the country (Kidd et al, 1999b;Louw et al, 2001;Kidd et al, 2001;Tanih et al, 2010a;2010b).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A South African perspective on Helicobacter pylori: Prevalence, epidemiology and antimicrobial chemotherapy

Nicoline¹,

Rol²,

Ndip³

2013

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

The spiral shaped Gram-negative bacterium, Helicobacter pylori colonizes the stomach of more than 50% of the world's population and can persist for a lifetime if not completely eradicated. High prevalence of the bacterium is common in most population although a majority of the infected patients remain asymptomatic; with only a small subset of infected people experiencing H. pylori-associated illnesses such as chronic gastritis, gastric and duodenal ulcers, mucosa associated lymphoid tissue lymphoma as well as adenocarcinoma. H. pylori is common in South Africa with prevalence ranging from 50 -84% as depicted in the various studies conducted across the country. Infection is usually acquired in childhood and is associated with low socio-economic status, overcrowding, poor sanitation and unclean water supplies which appear to influence the rate of transmission. Eradication of this pathogen is a global challenge due to its alarming rate of drug resistance. Triple therapy consisting of a proton pump inhibitor and clarithromycin and either metronidazole or amoxicillin, is recommended for treatment. In this article, we review the major studies conducted based on H. pylori prevalence, epidemiology and antimicrobial chemotherapy in South Africa. Overall, the results of the findings indicate a high prevalence of H. pylori, resistance to recommended therapy and identified the need to consider natural products, including medicinal plants and honey as leads, which may offer useful alternatives in the treatment of H. pylori-related infections in South Africa and the world at large.

show abstract

Section: Prevalence Of Helicobacter Pylorimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A South African perspective on Helicobacter pylori: Prevalence, epidemiology and antimicrobial chemotherapy

Nicoline¹,

Rol²,

Ndip³

2013

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

show abstract

Peptic Ulcer Disease

Ingram

Ragunath

Atherton

2015

Yamada' S Textbook of Gastroenterology

View full text Add to dashboard Cite

Histomolecular profile of Helicobacter pylori strains circulating in Brazzaville (Congo)

Atipo‐Ibara,

Boumba,

Ibara Ollandzobo Ikobo

et al. 2024

JGH Open

View full text Add to dashboard Cite

Background and AimHelicobacter pylori (Hp) infection is a real public health problem in the Congo. We aimed study the histomolecular profile of Hp strains circulating in Brazzaville, Congo, in order to contribute to the improvement of Hp‐infected patients in the country.MethodsThis was an analytical‐transversal study carried out from January to November 2020 (i.e. a study period of 11 months) in the endoscopy centers of Brazzaville as well as the molecular biology and anatomopathology laboratories of Pointe‐Noire and Oyo. It involved 100 symptomatic patients over the age of 18 referred for upper GI endoscopy. These patients underwent gastric biopsies for histopathological analysis according to the Sydney classification and molecular analysis using the real‐time polymerase chain reaction (PCR) technique. The frequency of Hp infection was determined using real‐time PCR. PCR was also used to identify the Hp strains and assess their tropism in the gastric mucosa. Digestive symptoms, endoscopic lesions, and histopathological lesions associated with HP infection were studied.ResultsThe incidence of Hp infection was 91%, with a female predominance of 52.75% and an average age of 46.32 years. Endoscopy revealed normal mucosa (56.14%), ulcerated lesions (12.28%), and gastritis (22.81%) in infected patients. Histopathologically, the lesions were chronic atrophic gastritis (91%), with inflammatory activity (16.46%), intestinal metaplasia (16.46%), and adenocarcinoma (3.3%). Cag A strains were present in 85.71% of cases and had no preferential tropism in the gastric mucosa. Strains carrying the Cag A gene were present in severe and serious endoscopic and histopathological lesions.ConclusionThe prevalence of Hp infection is 91% in the Brazzaville population. Cag A strains circulate in high proportions and are implicated in the occurrence of severe lesions of the gastric mucosa.

show abstract

Helicobacter pylori in Africa: Observations on an ‘enigma within an enigma’

Abstract: It would appear that prospective endoscopic-based studies in African subjects may question the standard dogma of a low prevalence of H. pylori-associated diseases in Africa. Further research is clearly required.

Cited by 57 publications

References 27 publications

A South African perspective on Helicobacter pylori: Prevalence, epidemiology and antimicrobial chemotherapy

A South African perspective on Helicobacter pylori: Prevalence, epidemiology and antimicrobial chemotherapy

Peptic Ulcer Disease

Histomolecular profile of Helicobacter pylori strains circulating in Brazzaville (Congo)

Contact Info

Product

Resources

About